GB788373A - Water-soluble derivatives of 5-nitro furfural and production thereof - Google Patents
Water-soluble derivatives of 5-nitro furfural and production thereofInfo
- Publication number
- GB788373A GB788373A GB25380/55A GB2538055A GB788373A GB 788373 A GB788373 A GB 788373A GB 25380/55 A GB25380/55 A GB 25380/55A GB 2538055 A GB2538055 A GB 2538055A GB 788373 A GB788373 A GB 788373A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nitro
- piperazine
- furfurylidene
- water
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
The invention comprises addition compounds of two mols. of a piperazine and one mol. of 5-nitro - furfural semicarbazone, N - (5 - nitro-2 - furfurylidene) - 1 - aminohydantoine or N-(5-nitro - 2 - furfurylidene) - 3 - amino oxazolidone. The novel compounds may be prepared by reacting a piperazine with one of the abovementioned 5-nitro-furfurylidene compounds in the molar proportion of 2:1 in an inert diluent, for example water or an anhydrous organic medium such as pure ethanol, at an elevated temperature below 100 DEG C., say about 80 DEG C., after which the reaction mixture may be evaporated to dryness in the presence of a dehydrating agent. It is desirable to evaporate the reaction solution in vacuum to obtain a syrup and then to spread the latter in film form, say over plates, and complete drying in a vacuum over sulphuric acid. Piperazine may be used in the form of piperazine hydrate. Alkyl piperazines such as methyl and dimethyl piperazines may also be used. The products are useful water-soluble bactericidal compounds (see Group VI).ALSO:A bactericidal composition comprises an aqueous solution of an addition compound of 2 mols. of piperazine, or an alkyl piperazine, and 1 mol. of 5-nitro-furfural semicarbazone, N - (5 - nitro - 2 - furfurylidene) - 1 - aminohydantoine or N - (5 - nitro - 2 - furfurylidene)-3-amino oxazolidone (for preparation see Group IV (b)). The compositions are useful for preventing and curing infectious diseases of poultry. Thus the addition compounds of piperazine and either 5-nitrofurfural-semicarbazone or N - (5 - nitro - 2 - furfurylidene) 3-amine oxazolidone in doses of 1.5 gm. per 100 gm. of water are active against coccidiosis, pullorosis and diphtheria of poultry. The aqueous solutions may also be used for treating bee dysentery. A syrup of 100 gm. of an aqueous solution containing 1.5 per cent of the addition compound, and 90 gm. of sugar is suitable for this purpose. Aqueous solutions containing 1 part of an addition compound of piperazine and 5-nitro-furfural semicarbazone in 150,000 parts of water prevent the development of cocci, anaerobia and Gram positive bacilli, and provide a good disinfectant for wounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR788373X | 1954-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB788373A true GB788373A (en) | 1958-01-02 |
Family
ID=9219495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB25380/55A Expired GB788373A (en) | 1954-09-08 | 1955-09-05 | Water-soluble derivatives of 5-nitro furfural and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB788373A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3007846A (en) * | 1959-03-04 | 1961-11-07 | Norwich Pharma Co | Alkali metal salts of nitrofurantoin |
| US3157645A (en) * | 1961-12-06 | 1964-11-17 | Norwich Pharma Co | 3-alkenyl or alkinyl 1-(5-nitrofur-furylideneamino) hydantoins |
| US3234220A (en) * | 1962-03-31 | 1966-02-08 | Boehringer & Soehne Gmbh | Tasteless n-(5-nitrofurfurylidene)-1-aminohydantoin salts |
-
1955
- 1955-09-05 GB GB25380/55A patent/GB788373A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3007846A (en) * | 1959-03-04 | 1961-11-07 | Norwich Pharma Co | Alkali metal salts of nitrofurantoin |
| US3157645A (en) * | 1961-12-06 | 1964-11-17 | Norwich Pharma Co | 3-alkenyl or alkinyl 1-(5-nitrofur-furylideneamino) hydantoins |
| US3234220A (en) * | 1962-03-31 | 1966-02-08 | Boehringer & Soehne Gmbh | Tasteless n-(5-nitrofurfurylidene)-1-aminohydantoin salts |
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