DE835441C - Process for the production of xanthine - Google Patents

Process for the production of xanthine

Info

Publication number
DE835441C
DE835441C DEB1637A DEB0001637A DE835441C DE 835441 C DE835441 C DE 835441C DE B1637 A DEB1637 A DE B1637A DE B0001637 A DEB0001637 A DE B0001637A DE 835441 C DE835441 C DE 835441C
Authority
DE
Germany
Prior art keywords
xanthine
dioxy
production
monoformyl
diaminopyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB1637A
Other languages
German (de)
Inventor
Dr Wilhelm Konz
Dr Georg Scheuing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Priority to DEB1637A priority Critical patent/DE835441C/en
Application granted granted Critical
Publication of DE835441C publication Critical patent/DE835441C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung von Xanthin Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von Xanthin aus Monoformyl-2, 6-dioxy-4, 5-diaminopvrimidin.Process for the preparation of xanthine The present invention relates to a process for the preparation of xanthine from monoformyl-2,6-dioxy-4,5-diaminopvrimidine.

Es ist bekannt (Berichte der deutsch. Chem. Ges. Bd. 33, S 3o43 ' igool), daß man Xanthin durch Erhitzen des Mononatriumsalzes des Monoformyl-2, 6-dioxy-4, 5-diaminopyrimidins auf etwa 22o° herstellen kann. Bei diesem bekannten Verfahren ist es erforderlich, das Natriumsalz zu isolieren, zu trocknen, es trocken zu erhitzen und das Reaktionsprodukt in Wasser zu lösen und zu fällen. Diese Maßnahmen sind recht umständlich. Außerdem ist die Ausbeute bei diesem bekannten Verfahren nicht besonders gut (6o bis 7o°,',). Es wurde nun gefunden, daß man Xanthin aus Monoformyl-2, 6-dioxy-4, 5-diaminopyrimidin in fast quantitativer Ausbeute erhalten kann, wenn man es mit Formamid auf höhere Temperaturen, vorzugsweise i8o bis 2oo°, erhitzt.It is known (reports of the German. Chem. Ges. Bd. 33, S 3o43 ' igool) that xanthine can be obtained by heating the monosodium salt of monoformyl-2, 6-dioxy-4, Can produce 5-diaminopyrimidines to about 22o °. In this known method it is necessary to isolate the sodium salt, dry it, heat it dry and to dissolve and precipitate the reaction product in water. These measures are quite awkward. In addition, the yield in this known method is not especially good (6o to 7o °, ',). It has now been found that xanthine can be obtained from monoformyl-2, 6-dioxy-4, 5-diaminopyrimidine can be obtained in almost quantitative yield if it is heated to higher temperatures, preferably from 180 ° to 200 °, with formamide.

Bei der Durchführung des erfindungsmäßigen Verfahrens wird zweckmäßig eine Suspension des Monoforinyl-2, 6-dioxy-4, 5-diaminopyrimidins in etwa der fünffachen Menge Formamid 3 bis 4 Stunden auf igo° erhitzt. Dabei findet die Umwandlung der Monoformylverbindung in das Xanthin statt, ohne daß vorübergehend Lösung zu beobachten ist. Nach Erkalten wird das Xanthin abgetrennt. Es kann nach üblichen Methoden gereinigt werden oder als solches direkt zur weiteren Verarbeitung auf Alkylxanthine, z. B. Coffein, eingesetzt werden. Die Ausbeuten an Xanthin, bezogen auf eingesetzte Formylverbindung, sind fast quantitativ.When carrying out the method according to the invention, it is expedient a suspension of monoforinyl-2, 6-dioxy-4, 5-diaminopyrimidine in about five times Amount of formamide heated to igo ° for 3 to 4 hours. The conversion of the Monoformyl compound takes place in the xanthine without any temporary dissolution being observed is. After cooling, the xanthine is separated off. It can be cleaned using standard methods be or as such directly for further processing on alkylxanthines, z. B. caffeine can be used. The yields of xanthine, based on the used Formyl compound, are almost quantitative.

Im folgenden soll die Durchführung des erfindungsmäßigen Verfahrens an Hand eines Ausführungsbeispiels näher erläutert werden.In the following, the implementation of the inventive method are explained in more detail using an exemplary embodiment.

Beispiel 15 Teile hionoformyl-2, 6-dioxy-4, 5-diaminopyrimidin werden in 75 Teilen Formamid suspendiert und 3 bis 4 Stunden in schwachem Sieden gehalten. Temperatur etwa igo°. :Nach der angegebenen Zeit trennt man das Xanthin ab. Man erhält 13,2 Teile Xanthin. Theoretische Ausbeute 13,4 Teile.Example 15 parts of hionoformyl-2,6-dioxy-4,5-diaminopyrimidine are suspended in 75 parts of formamide and kept at a low boiling point for 3 to 4 hours. Temperature about igo °. : After the specified time, the xanthine is separated. 13.2 parts of xanthine are obtained. Theoretical yield 13.4 parts.

Claims (1)

PATEYTAISPRUCH: Verfahren zur Herstellung von Xanthin, dadurch gekennzeichnet, daß Nlonofoi-m\l-2, 6-dioxy-4, 5-diaminopyrimidin mit Formamid auf höhere Temperaturen, vorzugsweise iSo bi; 200`, erhitzt wird.PATEYTAISPRUCH: Process for the production of xanthine, characterized in, that Nlonofoi-m \ l-2, 6-dioxy-4, 5-diaminopyrimidine with formamide to higher temperatures, preferably iSo bi; 200`, is heated.
DEB1637A 1943-10-23 1943-10-23 Process for the production of xanthine Expired DE835441C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB1637A DE835441C (en) 1943-10-23 1943-10-23 Process for the production of xanthine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB1637A DE835441C (en) 1943-10-23 1943-10-23 Process for the production of xanthine

Publications (1)

Publication Number Publication Date
DE835441C true DE835441C (en) 1952-03-31

Family

ID=6952376

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB1637A Expired DE835441C (en) 1943-10-23 1943-10-23 Process for the production of xanthine

Country Status (1)

Country Link
DE (1) DE835441C (en)

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