GB883599A - 3-(3-amino-1-alkenyl)-indoles - Google Patents
3-(3-amino-1-alkenyl)-indolesInfo
- Publication number
- GB883599A GB883599A GB19575/59A GB1957559A GB883599A GB 883599 A GB883599 A GB 883599A GB 19575/59 A GB19575/59 A GB 19575/59A GB 1957559 A GB1957559 A GB 1957559A GB 883599 A GB883599 A GB 883599A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkyl group
- group
- amino
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0883599/IV (b)/1> wherein R1 represents hydrogen or a C1-6 alkyl group, R2 represents hydrogen, a C1-6 alkyl or a C7-13 aralkyl, a C6-10 aryl group or a haloaryl group R3 and R4 each represent hydrogen or a C1-6 alkyl group, R5 and R6 each represent a C1-6 alkyl group, a C7-13 aralkyl group or a C6-10 aryl group or R5 and R6 taken together with the adjacent nitrogen atom represent a heterocyclic radical containing 5-7 ring atoms one of which, in addition to the amino-N atom may be nitrogen, oxygen or sulphur, the other ring atoms being carbon, and the 4, 5, 6 and 7-positions in the benzene ring may be substituted by a cyano, carbalkoxy (wherein the alkyl group contains 1-8 carbon atoms), di-(C1-8 alkyl) amino, C7-13-aralkoxy, C1-6 alkoxy, C1-6 alkyl, C1-13 aralkyl, C6-10 aryl; the acid addition salts and the corresponding N-oxides and N-oxide acid addition salts; and the preparation thereof by reacting a compound of the general formula <FORM:0883599/IV (b)/2> with a chloroformate Cl-COOR, wherein R is a C1-6 alkyl group in the presence of a tertiary amine. The N-oxides are prepared by reacting the base with an oxidising agent. The 3-(3-amino-1-hydroxypropyl) indoles are prepared by reducing the corresponding ketone in turn prepared by reacting a 3-acylindole with an appropriate amine and aldehyde. Specifications 809,795, 834,028 and U.S.A. Speci-fications 1,915,334 and 2,075,359 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US883599XA | 1958-06-11 | 1958-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB883599A true GB883599A (en) | 1961-12-06 |
Family
ID=22210920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB19575/59A Expired GB883599A (en) | 1958-06-11 | 1959-06-08 | 3-(3-amino-1-alkenyl)-indoles |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB883599A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4336391A (en) * | 1981-04-06 | 1982-06-22 | Sandoz, Inc. | Isoxazolyl indolamines |
-
1959
- 1959-06-08 GB GB19575/59A patent/GB883599A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4336391A (en) * | 1981-04-06 | 1982-06-22 | Sandoz, Inc. | Isoxazolyl indolamines |
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