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Expired
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GB16631/56A
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Instituto de Angeli SpA
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Instituto de Angeli SpA
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Publication of GB789788ApublicationCriticalpatent/GB789788A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
N - n - Butyl - N1 - (p - acetamidobenzene sulphonyl)-urea is prepared by reacting n-butylcarbamyl chloride with an anhydrous inorganic or organic salt of N4-acetylsulphanilamide. The preferred salts are those of alkali metals and of tertiary organic bases, e.g. pyridine, and in the latter case the salt is preferably formed in situ. In examples: (1) N4-acetylsulphanilamide in anhydrous pyridine is treated with n-butylcarbamyl chloride and the mixture heated to 120-25 DEG C., yielding N-n-butyl-N1-(p - acetamidobenzenesulphonyl) - urea, purified by solution in aqueous sodium carbonate, reprecipitation with acid, and crystallization from aqueous alcohol; (2) the sodium salt of N4-acetylsulphanilamide is treated with n-butylcarbamyl chloride yielding N-n-butyl-N1-(p-acetamidobenzenesulphonyl)-urea which is purified as in (1). Subsequent saponification with boiling 10 per cent NaOH yields N-n-butyl-N1-sulphanilyl-urea.
GB16631/56A1956-04-141956-05-29A method for the preparation of n-ú¯-butyl-n-(ú-acetamido-benzene-sulfonyl)-urea
ExpiredGB789788A
(en)