GB462573A - Improvements in and relating to substituted barbituric acids - Google Patents
Improvements in and relating to substituted barbituric acidsInfo
- Publication number
- GB462573A GB462573A GB231536A GB231536A GB462573A GB 462573 A GB462573 A GB 462573A GB 231536 A GB231536 A GB 231536A GB 231536 A GB231536 A GB 231536A GB 462573 A GB462573 A GB 462573A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrazolone
- dimethyl
- phenyl
- aqueous solution
- barbiturate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Aqueous solutions of alkali metal salts of barbituric acids of the formula <FORM:0462573/IV/1> in which R1 represents an olefine radicle halogenated at the double bond, R2 an aliphatic or alicyclic radicle and R3 an aliphatic radicle, are stabilized for therapeutic purposes by the addition of a water-soluble pyrazolone, e.g. 1 - phenyl - 2 : 3 - dimethyl - 5 - pyrazolone or 1-phenyl-2 : 3-dimethyl-4-methoxy-5-pyrazolone. The barbiturate is dissolved in an aqueous solution of the pyrazolone or vice versa, or the free acid is treated in the presence of the pyrazolone with the requisite amount of aqueous caustic alkali. In the latter case the acid is preferably made into a paste with a polyhydric alcohol such as glycol or glycerine before adding the alkali solution. According to the examples: (1) sodium sec - butyl - b - chlorallyl - N - ethyl-barbiturate is dissolved in an aqueous solution of 1 - phenyl - 2 : 3 - dimethyl - 4 - methoxy - 5 - pyrazolone; (2) sec - amyl - b - bromallyl-barbituric acid is N-methylated with dimethyl sulphate, made into a paste with glycol, dissolved in caustic soda solution and an aqueous solution of 1-phenyl-2 : 3-dimethyl-5-pyrazolone then added; (3) isopropyl-b -bromallyl-N-methyl-barbituric acid is stirred with glycerine, dissolved in caustic soda solution and added to an aqueous solution of 1-phenyl-2 : 3-dimethyl-5-pyrazolone. An aqueous solution containing sodium isopropyl-b -chlorallyl-N - methyl - barbiturate and 1 - phenyl - 2 : 3-dimethyl-5-pyrazolone is also referred to. A sample has been furnished under Sect. 2 (5) of an aqueous solution of sodium isopropyl-b -bromcrotyl - N - methyl - barbiturate containing 1 - phenyl - 2 : 3 - dimethyl - 5 - pyrazolone. The barbituric acid is prepared by heating sodium isopropylbarbiturate with 1 : 2-dibrombutene-2 in aqueous solution and treating the product with dimethyl sulphate.ALSO:Aqueous solutions of alkali metal salts of barbituric acids of the formula <FORM:0462573/VI/1> in which R1 represents an olefine radicle halogenated at the double bond, R2 an aliphatic or alicyclic radicle and R3 an aliphatic radicle, are stabilized for therapeutic purposes by the addition of a water-soluble pyrazolone. The barbiturate is dissolved in an aqueous solution of the pyrazolone or vice versa, or the free acid is treated in the presence of the pyrazolone with the requisite amount of aqueous caustic alkali. In the latter case the acid is preferably made into a paste with a polyhydric alcohol such as glycol or glycerine before adding the alkali solution. Examples describe the preparation of an aqueous solution of sodium secbutyl-b -chlorallyl-N-ethyl-barbiturate containing 1 - phenyl - 2 : 3 - dimethyl - 4 - methoxy - 5 - pyrazolone, and of aqueous solutions of sodium sec - amyl - b - bromallyl - N - methyl - barbiturate and of isopropyl - b - bromallyl - N - methylbarbiturate containing 1-phenyl-2 : 3-dimethyl-5-pyrazolone. The sample furnished under Sect. 2 (5) comprises an aqueous solution of sodium isopropyl-b -bromcrotyl-N-methyl-barbiturate containing 1 - phenyl - 2 : 3 - dimethyl - 5 - pyrazolone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB231536A GB462573A (en) | 1936-01-24 | 1936-01-24 | Improvements in and relating to substituted barbituric acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB231536A GB462573A (en) | 1936-01-24 | 1936-01-24 | Improvements in and relating to substituted barbituric acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB462573A true GB462573A (en) | 1937-03-11 |
Family
ID=9737386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB231536A Expired GB462573A (en) | 1936-01-24 | 1936-01-24 | Improvements in and relating to substituted barbituric acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB462573A (en) |
-
1936
- 1936-01-24 GB GB231536A patent/GB462573A/en not_active Expired
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