GB617190A - Esters of salicyclic acid - Google Patents

Esters of salicyclic acid

Info

Publication number
GB617190A
GB617190A GB16248/46A GB1624846A GB617190A GB 617190 A GB617190 A GB 617190A GB 16248/46 A GB16248/46 A GB 16248/46A GB 1624846 A GB1624846 A GB 1624846A GB 617190 A GB617190 A GB 617190A
Authority
GB
United Kingdom
Prior art keywords
dimethylpiperidino
propyl
prepared
esterification
treated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16248/46A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB617190A publication Critical patent/GB617190A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

3 - (21 : 61 - Dimethylpiperidino) - propyl salicylate <FORM:0617190/IV(b)/1> and its acid addition salts are prepared by esterification, e.g. by the reaction preferably in an inert solvent of a salicylyl halide with 3-(21 : 61-dimethylpiperidino)-propyl alcohol or of salicylic acid with a 3-(21 : 61-dimethylpiperidino)-propyl halide, to give in each case the hydrohalide salt which is convertible to the free ester by treatment with alkali. Other salts of the ester may be prepared by treating it with the appropriate acid. The compounds may be used as an thetics. In examples: (1) 3-(21 : 61-dimethylpiperidino)-propyl chloride is treated with salicylic acid in isopropanol to produce 3 - (21 : 61 - dimethylpiperidino) - propyl salicylate hydrochloride, and (2) the product prepared by the method of (1) is treated with aqueous sodium hydroxide to liberate the free base. The Specification as open to inspection under Sect. 91 comprises also the preparation of the products by processes of trans-esterification, condensation and replacement. This subject-matter does not appear in the Specification as accepted.
GB16248/46A 1945-06-30 1946-05-28 Esters of salicyclic acid Expired GB617190A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US617190XA 1945-06-30 1945-06-30

Publications (1)

Publication Number Publication Date
GB617190A true GB617190A (en) 1949-02-02

Family

ID=22037662

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16248/46A Expired GB617190A (en) 1945-06-30 1946-05-28 Esters of salicyclic acid

Country Status (1)

Country Link
GB (1) GB617190A (en)

Similar Documents

Publication Publication Date Title
GB735408A (en) Chlorotoloxy-ethyl sulphates
GB617190A (en) Esters of salicyclic acid
GB617191A (en) Preparation of substituted benzoic acid esters and salts thereof
GB1030308A (en) Process for the isolation of aromatic nitrosulfonic acids
GB716481A (en) Preparation of organic salts
GB848410A (en) Improvements in or relating to dipeptide derivatives
FR63704E (en) Process for stabilizing the salts of paraaminosalicylic acid in aqueous solution
GB393266A (en) Improvements relating to the production of water-free ethyl alcohol
GB683483A (en) 4-methylbenzhydryl dimethylaminoethyl ether and a process of preparing the same
ES309491A3 (en) Procedure for preparation of vinylloxiarene-sulphonic derivatives. (Machine-translation by Google Translate, not legally binding)
GB818896A (en) A new derivative of deserpidine and salts thereof and a process for their manufacture
GB430130A (en) A process for the production of difficultly dissociable acyl derivatives of salicylic acid and its esters
GB789788A (en) A method for the preparation of n-ú¯-butyl-n-(ú­-acetamido-benzene-sulfonyl)-urea
GB664455A (en) Manufacture of ido-pyrimidyl-mercapto-carboxylic acids and derivatives thereof
FR1019631A (en) Process for stabilizing the salts of paraaminosalicylic acid in aqueous solution
GB822720A (en) Production of xanthene derivatives
BE506317A (en) PROCESS FOR PREPARING NICOTINIC ACID ESTERS.
GB795184A (en) Soluble adrenochrome derivatives and their process of preparation
ES415453A1 (en) Procedure for the preparation of n (dietillaminoetil) - 2 - metoxi - 5 - metilsulfonil - benzamida. (Machine-translation by Google Translate, not legally binding)
GB439935A (en) Process for the manufacture of stable solutions of dihydroxy-diamino-arsenobenzene and its derivatives
GB1035382A (en) Process for the preparation of -hydroxy, ª‰-mercaptoalkane carboxylic acids or salts thereof
GB479447A (en) Improvements in the manufacture of arylaminonaphthalene derivatives
GB744379A (en) Stable, injectable solutions of 1-phenyl-2.3-dialkyl-4-dialkylamino-5-pyrazolones and process for their preparation
GB778947A (en) Process for the dehydration of dimethylphenylcarbinol
GB720166A (en) Method of preparing the tri-p-aminosalicylate of dihydrostreptomycin