GB833149A - Rauwolfia alkaloids and their extraction - Google Patents

Rauwolfia alkaloids and their extraction

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Publication number
GB833149A
GB833149A GB12014/58A GB1201458A GB833149A GB 833149 A GB833149 A GB 833149A GB 12014/58 A GB12014/58 A GB 12014/58A GB 1201458 A GB1201458 A GB 1201458A GB 833149 A GB833149 A GB 833149A
Authority
GB
United Kingdom
Prior art keywords
alkaloids
raugustine
raunescine
acetyl
extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12014/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB833149A publication Critical patent/GB833149A/en
Expired legal-status Critical Current

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Abstract

The invention comprises Raugustine of the formula <FORM:0833149/IV (b)/1> its esters, and salts thereof, together with a process for isolating weakly basic alkaloids of the raunescine series wherein an aqueous solution of a weak acid containing alkaloids of the raunescine group in admixture with other alkaloids from Rauwolfia plants is extracted with benzene (or other organic solvent having similar extraction properties for the alkaloids) to remove the reserpine alkaloids and the greater part of the ajmalicine alkaloids, the residual aqueous solution is extracted with ethylene chloride (or other organic solvent of similar action) to obtain the raunescine alkaloids, which are isolated if desired in pure form by adsorption, elution or crystallization of the mixture so obtained. Detailed examples illustrate the extraction of raugustine, raunescine, isoraunescine, reserpiline and pseudoreserpine from various Rauwolfia species, and the preparation of 18-O-acetyl-raugustine and raugustine nitrate. The conversion of raugustine to 17-acetyl-pseudorescopine by treatment with pyridine hydrochloride, then sodium methylate, acetylation to methyl 17-acetyl pseudoreserpic acid ester and esterification with trimethoxybenzoyl chloride is described.
GB12014/58A 1957-04-15 1958-04-15 Rauwolfia alkaloids and their extraction Expired GB833149A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH833149X 1957-04-15

Publications (1)

Publication Number Publication Date
GB833149A true GB833149A (en) 1960-04-21

Family

ID=4540465

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12014/58A Expired GB833149A (en) 1957-04-15 1958-04-15 Rauwolfia alkaloids and their extraction

Country Status (1)

Country Link
GB (1) GB833149A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3247183A (en) * 1966-04-19 New process for the manufacture of yohimbane compounds
WO2010113180A3 (en) * 2009-03-31 2010-12-16 Council Of Scientific & Industrial Research Antipsychotic agents and standardized antipsychotic fractions from rauwolfia tetraphylla and process of their isolation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3247183A (en) * 1966-04-19 New process for the manufacture of yohimbane compounds
WO2010113180A3 (en) * 2009-03-31 2010-12-16 Council Of Scientific & Industrial Research Antipsychotic agents and standardized antipsychotic fractions from rauwolfia tetraphylla and process of their isolation
GB2481179A (en) * 2009-03-31 2011-12-14 Council Scient Ind Res Antipsychotic agents and standardized antipsychotic fractions from rauwolfia tetraphylla and process of their isolation
GB2481179B (en) * 2009-03-31 2014-04-09 Council Scient Ind Res Antipsychotic agents and standardized antipsychotic fractions from Rauwolfia tetraphylla and process of their isolation

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