GB2583625A - Microfluidic chips for particle purification and fractionation - Google Patents

Microfluidic chips for particle purification and fractionation Download PDF

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Publication number
GB2583625A
GB2583625A GB2010486.5A GB202010486A GB2583625A GB 2583625 A GB2583625 A GB 2583625A GB 202010486 A GB202010486 A GB 202010486A GB 2583625 A GB2583625 A GB 2583625A
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GB
United Kingdom
Prior art keywords
pillars
array
fluid
outlet
lattice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB2010486.5A
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English (en)
Other versions
GB202010486D0 (en
Inventor
Thomas Smith Joshua
Gifford Stacey
Kim Sung-Cheol
Hardy Wunsch Benjamin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Business Machines Corp
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International Business Machines Corp
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Filing date
Publication date
Application filed by International Business Machines Corp filed Critical International Business Machines Corp
Publication of GB202010486D0 publication Critical patent/GB202010486D0/en
Publication of GB2583625A publication Critical patent/GB2583625A/en
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1894—Cooling means; Cryo cooling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
GB2010486.5A 2018-01-19 2019-01-14 Microfluidic chips for particle purification and fractionation Withdrawn GB2583625A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/875,905 US10946380B2 (en) 2018-01-19 2018-01-19 Microfluidic chips for particle purification and fractionation
PCT/IB2019/050272 WO2019142087A1 (en) 2018-01-19 2019-01-14 Microfluidic chips for particle purification and fractionation

Publications (2)

Publication Number Publication Date
GB202010486D0 GB202010486D0 (en) 2020-08-19
GB2583625A true GB2583625A (en) 2020-11-04

Family

ID=67299122

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2010486.5A Withdrawn GB2583625A (en) 2018-01-19 2019-01-14 Microfluidic chips for particle purification and fractionation

Country Status (6)

Country Link
US (2) US10946380B2 (enExample)
JP (1) JP2021510516A (enExample)
CN (1) CN111615552B (enExample)
DE (1) DE112019000463B4 (enExample)
GB (1) GB2583625A (enExample)
WO (1) WO2019142087A1 (enExample)

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US11458474B2 (en) 2018-01-19 2022-10-04 International Business Machines Corporation Microfluidic chips with one or more vias
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US10946380B2 (en) 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
US20200316230A1 (en) * 2019-04-08 2020-10-08 Vanderbilt University Devices and methods for radiopharmaceutical synthesis
US11266989B2 (en) * 2019-08-07 2022-03-08 International Business Machines Corporation Immunodetection and separation on nanoDLD
US11517873B2 (en) 2019-10-29 2022-12-06 International Business Machines Corporation Controlled chemical synthesis using polymer substrates and nanofluidic separation systems
US11565262B2 (en) * 2020-03-10 2023-01-31 International Business Machines Corporation Continous band-pass filter size separation using a negative angle DLD array
CN111821601A (zh) * 2020-05-27 2020-10-27 深圳艾素科技有限公司 一种电子过滤装置及其操作方法
CN111778138B (zh) * 2020-07-06 2022-01-11 中南大学 一种分选血浆中外泌体的微流控器件及其使用方法
CN113652333B (zh) * 2021-08-03 2023-03-21 中国科学院上海微系统与信息技术研究所 一种优化流体分布的微柱式多相位移通道
CN114574357B (zh) * 2022-02-14 2025-11-11 大连交通大学 一种基于确定性侧向位移和介电泳技术联用的微藻与细菌分选装置
TWI889038B (zh) * 2023-04-14 2025-07-01 前瞻優勢生醫股份有限公司 微流體微粒分選器
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Also Published As

Publication number Publication date
CN111615552B (zh) 2023-07-11
US20190224677A1 (en) 2019-07-25
US11872560B2 (en) 2024-01-16
US20210114028A1 (en) 2021-04-22
DE112019000463B4 (de) 2024-04-25
JP2021510516A (ja) 2021-04-30
GB202010486D0 (en) 2020-08-19
DE112019000463T5 (de) 2020-10-01
US10946380B2 (en) 2021-03-16
WO2019142087A1 (en) 2019-07-25
CN111615552A (zh) 2020-09-01

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