GB689877A - The thiosemicarbazone of nicotinic aldehyde and process for its preparation - Google Patents

The thiosemicarbazone of nicotinic aldehyde and process for its preparation

Info

Publication number
GB689877A
GB689877A GB17166/51A GB1716651A GB689877A GB 689877 A GB689877 A GB 689877A GB 17166/51 A GB17166/51 A GB 17166/51A GB 1716651 A GB1716651 A GB 1716651A GB 689877 A GB689877 A GB 689877A
Authority
GB
United Kingdom
Prior art keywords
aldehyde
nicotinic
thiosemicarbazide
heated
nicotinic aldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17166/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Francais de Chimiotherapie SA filed Critical Laboratoires Francais de Chimiotherapie SA
Publication of GB689877A publication Critical patent/GB689877A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention comprises the thiosemicarbazone of nicotinic aldehyde, and the preparation thereof by condensing nicotinic aldehyde with thiosemicarbazide in an aqueous alcoholic or acetic acid medium. The product is useful for the treatment of tuberculosis. In examples: (1) nicotinic aldehyde and thiosemicarbazide are heated in aqueous ethanol; (2) the symmetrical hydrazide of nicotinic acid and benzene sulphonic acid is heated with sodium carbonate in ethylene glycol, the resulting reaction mixture containing nicotinic aldehyde is acidified with aqueous acetic acid through which the evolved nitrogen has been bubbled to trap any aldehyde carried over thereby, and the acidified solution is heated with thiosemicarbazide.
GB17166/51A 1950-08-17 1951-07-19 The thiosemicarbazone of nicotinic aldehyde and process for its preparation Expired GB689877A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR689877X 1950-08-17

Publications (1)

Publication Number Publication Date
GB689877A true GB689877A (en) 1953-04-08

Family

ID=9027518

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17166/51A Expired GB689877A (en) 1950-08-17 1951-07-19 The thiosemicarbazone of nicotinic aldehyde and process for its preparation

Country Status (1)

Country Link
GB (1) GB689877A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2744905A (en) * 1953-08-17 1956-05-08 Schenley Ind Inc Process for the production of thiosemicarbazones of isonicotinaldehyde and 4-pyridyl alkyl ketones
US2744906A (en) * 1953-10-30 1956-05-08 Schenley Ind Inc Process for the production of the thiosemicarbazone isonicotinaldehyde
DE1008294B (en) * 1953-10-30 1957-05-16 Bayer Ag Process for the preparation of pyridine aldehyde thiosemicarbazones

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2744905A (en) * 1953-08-17 1956-05-08 Schenley Ind Inc Process for the production of thiosemicarbazones of isonicotinaldehyde and 4-pyridyl alkyl ketones
US2744906A (en) * 1953-10-30 1956-05-08 Schenley Ind Inc Process for the production of the thiosemicarbazone isonicotinaldehyde
DE1008294B (en) * 1953-10-30 1957-05-16 Bayer Ag Process for the preparation of pyridine aldehyde thiosemicarbazones

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