PL422265A1 - Method for producing chloroquinaldol with increased purity - Google Patents

Method for producing chloroquinaldol with increased purity

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Publication number
PL422265A1
PL422265A1 PL422265A PL42226517A PL422265A1 PL 422265 A1 PL422265 A1 PL 422265A1 PL 422265 A PL422265 A PL 422265A PL 42226517 A PL42226517 A PL 42226517A PL 422265 A1 PL422265 A1 PL 422265A1
Authority
PL
Poland
Prior art keywords
chloroquinaldol
producing
increased purity
neutralized
purified
Prior art date
Application number
PL422265A
Other languages
Polish (pl)
Inventor
Elżbieta DĄBROWSKA-MAŚ
Wojciech RAŚ
Bartłomiej ATAMAN
Kazimierz SMOLAK
Adam PSZENICZNY
Original Assignee
Valeant Pharmaceuticals Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeant Pharmaceuticals Ireland filed Critical Valeant Pharmaceuticals Ireland
Priority to PL422265A priority Critical patent/PL422265A1/en
Publication of PL422265A1 publication Critical patent/PL422265A1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania chlorochinaldolu o podwyższonej czystości. Przedmiotowy sposób charakteryzuje się tym, że chlorowodorek chlorochinaldolu tworzący się w reakcji chlorowania 8-hydroksychinaldyny izoluje się z mieszaniny reakcyjnej, oczyszcza i poddaje neutralizacji do chlorochinaldolu. W drugiej odmianie wynalazku chlorowodorek chlorochinaldolu tworzący się w reakcji chlorowania 7-chloro-8-hydroksychinaldyny izoluje się z mieszaniny reakcyjnej, oczyszcza, i poddaje neutralizacji do chlorochinaldolu. W kolejnej odmianie zgłoszenia sposób wytwarzania chlorochinaldolu o podwyższonej czystości, charakteryzuje się tym, że chlorochinaldol otrzymany w wyniku chlorowania 7-chloro-8-hydroksychinaldyny gazowym chlorem przeprowadza się w sól addycyjną chlorochinaldolu, którą oczyszcza się i poddaje neutralizacji do chlorochinaldolu. W czwartej odmianie wynalazku sposób wytwarzania chlorochinaldolu o podwyższonej czystości, charakteryzuje się tym, że chlorochinaldol otrzymany znanymi sposobami przeprowadza się w sól addycyjną chlorochinaldolu, którą oczyszcza się i poddaje neutralizacji do chlorochinaldolu.The subject of the application is a method for producing chlorochinaldol with increased purity. The subject method is characterized in that chlorochinaldol hydrochloride formed in the chlorination reaction of 8-hydroxyquinidine is isolated from the reaction mixture, purified and neutralized to chloroquindol. In a second embodiment of the invention, chlorochinaldol hydrochloride formed in the chlorination reaction of 7-chloro-8-hydroxychinaldine is isolated from the reaction mixture, purified, and neutralized to chloroquinaldol. In a further variation of the application, the method for producing chloroquinaldol with increased purity is characterized in that chloroquinaldol obtained as a result of chlorination of 7-chloro-8-hydroxychinaldine with chlorine gas is converted into the chloroquinaldol addition salt, which is purified and neutralized to chloroquinaldol. In a fourth embodiment of the invention, the method for producing chloroquinaldol with increased purity is characterized in that the chloroquinaldol obtained by known methods is converted into a chloroquinaldol addition salt, which is purified and neutralized to chloroquinaldol.

PL422265A 2017-07-18 2017-07-18 Method for producing chloroquinaldol with increased purity PL422265A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL422265A PL422265A1 (en) 2017-07-18 2017-07-18 Method for producing chloroquinaldol with increased purity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL422265A PL422265A1 (en) 2017-07-18 2017-07-18 Method for producing chloroquinaldol with increased purity

Publications (1)

Publication Number Publication Date
PL422265A1 true PL422265A1 (en) 2019-01-28

Family

ID=65033982

Family Applications (1)

Application Number Title Priority Date Filing Date
PL422265A PL422265A1 (en) 2017-07-18 2017-07-18 Method for producing chloroquinaldol with increased purity

Country Status (1)

Country Link
PL (1) PL422265A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2411670A (en) * 1946-11-26 Halogen-b-htdeoxy-qtjinaldines
GB594415A (en) * 1943-12-31 1947-11-11 Elisabeth Pfanner Improvements in or relating to process for the preparation of 5,7-dichloro-8-hydroxy-quinaldine
GB909359A (en) * 1960-02-24 1962-10-31 E R Squibb & Sons Ltd Improvements in chlorhydroxyquinoline and the production thereof
GB1154675A (en) * 1967-01-11 1969-06-11 Rutgerswerke Und Teerverwertun Chlorination.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2411670A (en) * 1946-11-26 Halogen-b-htdeoxy-qtjinaldines
GB594415A (en) * 1943-12-31 1947-11-11 Elisabeth Pfanner Improvements in or relating to process for the preparation of 5,7-dichloro-8-hydroxy-quinaldine
GB909359A (en) * 1960-02-24 1962-10-31 E R Squibb & Sons Ltd Improvements in chlorhydroxyquinoline and the production thereof
GB1154675A (en) * 1967-01-11 1969-06-11 Rutgerswerke Und Teerverwertun Chlorination.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LUCIA P. ET AL, SYNTHESIS AND SPECTROSCOPY STUDIES OF BY-PRODUCTS OF CHLOROQUINALDOL, 2016 *

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