GB668674A - 4-amino-2-hydroxybenzene-1.5-dicarboxylic acid and a process for the production thereof - Google Patents

4-amino-2-hydroxybenzene-1.5-dicarboxylic acid and a process for the production thereof

Info

Publication number
GB668674A
GB668674A GB3646/50A GB364650A GB668674A GB 668674 A GB668674 A GB 668674A GB 3646/50 A GB3646/50 A GB 3646/50A GB 364650 A GB364650 A GB 364650A GB 668674 A GB668674 A GB 668674A
Authority
GB
United Kingdom
Prior art keywords
amino
salt
hydroxybenzene
dicarboxylic acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3646/50A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cilag AG
Original Assignee
Cilag AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cilag AG filed Critical Cilag AG
Publication of GB668674A publication Critical patent/GB668674A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/02—Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises 4-amino-2-hydroxybenzene-1,5-dicarboxylic acid, and a method of preparation by treating with heat, carbon dioxide and a carbonate a compound of the general formula <FORM:0668674/IV (b)/1> in which the hydrogen atom in the p-position to the hydroxy or amino group has been replaced by the carboxyl group, or a salt of the same compound. The reaction may be carried out in an aqueous medium and/or under pressure. Suitable carbonates are alkali or alkaline earth bicarbonates, e.g. potassium bicarbonate. The above compound may also be prepared by introducing formyl groups into the above starting materials and oxidizing the formyl groups to carboxyl groups. The 4 - amino - 2 - hydroxybenzene 1,5 - dicarboxylic acid can be isolated in the form of its salt, e.g. the sodium or calcium salt or a salt with an organic base.
GB3646/50A 1949-03-24 1950-02-13 4-amino-2-hydroxybenzene-1.5-dicarboxylic acid and a process for the production thereof Expired GB668674A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH668674X 1949-03-24

Publications (1)

Publication Number Publication Date
GB668674A true GB668674A (en) 1952-03-19

Family

ID=4527490

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3646/50A Expired GB668674A (en) 1949-03-24 1950-02-13 4-amino-2-hydroxybenzene-1.5-dicarboxylic acid and a process for the production thereof

Country Status (1)

Country Link
GB (1) GB668674A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104370766A (en) * 2013-08-14 2015-02-25 重庆华邦制药有限公司 Industrial production method of m-phthalic acid derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104370766A (en) * 2013-08-14 2015-02-25 重庆华邦制药有限公司 Industrial production method of m-phthalic acid derivatives
CN104370766B (en) * 2013-08-14 2018-03-27 重庆华邦制药有限公司 The method of industrialized production isophthalic acid derivatives

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