GB668994A - Process for the purification of adrenalin - Google Patents

Process for the purification of adrenalin

Info

Publication number
GB668994A
GB668994A GB11783/50A GB1178350A GB668994A GB 668994 A GB668994 A GB 668994A GB 11783/50 A GB11783/50 A GB 11783/50A GB 1178350 A GB1178350 A GB 1178350A GB 668994 A GB668994 A GB 668994A
Authority
GB
United Kingdom
Prior art keywords
acid
salts
arterenol
ethoxymethylene
adrenaline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11783/50A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB668994A publication Critical patent/GB668994A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Natural adrenaline is freed from arterenol by contacting an aqueous solution of their acid addition salts with an active methylene compound which may be a lower aliphatic ester of ethoxymethylene - malonic acid, ethoxymethylene-acetoacetic acid, ethoxymethylenecyanoacetic acid, or oxalacetic acid, or acetonylacetone. The reaction is preferably carried out at 75-85 DEG C. in the presence of a water-miscible lower aliphatic alcohol, the active methylene compound being used in 45-50 per cent excess of that required to react with the arterenol present. The mixture is then made alkaline (to pH not above 9.5) when free adrenaline is precipitated. The purification process may be repeated if necessary. The salts of the bases used at the beginning of the process are preferably derived from a weak acid such as acetic, but mineral acid salts may be used. Examples show the use of various methylene compounds, ethyl ethoxymethylenemalonate being preferred. If the product is coloured, it may be treated in acetic acid solution with sodium bisulphite and carbon.
GB11783/50A 1949-07-25 1950-05-11 Process for the purification of adrenalin Expired GB668994A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US668994XA 1949-07-25 1949-07-25

Publications (1)

Publication Number Publication Date
GB668994A true GB668994A (en) 1952-03-26

Family

ID=22072428

Family Applications (1)

Application Number Title Priority Date Filing Date
GB11783/50A Expired GB668994A (en) 1949-07-25 1950-05-11 Process for the purification of adrenalin

Country Status (1)

Country Link
GB (1) GB668994A (en)

Similar Documents

Publication Publication Date Title
GB667870A (en) Process for the preparation of hydroxylamine
GB668994A (en) Process for the purification of adrenalin
GB761093A (en) Production of s-acetyl glutathione
GB934292A (en) Process for the preparation of heterocyclic compounds
GB562267A (en) Process for the manufacture of a crystallised, non-hygroscopic calcium salt of d-pantothenic acid
GB730923A (en) Process for the preparation of a new aldehyde derivative
ES218110A1 (en) Improved bis(beta-hydroxyethyl) terephthalate
GB571157A (en) Manufacture of salts of nitro sulphonic acids
NL32365C (en)
GB633459A (en) A process for the manufacture of n-(p-arsenosobenzyl)-glycine-amide and salts thereof
GB624987A (en) Improvements in and relating to the manufacture of alginate threads
GB728682A (en) Dichloracetoxy-amino-propanol salts and process for the manufacture thereof
GB629439A (en) A process for the manufacture of 2:3:4-triaminopyridine
GB566006A (en) Improvements in or relating to the production of alpha-chloro, beta-hydroxynitriles
GB580509A (en) Process for the manufacture of pantothenic acid and its salts
GB711424A (en) Treatment of delta-tetrahydrobenzaldehyde
GB668567A (en) Improvements in or relating to a method of preparing a stable theophylline composition and the product resulting therefrom
GB695769A (en) Process for the manufacture of d-threo-1-p-nitrophenyl-2-dichloroacetylamino-1,3-propandiol
GB573702A (en) Preparation of alkali metal hydracrylates
GB551305A (en) Improvements in and relating to the preparation of hydroxy dithionaphthoic acids and their derivatives
GB615602A (en) Improvements in and relating to a process for the manufacture of mixed esters of cellulose and of films thereof
GB811770A (en) Method for hydrolyzing dextran
GB590907A (en) Improved process of manufacturing tanning extract from concentrated sulphite cellulose waste liquor
GB711307A (en) Improvements in or relating to a new derivative of ยช -pyridine aldehyde
ES211030A1 (en) A new amine salt of penicillin g