GB1091695A - Therapeutically active compounds obtainable from valerianaceae - Google Patents

Therapeutically active compounds obtainable from valerianaceae

Info

Publication number
GB1091695A
GB1091695A GB46666A GB46666A GB1091695A GB 1091695 A GB1091695 A GB 1091695A GB 46666 A GB46666 A GB 46666A GB 46666 A GB46666 A GB 46666A GB 1091695 A GB1091695 A GB 1091695A
Authority
GB
United Kingdom
Prior art keywords
acids
isovaleroyloxy
valerianaceae
lipophilic solvents
active compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46666A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kali Chemie AG
Original Assignee
Kali Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie AG filed Critical Kali Chemie AG
Publication of GB1091695A publication Critical patent/GB1091695A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/84Valerianaceae (Valerian family), e.g. valerian
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Novel compounds of formula <FORM:1091695/C2/1> where either R1 and R2 are both isovaleroyloxy and the 5-6 position is saturated, or one of R/R2 is isovaleroyloxy and the other is b -acetoxy-isovaleroyloxy and the 5-6 position is as shown, are extracted from roots and rhizomes of plants of the species Valerianaceae, by using lipophilic solvents below 30 DEG C., and in the presence of 2-6 C aliphatic carboxylic acids (hereafter referred to as "acids"), in the pH range 3-7. The concentrated extracts are dissolved in acids, and fats, oils and higher hydrocarbons removed with the lipophilic solvents. After gradual dilution with water the required novel compounds are extracted from the acid solution using the lipophilic solvents, and are isolated by crystallization or chromatography using Al2O3 which has been partially deactivated by treatment with acids. IR and NMR spectra (not shown) are given for each novel compound.
GB46666A 1965-01-15 1966-01-05 Therapeutically active compounds obtainable from valerianaceae Expired GB1091695A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEP1717101.6-4A DE1301433B (en) 1965-01-15 1965-01-15 Process for the production of therapeutically active compounds from Valerianaceae

Publications (1)

Publication Number Publication Date
GB1091695A true GB1091695A (en) 1967-11-22

Family

ID=7227325

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46666A Expired GB1091695A (en) 1965-01-15 1966-01-05 Therapeutically active compounds obtainable from valerianaceae

Country Status (12)

Country Link
BE (1) BE675165A (en)
BR (1) BR6676415D0 (en)
CH (1) CH530979A (en)
DE (1) DE1301433B (en)
DK (1) DK115347B (en)
FI (1) FI44003B (en)
FR (1) FR5640M (en)
GB (1) GB1091695A (en)
IL (1) IL24938A (en)
NL (1) NL141186B (en)
NO (2) NO116435B (en)
SE (2) SE349940B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211948A (en) * 1988-10-12 1993-05-18 Nestec S.A. Process for the preparation of a powdered extract of valerian roots

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE61919B1 (en) * 1988-10-12 1994-11-30 Nestle Sa "Process for the preparation of a powdered extract of valerian roots"

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211948A (en) * 1988-10-12 1993-05-18 Nestec S.A. Process for the preparation of a powdered extract of valerian roots

Also Published As

Publication number Publication date
BR6676415D0 (en) 1973-09-06
FR5640M (en) 1967-12-26
NL141186B (en) 1974-02-15
FI44003B (en) 1971-04-30
NO116435B (en) 1969-03-24
BE675165A (en) 1966-05-03
IL24938A (en) 1969-11-30
CH530979A (en) 1972-11-30
DE1301433B (en) 1969-08-21
SE343211B (en) 1972-03-06
NL6600501A (en) 1966-07-18
DK115347B (en) 1969-09-29
NO117492B (en) 1969-08-18
SE349940B (en) 1972-10-16

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