GB743048A - Improvements in or relating to pregnene derivatives - Google Patents
Improvements in or relating to pregnene derivativesInfo
- Publication number
- GB743048A GB743048A GB32300/53A GB3230053A GB743048A GB 743048 A GB743048 A GB 743048A GB 32300/53 A GB32300/53 A GB 32300/53A GB 3230053 A GB3230053 A GB 3230053A GB 743048 A GB743048 A GB 743048A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aldehyde
- bisulphite
- alkaline earth
- earth metal
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises the alkali metal and alkaline earth metal bisulphite addition products of D 4-3,11,20-triketo-17a -hydroxypregnene-21-aldehyde (cortisone-21-aldehyde) and D 4 - 3,20 - diketo - 11b ,17a - dihydroxypregnene - 21 - aldehyde (hydrocortisone - 21 - aldehyde) and the preparation thereof by reacting an alkali metal or alkaline earth metal bisulphite with the required 21-aldehyde. The reaction is preferably effected by reacting the 21-aldehyde with an aqueous solution of the bisulphite salt, e.g. the aldehyde, or the monohydrate salt thereof, dissolved in an inert organic solvent, may be added to an aqueous solution of the bisulphite-a water miscible organic solvent such as a lower alcohol, acetone or dioxane being preferably used for the aldehyde. The desired product may be isolated by distilling off the organic solvent and then evaporating the water, or after removal of the organic solvent the aqueous solution may be freeze dried. The alkaline earth metal bisulphite addition products may be prepared also by reacting an alkali metal bisulphite addition product with an alkaline earth metal salt in an aqueous medium. In the examples the sodium, potassium, magnesium and calcium bisulphite addition products of cortisone-21-aldehyde and the sodium bisulphite addition product of hydrocontisone-21-aldehyde are prepared. The potassium, calcium and magnesium bisulphite addition products of hydrocortisone-21-aldehyde are also referred to.ALSO:An injectable therapeutic composition comprises a solution of an alkali metal or alkaline earth metal bisulphite addition product of D 4-3, 11, 20 - triketo - 17 - a - hydroxypregnene - 21 - aldehyde (cortisone - 21 - aldehyde) or D 4 - 3, 20 - diketo - 11b , 17a - dihydroxypregnene - 21 - aldehyde (hydrocortisone - 21 - aldehyde) in a sterile liquid, e.g. water.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US743048XA | 1952-11-24 | 1952-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB743048A true GB743048A (en) | 1956-01-04 |
Family
ID=22118867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32300/53A Expired GB743048A (en) | 1952-11-24 | 1953-11-20 | Improvements in or relating to pregnene derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB743048A (en) |
-
1953
- 1953-11-20 GB GB32300/53A patent/GB743048A/en not_active Expired
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