GB867064A - New derivatives of heparin and processes for their production - Google Patents
New derivatives of heparin and processes for their productionInfo
- Publication number
- GB867064A GB867064A GB29457/59A GB2945759A GB867064A GB 867064 A GB867064 A GB 867064A GB 29457/59 A GB29457/59 A GB 29457/59A GB 2945759 A GB2945759 A GB 2945759A GB 867064 A GB867064 A GB 867064A
- Authority
- GB
- United Kingdom
- Prior art keywords
- heparyl
- urea
- heparin
- alkyl
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Abstract
The Specification comprises heparyl substituted ureas having the general formula:- <FORM:0867064/IV (a)/1> in which R represents a heparyl residue and R1 is an alkyl, aryl, or aralkyl group and X is an integer from 1 to 4. These compounds may be made from heparamine (N-desulpho heparin) which is itself made from heparin by the method described in Specification 863,235, by reacting it with an iso-cyanate of general formula R1-N= C=O where R1 is an alkyl, aryl or aralkyl group. Specifie products are N-heparyl-N1-n-butyl-urea; N-heparyl-N1-phenyl-urea; N-heparyl-N1-a -naphthyl urea and their alkali metal salts. Reaction may be effected in an aqueous medium, optionally in the presence of an ammonium or alkali metal hydroxide or carbonate, or in a solvent such as iso-propanol. The substituted urea may be isolated by precipitation with a water miscible solvent in which it is insoluble, such as methanol, ethanol, acetone or dioxan. Alternatively it can be purified by transformation into a quaternary ammonium salt by means of Hyamine 1622, Hyamine 2389, Cequartyl BE, Zephyrol, or an alkyl-dilauryl-dimethyl-ammonium chloride, and recovered by means of an alkali metal salt of a lower fatty acid in aqueous solution such as sodium acetate.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR867064X | 1959-05-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB867064A true GB867064A (en) | 1961-05-03 |
Family
ID=9345403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB29457/59A Expired GB867064A (en) | 1959-05-16 | 1959-08-28 | New derivatives of heparin and processes for their production |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB867064A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4281108A (en) * | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
US4826827A (en) * | 1979-10-05 | 1989-05-02 | Choay S.A. | Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs |
-
1959
- 1959-08-28 GB GB29457/59A patent/GB867064A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826827A (en) * | 1979-10-05 | 1989-05-02 | Choay S.A. | Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs |
US4281108A (en) * | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
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