GB636333A - Improvements in and relating to the manufacture of aromatic amino carboxylic acids - Google Patents
Improvements in and relating to the manufacture of aromatic amino carboxylic acidsInfo
- Publication number
- GB636333A GB636333A GB523247A GB523247A GB636333A GB 636333 A GB636333 A GB 636333A GB 523247 A GB523247 A GB 523247A GB 523247 A GB523247 A GB 523247A GB 636333 A GB636333 A GB 636333A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon dioxide
- alkali metal
- bicarbonate
- acid
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Alkali metal salts of 4-amino-2-hydroxy benzoic acid are prepared by the reaction of carbon dioxide with m-aminophenol in the presence of an alkali metal hydroxide, carbonate or p bicarbonate and water, preferably at a temperature of over 100 DEG C. Conveniently, the reaction may be carried out by heating m-amino phenol with the alkali-metal compound and solid carbon dioxide in an autoclave at about 130 DEG C. The free acid may be liberated from the reaction product by adding dilute hydrochloric acid until just acid to litmus, or by dissolving in an excess of hydrochloric acid to form the aminoacid hydrochloride which is separated and dried and treated with an equivalent quantity of an alkali metal bicarbonate and just sufficient water to dissolve the alkali metal chloride formed. In examples: (1) m-aminophenol, potassium bicarbonate, solid carbon dioxide and water are heated in an autoclave and the reaction product is neutralized with hydrochloric acid to give 4-amino-2-hydroxy benzoic acid; (2) sodium bicarbonate is used in place of potassium bicarbonate in (1) and (3), the process (1) is repeated using gaseous carbon dioxide in place of solid carbon dioxide and the product is separated by means of the aminoacid hydrochloride. Reference has been directed by the Comptroller to Berichte der Deutschen Chemischen Gesellschaft (Referat), Volume 23 (1890), page 313.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB523247A GB636333A (en) | 1947-02-22 | 1947-02-22 | Improvements in and relating to the manufacture of aromatic amino carboxylic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB523247A GB636333A (en) | 1947-02-22 | 1947-02-22 | Improvements in and relating to the manufacture of aromatic amino carboxylic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB636333A true GB636333A (en) | 1950-04-26 |
Family
ID=9792193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB523247A Expired GB636333A (en) | 1947-02-22 | 1947-02-22 | Improvements in and relating to the manufacture of aromatic amino carboxylic acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB636333A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2700669A (en) * | 1951-09-27 | 1955-01-25 | American Cyanamid Co | Hydroxybenzotriazole carboxylic acids |
| DK85717C (en) * | 1950-06-24 | 1958-06-16 | Smith & Nephew | Process for the preparation of p-amino-salicylic acid or salts thereof. |
-
1947
- 1947-02-22 GB GB523247A patent/GB636333A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK85717C (en) * | 1950-06-24 | 1958-06-16 | Smith & Nephew | Process for the preparation of p-amino-salicylic acid or salts thereof. |
| US2700669A (en) * | 1951-09-27 | 1955-01-25 | American Cyanamid Co | Hydroxybenzotriazole carboxylic acids |
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