GB1084439A - Improvements in or relating to heteroeyclic compounds and the manufacture thereof - Google Patents

Improvements in or relating to heteroeyclic compounds and the manufacture thereof

Info

Publication number
GB1084439A
GB1084439A GB5160664A GB5160664A GB1084439A GB 1084439 A GB1084439 A GB 1084439A GB 5160664 A GB5160664 A GB 5160664A GB 5160664 A GB5160664 A GB 5160664A GB 1084439 A GB1084439 A GB 1084439A
Authority
GB
United Kingdom
Prior art keywords
phenyl
alkyl
mono
prepared
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5160664A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1084439A publication Critical patent/GB1084439A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91Dibenzofurans; Hydrogenated dibenzofurans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel compounds of the general formula <FORM:1084439/C2/1> (wherein n is 1, 2, or 3, and R1 and R2 each represent a C1- 8 alkyl, C7- 12 aralkyl, phenyl, mono- or di-(C1- 8 alkyl or alkoxy) phenyl or mono- or di-halophenyl radical, but are not both phenyl or substituted phenyl, or R1 and R2 jointly represent an alkylene, oxoalkylene, thioalkylene or N-(C1- 8 alkyl)-azoalkylene radical forming with N a 5-7 membered heterocyclic ring) are prepared by condensing p-benzoquinone with a cycloalkenamine of the formula <FORM:1084439/C2/2> The products may be esterified with C1- 6 alkanoic acids (or derivatives thereof), and both the free phenols and the esters may be converted to acid addition salts, or to N-oxides by treatment with a peroxidizing agent. Cycloalkenamines of the second general formula above are prepared by reacting cyclopentanone, cyclohexanone or cycloheptanone with a secondary amine R1.NH.R2.
GB5160664A 1963-12-31 1964-12-18 Improvements in or relating to heteroeyclic compounds and the manufacture thereof Expired GB1084439A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33493463A 1963-12-31 1963-12-31

Publications (1)

Publication Number Publication Date
GB1084439A true GB1084439A (en) 1967-09-20

Family

ID=23309512

Family Applications (2)

Application Number Title Priority Date Filing Date
GB5160664A Expired GB1084439A (en) 1963-12-31 1964-12-18 Improvements in or relating to heteroeyclic compounds and the manufacture thereof
GB1650067A Expired GB1084440A (en) 1963-12-31 1964-12-18 Improvements in or relating to (2-aminocycloalkyl) hydroquinones and the manufacturethereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1650067A Expired GB1084440A (en) 1963-12-31 1964-12-18 Improvements in or relating to (2-aminocycloalkyl) hydroquinones and the manufacturethereof

Country Status (4)

Country Link
CH (1) CH462803A (en)
FR (1) FR1458097A (en)
GB (2) GB1084439A (en)
NL (1) NL6415270A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613365A1 (en) * 1987-04-01 1988-10-07 Adir NOVEL DERIVATIVES OF AMINO TETRAHYDRO-5, 6, 7, 8 NAPHTO (2, 3B) FURANNE, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2613364A1 (en) * 1987-04-01 1988-10-07 Adir NOVEL TRICYCLIC AMINES DERIVED FROM TETRAHYDRO-5, 6, 7, 8 NAPHTO (2,3B) DIHYDRO-2,3-FURANNE, AND TETRAHYDRO-6,7,8,9-5H-BENZOCYCLOHEPTA (2,3B) DIHYDRO-2, 3 FURANNE, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668690A (en) * 1985-12-30 1987-05-26 Hoechst Roussel Pharmaceuticals Inc. 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans useful as analgesics, anticonvulsants or antidepressants

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613365A1 (en) * 1987-04-01 1988-10-07 Adir NOVEL DERIVATIVES OF AMINO TETRAHYDRO-5, 6, 7, 8 NAPHTO (2, 3B) FURANNE, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2613364A1 (en) * 1987-04-01 1988-10-07 Adir NOVEL TRICYCLIC AMINES DERIVED FROM TETRAHYDRO-5, 6, 7, 8 NAPHTO (2,3B) DIHYDRO-2,3-FURANNE, AND TETRAHYDRO-6,7,8,9-5H-BENZOCYCLOHEPTA (2,3B) DIHYDRO-2, 3 FURANNE, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
EP0286515A1 (en) * 1987-04-01 1988-10-12 Adir Et Compagnie 5,6,7,8-Tetrahydro-naphtho [2,3b]-2,3-dihydrofuran and 6,7,8,9-tetrahydro-5H-benzocyclohepta [2,3b]-2,3-dihydro furan tricyclic amine derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0286516A1 (en) * 1987-04-01 1988-10-12 Adir Et Compagnie Amino-5,6,7,8-tetrahydro-naphtho[2,3b]furan derivatives, processes for their preparation and pharmaceutical compositions containing them
GR880100208A (en) * 1987-04-01 1989-01-31 Adir Preparation method of new aminotetrahydro-5,6,7,8,naphtho (2,3b) furane
GR880100207A (en) * 1987-04-01 1989-01-31 Adir Preparation of new tricyclic amino derivatives of tetrahydro-5,6,7 naphtho-2,3

Also Published As

Publication number Publication date
CH462803A (en) 1968-09-30
GB1084440A (en) 1967-09-20
NL6415270A (en) 1965-07-02
FR1458097A (en) 1966-11-10

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