Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16632/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Societe des Usines Chimiques Rhone Poulenc SA
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Filing date
Publication date
Application filed by Rhone Poulenc SA, Societe des Usines Chimiques Rhone Poulenc SAfiledCriticalRhone Poulenc SA
Publication of GB724863ApublicationCriticalpatent/GB724863A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The invention comprises streptomycin isonicotinylhydrazone and its salts, and the production thereof from isonicotinyl hydrazide and a salt of streptomycin, the former being used in excess. The reaction may take place in aqueous medium either above or below 50 DEG C., e.g. at 0-10 DEG C. or at reflux temperature, the product being precipitated by the addition of a solvent (e.g. methanol) in which it is sparingly soluble, preferably after concentration of the aqueous medium. Alternatively the aqueous solution is azeotropically dehydrated (e.g. with benzene), with or without initial concentration. The reaction may also take place in an organic medium which is a solvent for the streptomycin salt, e.g. ethylene glycol at 0-100 DEG C. Examples are given of various ways of preparing the sulphate of streptomycin isonicotinylhydrazone from streptomycin sulphate and isonicotinyl hydrazide.
GB16632/53A1952-06-171953-06-16Improvements in or relating to therapeutic agents
ExpiredGB724863A
(en)
PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS CONTAINING AN ACID ADDITIONAL SALT OF A SUBSTITUTED PYRIDYL GROUP CONTAINING N-SUBSTITUATED DERIVATIVE OF THE N '- (3-P-FLUORBENZOYLPROEPORMINE, USED BEFORE INSERTING MEDIPROPROPYL, USED BEFORE INSERTING MEDIPROPROPYL) PREPARATION OF SUCH COMPOUNDS.
Procedure for the preparation of n (dietilaminoetil) - 2 - metoxy - 4 - amino 5 - chloro - benzamide. (Machine-translation by Google Translate, not legally binding)