GB636347A - Improvements in and relating to the manufacture of aromatic amino carboxylic acids - Google Patents

Improvements in and relating to the manufacture of aromatic amino carboxylic acids

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Publication number
GB636347A
GB636347A GB1520547A GB1520547A GB636347A GB 636347 A GB636347 A GB 636347A GB 1520547 A GB1520547 A GB 1520547A GB 1520547 A GB1520547 A GB 1520547A GB 636347 A GB636347 A GB 636347A
Authority
GB
United Kingdom
Prior art keywords
acid
alkali metal
bicarbonate
amino
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1520547A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DAVID DUNCANSON MARTIN
Smith and Nephew Nominee Services Ltd
Original Assignee
DAVID DUNCANSON MARTIN
Herts Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DAVID DUNCANSON MARTIN, Herts Pharmaceuticals Ltd filed Critical DAVID DUNCANSON MARTIN
Priority to GB1520547A priority Critical patent/GB636347A/en
Publication of GB636347A publication Critical patent/GB636347A/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Alkali metal salts of 2-hydroxy-4-amino-benzoic acid are prepared by heating m-aminophenol with carbon dioxide and alkali metal hydroxide, carbonate or bicarbonate at 105-135 DEG C. in a polyhydric alcohol. The free acid may be isolated by adding hydrochloric acid to the reaction product until just acid to litmus or by adding the reaction product to an excess of hydrochloric acid to precipitate the hydrochloride of the amino acid which is separated, dried and decomposed by the addition of an alkali metal bicarbonate and just sufficient water to dissolve the alkali metal chloride formed. In an example, m-amino-phenol is heated with potassium bicarbonate in glycerol at 130 DEG C. while a stream of carbon dioxide is passed in, the product is converted to the hydrochloride from which the free acid is liberated by the addition of the equivalent quantity of sodium bicarbonate.
GB1520547A 1947-06-10 1947-06-10 Improvements in and relating to the manufacture of aromatic amino carboxylic acids Expired GB636347A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1520547A GB636347A (en) 1947-06-10 1947-06-10 Improvements in and relating to the manufacture of aromatic amino carboxylic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1520547A GB636347A (en) 1947-06-10 1947-06-10 Improvements in and relating to the manufacture of aromatic amino carboxylic acids

Publications (1)

Publication Number Publication Date
GB636347A true GB636347A (en) 1950-04-26

Family

ID=10054882

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1520547A Expired GB636347A (en) 1947-06-10 1947-06-10 Improvements in and relating to the manufacture of aromatic amino carboxylic acids

Country Status (1)

Country Link
GB (1) GB636347A (en)

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