GB629439A - A process for the manufacture of 2:3:4-triaminopyridine - Google Patents

A process for the manufacture of 2:3:4-triaminopyridine

Info

Publication number
GB629439A
GB629439A GB2586647A GB2586647A GB629439A GB 629439 A GB629439 A GB 629439A GB 2586647 A GB2586647 A GB 2586647A GB 2586647 A GB2586647 A GB 2586647A GB 629439 A GB629439 A GB 629439A
Authority
GB
United Kingdom
Prior art keywords
pyridine
ammonia
dihydroxy
product
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2586647A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to GB2586647A priority Critical patent/GB629439A/en
Publication of GB629439A publication Critical patent/GB629439A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

2 : 3 : 4-Triamino-pyridine is obtained by nitrating 2 : 4-dihydroxy-pyridine, treating the product with phosphorus oxychloride to give 2 : 4-dichloro-3-nitro-pyridine, replacing the chlorine atoms by amino groups with ammonia (preferably alcoholic) and finally reducing the nitro group to an amino group. The reduction is preferably effected with aqueous sodium sulphide. The product may be converted into the picrate and the dehydrochloride, from which the free base is regenerated with ammonia. 2 : 4-Dihydroxy-pyridine is obtained by condensing acetone dicarboxylic acid diethyl ester with ethyl orthoformate and ammonia in the presence of acetic anhydride with subsequent saponification and decarboxylation.
GB2586647A 1947-09-23 1947-09-23 A process for the manufacture of 2:3:4-triaminopyridine Expired GB629439A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2586647A GB629439A (en) 1947-09-23 1947-09-23 A process for the manufacture of 2:3:4-triaminopyridine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2586647A GB629439A (en) 1947-09-23 1947-09-23 A process for the manufacture of 2:3:4-triaminopyridine

Publications (1)

Publication Number Publication Date
GB629439A true GB629439A (en) 1949-09-20

Family

ID=10234634

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2586647A Expired GB629439A (en) 1947-09-23 1947-09-23 A process for the manufacture of 2:3:4-triaminopyridine

Country Status (1)

Country Link
GB (1) GB629439A (en)

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