GB744379A - Stable, injectable solutions of 1-phenyl-2.3-dialkyl-4-dialkylamino-5-pyrazolones and process for their preparation - Google Patents
Stable, injectable solutions of 1-phenyl-2.3-dialkyl-4-dialkylamino-5-pyrazolones and process for their preparationInfo
- Publication number
- GB744379A GB744379A GB12750/53A GB1275053A GB744379A GB 744379 A GB744379 A GB 744379A GB 12750/53 A GB12750/53 A GB 12750/53A GB 1275053 A GB1275053 A GB 1275053A GB 744379 A GB744379 A GB 744379A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- pyrazolone
- solution
- carboxylic acid
- dialkylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention comprises a stable, injectable, aqueous solution containing a 1-phenyl-2,3-dialkyl - 4 - dialkylamino - 5 - pyrazolone and an alkali metal salt of phenoxyacetic acid o-carboxylic acid amide. It also comprises a process for the preparation of such a solution, in which the 1-phenyl-2,3-dialkyl-4-dialkylamino-5-pyrazolone is dissolved in water in the presence of an alkali metal salt of phenoxy-acetic acid o-carboxylic acid amide. The two solid compounds may be dissolved together or in turn. Addition compounds, more soluble than the original pyrazolones, are apparently formed and may be isolated as a readily soluble solid by evaporating the solutions to dryness. In examples: (1) and (2) 1-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolone is dissolved in a hot aqueous solution of the sodium salt of phenoxyacetic acid o-carboxylic acid amide. The solution is charcoal treated, diluted, filled into ampoules and sterilized; (3) a solution similarly prepared to examples (1) and (2) is evaporated to dryness in vacuo and the product dried at 80 DEG C.ALSO:A stable injectable, aqueous solution contains a 1-phenyl - 2, 3 - dialkyl - 4 - dialkylamino -5-pyrazolone and an alkali metal salt of phenoxyacetic acid o-carboxylic acid amide. The two solid compounds may be dissolved together or one after the other. Addition compounds, more soluble than the original pyrazolones, are apparently formed and may be isolated as a readily-soluble solid by evaporating the solutions to dryness. In examples (1) and (2) 1-phenyl 2, 3-dimethyl-4-dimethyl-amino-5-pyrazolone is dissolved in a hot aqueous solution of the sodium salt of phenoxy-acetic acid o-carboxylic acid amide. The solution is charcoal treated, diluted, filled into ampoules and sterilised; (3) a solution prepared similarly is evaporated to dryness in vacuo and the product heated at 80 DEG C.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE744379X | 1952-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB744379A true GB744379A (en) | 1956-02-08 |
Family
ID=6648146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB12750/53A Expired GB744379A (en) | 1952-05-07 | 1953-05-07 | Stable, injectable solutions of 1-phenyl-2.3-dialkyl-4-dialkylamino-5-pyrazolones and process for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB744379A (en) |
-
1953
- 1953-05-07 GB GB12750/53A patent/GB744379A/en not_active Expired
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