GB953830A - A process for the resolution of racemic homocysteic acids - Google Patents

A process for the resolution of racemic homocysteic acids

Info

Publication number
GB953830A
GB953830A GB42098/62A GB4209862A GB953830A GB 953830 A GB953830 A GB 953830A GB 42098/62 A GB42098/62 A GB 42098/62A GB 4209862 A GB4209862 A GB 4209862A GB 953830 A GB953830 A GB 953830A
Authority
GB
United Kingdom
Prior art keywords
solution
optically active
isomer
racemic
racemate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB42098/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of GB953830A publication Critical patent/GB953830A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DL-Homocysteic acid or the monoammonium last thereof is optically resolved by making and maintaining a supersaturated aqueous solution of the racemate or of the racemate and a small amount of optically active isomer, crystallizing an optically active isomer from the solution in the presence of crystals of optically active isomer and separating the crystals from the solution. After the crystals have been separated from the solution, more racemate or the other isomer is added thereto and this other isomer is then crystallized out and separated from the solution. Pure optically active homocysteic acid or the monoammonium salt thereof is obtained by dissolving optically active homocysteic acid which is contaminated with racemic acid in sufficient water, aqueous mineral acid, aqueous alkali or mixed solvent of water and a water-soluble organic solvent to dissolve the racemic component completely to form a solution which is at least substantially saturated with respect to the racemic component, and separating the optically active component remaining as a solid phase from the liquid phase.
GB42098/62A 1961-11-08 1962-11-07 A process for the resolution of racemic homocysteic acids Expired GB953830A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3972261 1961-11-08
JP4112961 1961-11-16

Publications (1)

Publication Number Publication Date
GB953830A true GB953830A (en) 1964-04-02

Family

ID=26379091

Family Applications (1)

Application Number Title Priority Date Filing Date
GB42098/62A Expired GB953830A (en) 1961-11-08 1962-11-07 A process for the resolution of racemic homocysteic acids

Country Status (2)

Country Link
CH (1) CH401082A (en)
GB (1) GB953830A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0090866A1 (en) * 1982-04-02 1983-10-12 Showa Denko Kabushiki Kaisha Optical resolution process for DL-cysteine

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211127C1 (en) * 1982-03-26 1983-08-11 Degussa Ag, 6000 Frankfurt Process for the production of S- (carboxymethyl) - (R) -cysteine and S- (carboxymethyl) - (S) -cysteine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0090866A1 (en) * 1982-04-02 1983-10-12 Showa Denko Kabushiki Kaisha Optical resolution process for DL-cysteine

Also Published As

Publication number Publication date
CH401082A (en) 1965-10-31

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