GB883599A - 3-(3-amino-1-alkenyl)-indoles - Google Patents

Abstract

The invention comprises compounds of the general formula <FORM:0883599/IV (b)/1> wherein R1 represents hydrogen or a C1-6 alkyl group, R2 represents hydrogen, a C1-6 alkyl or a C7-13 aralkyl, a C6-10 aryl group or a haloaryl group R3 and R4 each represent hydrogen or a C1-6 alkyl group, R5 and R6 each represent a C1-6 alkyl group, a C7-13 aralkyl group or a C6-10 aryl group or R5 and R6 taken together with the adjacent nitrogen atom represent a heterocyclic radical containing 5-7 ring atoms one of which, in addition to the amino-N atom may be nitrogen, oxygen or sulphur, the other ring atoms being carbon, and the 4, 5, 6 and 7-positions in the benzene ring may be substituted by a cyano, carbalkoxy (wherein the alkyl group contains 1-8 carbon atoms), di-(C1-8 alkyl) amino, C7-13-aralkoxy, C1-6 alkoxy, C1-6 alkyl, C1-13 aralkyl, C6-10 aryl; the acid addition salts and the corresponding N-oxides and N-oxide acid addition salts; and the preparation thereof by reacting a compound of the general formula <FORM:0883599/IV (b)/2> with a chloroformate Cl-COOR, wherein R is a C1-6 alkyl group in the presence of a tertiary amine. The N-oxides are prepared by reacting the base with an oxidising agent. The 3-(3-amino-1-hydroxypropyl) indoles are prepared by reducing the corresponding ketone in turn prepared by reacting a 3-acylindole with an appropriate amine and aldehyde. Specifications 809,795, 834,028 and U.S.A. Speci-fications 1,915,334 and 2,075,359 are referred to.