GB560631A - Improvements in or relating to water-soluble riboflavin compositions - Google Patents
Improvements in or relating to water-soluble riboflavin compositionsInfo
- Publication number
- GB560631A GB560631A GB6505/42A GB650542A GB560631A GB 560631 A GB560631 A GB 560631A GB 6505/42 A GB6505/42 A GB 6505/42A GB 650542 A GB650542 A GB 650542A GB 560631 A GB560631 A GB 560631A
- Authority
- GB
- United Kingdom
- Prior art keywords
- riboflavin
- sodium
- solution
- borate
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A soluble preparation containing riboflavin which is not excessively alkaline for the purpose of injection comprises at least 0.02 per cent riboflavin and an alkali metal borate in amount corresponding to at least one gram atom of boron per gram-mole of riboflavin. The alkali borate may be sodium tetra borate or sodium metaborate. Of these the former is preferred as the pH of the resulting solution is lower and the solution is more suitable for injection. The corresponding potassium salts may also be used. The ingredients may either be mixed in solution or dry intimate mixtures of sodium or potassium borates may be prepared. There may be added to the solution other vitamins or other therapeutic factors. In examples: (1) a mixture is made of riboflavin sodium hydroxide and sodium borate ( 1/100 mol. of each) in aqueous solution, and the double salt precipitated by a water miscible organic solvent such as acetone, ethyl alcohol, isopropyl alcohol, n-propyl alcohol or dioxane. (2) An aqueous solution is formed of 1/100 mol of riboflavin, potassium hydroxide and potassium borate penta hydrate and precipitated with acetone. (3) An aqueous solution is formed of 1/100 mol. of riboflavin and sodium hydroxide and to this is added 1/50 mol. of sodium metaborate. (4) 1.5 Grams of riboflavin is dissolved in 145 ccs. of 0.1 N-caustic soda and the solution mixed with a solution of 6 grams of boric acid in 200 ccs. of water. The water is removed, e.g. by freezing and the resulting dry powder obtained by evaporation in vacuo in the frozen state sealed into ampules. (5) An aqueous solution containing riboflavin and caustic soda is added to an aqueous solution containing thiamin chloride, vitamin B6, nicotinic acid amide, calcium pantothenate and boric acid. The resulting solution is evaporated to dryness with precautions to prevent decomposition such as evaporation in vacuo in the frozen state. (6) Riboflavin is mixed with sodium borate, if desired in the presence of an inert filler such as milk sugar. The mixture may be dispensed either as a powder or in tablet form. (7) Sodium borate is mixed with riboflavin, thiamin chloride, vitamin B6, calcium pantothenate, sodium nicotinate and also if desired an inert filler such as milk sugar. This mixture also may be dispensed as a powder or in tablet form.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US560631XA | 1941-04-15 | 1941-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB560631A true GB560631A (en) | 1944-04-13 |
Family
ID=22001918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB6505/42A Expired GB560631A (en) | 1941-04-15 | 1942-05-13 | Improvements in or relating to water-soluble riboflavin compositions |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB560631A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004010790A1 (en) * | 2002-07-25 | 2004-02-05 | Horvath Istvan | Sweet products with flavin content and methods of producing thereof |
-
1942
- 1942-05-13 GB GB6505/42A patent/GB560631A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004010790A1 (en) * | 2002-07-25 | 2004-02-05 | Horvath Istvan | Sweet products with flavin content and methods of producing thereof |
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