GB594415A - Improvements in or relating to process for the preparation of 5,7-dichloro-8-hydroxy-quinaldine - Google Patents
Improvements in or relating to process for the preparation of 5,7-dichloro-8-hydroxy-quinaldineInfo
- Publication number
- GB594415A GB594415A GB670/45A GB67045A GB594415A GB 594415 A GB594415 A GB 594415A GB 670/45 A GB670/45 A GB 670/45A GB 67045 A GB67045 A GB 67045A GB 594415 A GB594415 A GB 594415A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dichloro
- hydroxyquinaldine
- aminophenol
- chloro
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
5 : 7 - Dichloro - 8 - hydroxyquinaldine, which has bactericidal properties, is manufactured by reacting 4 : 6-dichloro-2-aminophenol with acetaldehyde, paraldehyde, aldol, acetal, crotonaldehyde or lactic acid in the presence of a strong acid, e.g. hydrochloric or sulphuric acid and preferably with the addition of zinc, tin or aluminium or a salt thereof with a strong acid, e.g. zinc chloride, tin tetrachloride or aluminium chloride; or by treating 4-chloro-2-aminophenol similarly to produce 5-chloro-8-hydroxyquinaldine and chlorinating this in acid solution. In an example, 4 : 6-dichloro-2-aminophenol is allowed to stand, or heated under reflux, with paraldehyde, hydrochloric acid and aluminium chloride. A sample has been furnished under Sect. 2(5) of 5 : 7-dichloro-8-hydroxyquinaldine prepared by treating 4-chloro-2-aminophenol as in the example above, and treating the resulting 5-chloro-8-hydroxyquinaldine with chlorine in hydrochloric acid at 40-55 DEG C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH594415X | 1943-12-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB594415A true GB594415A (en) | 1947-11-11 |
Family
ID=4522334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB670/45A Expired GB594415A (en) | 1943-12-31 | 1945-01-08 | Improvements in or relating to process for the preparation of 5,7-dichloro-8-hydroxy-quinaldine |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB594415A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL422265A1 (en) * | 2017-07-18 | 2019-01-28 | Valeant Pharmaceuticals Ireland | Method for producing chloroquinaldol with increased purity |
-
1945
- 1945-01-08 GB GB670/45A patent/GB594415A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL422265A1 (en) * | 2017-07-18 | 2019-01-28 | Valeant Pharmaceuticals Ireland | Method for producing chloroquinaldol with increased purity |
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