GB1091695A - Therapeutically active compounds obtainable from valerianaceae - Google Patents
Therapeutically active compounds obtainable from valerianaceaeInfo
- Publication number
- GB1091695A GB1091695A GB46666A GB46666A GB1091695A GB 1091695 A GB1091695 A GB 1091695A GB 46666 A GB46666 A GB 46666A GB 46666 A GB46666 A GB 46666A GB 1091695 A GB1091695 A GB 1091695A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acids
- isovaleroyloxy
- valerianaceae
- lipophilic solvents
- active compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Novel compounds of formula <FORM:1091695/C2/1> where either R1 and R2 are both isovaleroyloxy and the 5-6 position is saturated, or one of R/R2 is isovaleroyloxy and the other is b -acetoxy-isovaleroyloxy and the 5-6 position is as shown, are extracted from roots and rhizomes of plants of the species Valerianaceae, by using lipophilic solvents below 30 DEG C., and in the presence of 2-6 C aliphatic carboxylic acids (hereafter referred to as "acids"), in the pH range 3-7. The concentrated extracts are dissolved in acids, and fats, oils and higher hydrocarbons removed with the lipophilic solvents. After gradual dilution with water the required novel compounds are extracted from the acid solution using the lipophilic solvents, and are isolated by crystallization or chromatography using Al2O3 which has been partially deactivated by treatment with acids. IR and NMR spectra (not shown) are given for each novel compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP1717101.6-4A DE1301433B (en) | 1965-01-15 | 1965-01-15 | Process for the production of therapeutically active compounds from Valerianaceae |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1091695A true GB1091695A (en) | 1967-11-22 |
Family
ID=7227325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB46666A Expired GB1091695A (en) | 1965-01-15 | 1966-01-05 | Therapeutically active compounds obtainable from valerianaceae |
Country Status (12)
| Country | Link |
|---|---|
| BE (1) | BE675165A (en) |
| BR (1) | BR6676415D0 (en) |
| CH (1) | CH530979A (en) |
| DE (1) | DE1301433B (en) |
| DK (1) | DK115347B (en) |
| FI (1) | FI44003B (en) |
| FR (1) | FR5640M (en) |
| GB (1) | GB1091695A (en) |
| IL (1) | IL24938A (en) |
| NL (1) | NL141186B (en) |
| NO (2) | NO116435B (en) |
| SE (2) | SE349940B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5211948A (en) * | 1988-10-12 | 1993-05-18 | Nestec S.A. | Process for the preparation of a powdered extract of valerian roots |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE61919B1 (en) * | 1988-10-12 | 1994-11-30 | Nestle Sa | "Process for the preparation of a powdered extract of valerian roots" |
-
1965
- 1965-01-15 DE DEP1717101.6-4A patent/DE1301433B/en active Pending
-
1966
- 1966-01-05 GB GB46666A patent/GB1091695A/en not_active Expired
- 1966-01-07 IL IL2493866A patent/IL24938A/en unknown
- 1966-01-14 NO NO16124866A patent/NO116435B/no unknown
- 1966-01-14 DK DK21166A patent/DK115347B/en unknown
- 1966-01-14 SE SE51966A patent/SE349940B/xx unknown
- 1966-01-14 FI FI10166A patent/FI44003B/fi active
- 1966-01-14 BR BR17641566A patent/BR6676415D0/en unknown
- 1966-01-14 NL NL6600501A patent/NL141186B/en not_active IP Right Cessation
- 1966-01-14 BE BE675165D patent/BE675165A/xx not_active IP Right Cessation
- 1966-01-15 FR FR46027A patent/FR5640M/fr not_active Expired
- 1966-01-17 CH CH58466A patent/CH530979A/en not_active IP Right Cessation
-
1967
- 1967-09-14 NO NO16973967A patent/NO117492B/no unknown
-
1968
- 1968-01-19 SE SE731/68A patent/SE343211B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5211948A (en) * | 1988-10-12 | 1993-05-18 | Nestec S.A. | Process for the preparation of a powdered extract of valerian roots |
Also Published As
| Publication number | Publication date |
|---|---|
| BR6676415D0 (en) | 1973-09-06 |
| FR5640M (en) | 1967-12-26 |
| NL141186B (en) | 1974-02-15 |
| FI44003B (en) | 1971-04-30 |
| NO116435B (en) | 1969-03-24 |
| BE675165A (en) | 1966-05-03 |
| IL24938A (en) | 1969-11-30 |
| CH530979A (en) | 1972-11-30 |
| DE1301433B (en) | 1969-08-21 |
| SE343211B (en) | 1972-03-06 |
| NL6600501A (en) | 1966-07-18 |
| DK115347B (en) | 1969-09-29 |
| NO117492B (en) | 1969-08-18 |
| SE349940B (en) | 1972-10-16 |
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