GB438408A - Process for making readily soluble complex theophylline compounds - Google Patents

Process for making readily soluble complex theophylline compounds

Info

Publication number
GB438408A
GB438408A GB1114335A GB1114335A GB438408A GB 438408 A GB438408 A GB 438408A GB 1114335 A GB1114335 A GB 1114335A GB 1114335 A GB1114335 A GB 1114335A GB 438408 A GB438408 A GB 438408A
Authority
GB
United Kingdom
Prior art keywords
mol
theophylline
ethylenediamine
acid
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1114335A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAUL REINHOLD GRUETER
Original Assignee
PAUL REINHOLD GRUETER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAUL REINHOLD GRUETER filed Critical PAUL REINHOLD GRUETER
Priority to GB1114335A priority Critical patent/GB438408A/en
Publication of GB438408A publication Critical patent/GB438408A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Complex water-soluble compounds of therapeutic value are obtained by reacting one molecular proportion of equimolecular theophylline-ethylenediamine, or its components, with not more than one-fifth of a molecular proportion of a C : C- di- or C : C : N-trisubstituted barbituric acid. The reaction may be effected by rubbing up the constituents, if desired with the addition of water or an alcohol as solvent. Examples are given of the interaction of (1) theophylline monohydrate (1 mol), 5 : 5-phenylethyl-barbituric acid (\ba1/10\be mol) and ethylenediamine hydrate (1 mol) in water; (2) theophylline-ethylenediamine monohydrate (1 mol) and 5 : 5-phenylethylbarbituric acid (\ba1/10\be mol) in water; (3) theophylline monohydrate (1 mol), 5 : 5-phenylethyl-barbituric acid (\ba1/7\be mol) and ethylenediamine hydrate (1 mol) in alcohol; (4) theophylline monohydrate (1 mol), C : C-diethylbarbituric acid (\ba1/5\be mol) and ethylenediamine hydrate (1 mol) in alcohol; following by drying in vacuo in each case. Other barbituric acids mentioned are C : C-isopropyl-b -bromallyl-, diallyl-, isopropylallyl-, phenylallyl-, and D <1\1.2>-cyclohexenylethyl-barbituric acids and C : C-phenylethyl-N-methyl-barbituric acid.
GB1114335A 1935-04-10 1935-04-10 Process for making readily soluble complex theophylline compounds Expired GB438408A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1114335A GB438408A (en) 1935-04-10 1935-04-10 Process for making readily soluble complex theophylline compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1114335A GB438408A (en) 1935-04-10 1935-04-10 Process for making readily soluble complex theophylline compounds

Publications (1)

Publication Number Publication Date
GB438408A true GB438408A (en) 1935-11-15

Family

ID=9980818

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1114335A Expired GB438408A (en) 1935-04-10 1935-04-10 Process for making readily soluble complex theophylline compounds

Country Status (1)

Country Link
GB (1) GB438408A (en)

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