FR2336403A1 - Theophyllin-substd. propanesulphonic acid prepn. - by reaction of theophyllin with a disubstituted propane - Google Patents

Theophyllin-substd. propanesulphonic acid prepn. - by reaction of theophyllin with a disubstituted propane

Info

Publication number
FR2336403A1
FR2336403A1 FR7539682A FR7539682A FR2336403A1 FR 2336403 A1 FR2336403 A1 FR 2336403A1 FR 7539682 A FR7539682 A FR 7539682A FR 7539682 A FR7539682 A FR 7539682A FR 2336403 A1 FR2336403 A1 FR 2336403A1
Authority
FR
France
Prior art keywords
theophyllin
reaction
acid
alkali metal
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7539682A
Other languages
French (fr)
Other versions
FR2336403B1 (en
Inventor
Jacques De Antoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bruneau et Cie Laboratoires
Original Assignee
Bruneau et Cie Laboratoires
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bruneau et Cie Laboratoires filed Critical Bruneau et Cie Laboratoires
Priority to FR7539682A priority Critical patent/FR2336403A1/en
Publication of FR2336403A1 publication Critical patent/FR2336403A1/en
Application granted granted Critical
Publication of FR2336403B1 publication Critical patent/FR2336403B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Prepn. of 3-(7-theophyllinyl)propanesulphonic acid (I) is by reaction of theophyllin in presence of an alkali metal hydroxide with a substd. propane of formula X CH2-CH2-CH2-Y (II) (where X is Cl, Br, I or sulphonyloxy residues of sulphonic acids; Y is as X or alkali metal sulphonate). Product (III) is reacted with an alkali metal sulphonate (when Y is not alkali metal sulphonate). (III) is then treated with an acid to give the free sulphonic acid. (I) is a cerebral and coronary vasolidator and spasmolytic. Typically 3-(7-theophyllinyl)propanesulphonic acid was prepd. by reaction of theophyllin with sodium chloropropanesulphonate at 80 degrees C, cooling to room temp., and acidifying with HCl to give crystals of the required acid.
FR7539682A 1975-12-24 1975-12-24 Theophyllin-substd. propanesulphonic acid prepn. - by reaction of theophyllin with a disubstituted propane Granted FR2336403A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7539682A FR2336403A1 (en) 1975-12-24 1975-12-24 Theophyllin-substd. propanesulphonic acid prepn. - by reaction of theophyllin with a disubstituted propane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7539682A FR2336403A1 (en) 1975-12-24 1975-12-24 Theophyllin-substd. propanesulphonic acid prepn. - by reaction of theophyllin with a disubstituted propane

Publications (2)

Publication Number Publication Date
FR2336403A1 true FR2336403A1 (en) 1977-07-22
FR2336403B1 FR2336403B1 (en) 1978-06-23

Family

ID=9164146

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7539682A Granted FR2336403A1 (en) 1975-12-24 1975-12-24 Theophyllin-substd. propanesulphonic acid prepn. - by reaction of theophyllin with a disubstituted propane

Country Status (1)

Country Link
FR (1) FR2336403A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023032A1 (en) * 1979-07-21 1981-01-28 Hoechst Aktiengesellschaft Process for the preparation of oxoalkylxanthines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023032A1 (en) * 1979-07-21 1981-01-28 Hoechst Aktiengesellschaft Process for the preparation of oxoalkylxanthines

Also Published As

Publication number Publication date
FR2336403B1 (en) 1978-06-23

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Legal Events

Date Code Title Description
AM Act modifying the rights related to an application or a patent
GC Lien (pledge) constituted
ST Notification of lapse