GB2394658A - Oral anti-cancer composition - Google Patents
Oral anti-cancer composition Download PDFInfo
- Publication number
- GB2394658A GB2394658A GB0225508A GB0225508A GB2394658A GB 2394658 A GB2394658 A GB 2394658A GB 0225508 A GB0225508 A GB 0225508A GB 0225508 A GB0225508 A GB 0225508A GB 2394658 A GB2394658 A GB 2394658A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- dose
- doses
- time interval
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Portable Nailing Machines And Staplers (AREA)
- Control Of Eletrric Generators (AREA)
- Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
- Pyrane Compounds (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0225508A GB2394658A (en) | 2002-11-01 | 2002-11-01 | Oral anti-cancer composition |
| DK03773835T DK1572194T3 (da) | 2002-11-01 | 2003-10-30 | Anti-cancersammensætning indeholdende DMXAA |
| SI200331387T SI1572194T1 (sl) | 2002-11-01 | 2003-10-30 | Sestavek proti raku, ki obsega DMXAA |
| JP2004547801A JP2006508091A (ja) | 2002-11-01 | 2003-10-30 | Dmxaaまたは関連の化合物を含む抗がん性組成物 |
| AU2003282215A AU2003282215A1 (en) | 2002-11-01 | 2003-10-30 | Anti-cancer composition comprising dmxaa or related compound |
| ES03773835T ES2311740T3 (es) | 2002-11-01 | 2003-10-30 | Composicion anticancerosa que comprende el dmxaa. |
| PT03773835T PT1572194E (pt) | 2002-11-01 | 2003-10-30 | Composição anticancerosa compreendendo dmxaa |
| AT03773835T ATE401882T1 (de) | 2002-11-01 | 2003-10-30 | Antikrebszubereitung enthaltend dmxaa |
| EP03773835A EP1572194B1 (en) | 2002-11-01 | 2003-10-30 | Anti-cancer composition comprising dmxaa |
| PCT/GB2003/004688 WO2004039363A1 (en) | 2002-11-01 | 2003-10-30 | Anti-cancer composition comprising dmxaa or related compound |
| DE60322425T DE60322425D1 (de) | 2002-11-01 | 2003-10-30 | Antikrebszubereitung enthaltend dmxaa |
| US11/116,798 US7585893B2 (en) | 2002-11-01 | 2005-04-28 | Anti-cancer composition comprising DMXAA or related compound |
| CY20081100909T CY1108292T1 (el) | 2002-11-01 | 2008-08-25 | Αντικαρκινικο σκευασμα που περιεχει dmxaa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0225508A GB2394658A (en) | 2002-11-01 | 2002-11-01 | Oral anti-cancer composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB0225508D0 GB0225508D0 (en) | 2002-12-11 |
| GB2394658A true GB2394658A (en) | 2004-05-05 |
Family
ID=9947036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0225508A Withdrawn GB2394658A (en) | 2002-11-01 | 2002-11-01 | Oral anti-cancer composition |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7585893B2 (enExample) |
| EP (1) | EP1572194B1 (enExample) |
| JP (1) | JP2006508091A (enExample) |
| AT (1) | ATE401882T1 (enExample) |
| AU (1) | AU2003282215A1 (enExample) |
| CY (1) | CY1108292T1 (enExample) |
| DE (1) | DE60322425D1 (enExample) |
| DK (1) | DK1572194T3 (enExample) |
| ES (1) | ES2311740T3 (enExample) |
| GB (1) | GB2394658A (enExample) |
| PT (1) | PT1572194E (enExample) |
| SI (1) | SI1572194T1 (enExample) |
| WO (1) | WO2004039363A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462642B2 (en) | 2002-03-22 | 2008-12-09 | Cancer Research Technology Limited | Anti-cancer combinations |
| US7510830B2 (en) | 2000-07-28 | 2009-03-31 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
| US7585893B2 (en) | 2002-11-01 | 2009-09-08 | Cancer Research Technology Limited | Anti-cancer composition comprising DMXAA or related compound |
| US7863322B2 (en) | 2001-09-03 | 2011-01-04 | Cancer Research Technology Limited | Anti-cancer combinations |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE324888T1 (de) * | 1999-06-14 | 2006-06-15 | Cancer Rec Tech Ltd | Krebstherapie |
| GB0321999D0 (en) * | 2003-09-19 | 2003-10-22 | Cancer Rec Tech Ltd | Anti-cancer combinations |
| ES3007339T3 (en) * | 2004-12-22 | 2025-03-19 | Merck Serono Sa | Cladribine regimen for treating multiple sclerosis |
| AU2006283371A1 (en) * | 2005-08-26 | 2007-03-01 | Antisoma Research Limited | Combinations comprising DMXAA for the treatment of cancer |
| JP5713377B2 (ja) | 2005-12-28 | 2015-05-07 | ザ スクリプス リサーチ インスティテュート | 薬物標的としての天然アンチセンスおよび非コードrna転写物 |
| EA020805B1 (ru) | 2006-05-24 | 2015-01-30 | Мерк Сероно С.А. | Применение комбинации кладрибина и бета-интерферона для лечения рассеянного склероза |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| CN102239260B (zh) | 2008-10-03 | 2017-04-12 | 库尔纳公司 | 通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病 |
| WO2010045551A1 (en) * | 2008-10-17 | 2010-04-22 | Concert Pharmaceuticals, Inc. | Xanthenone-4-acetic acid derivatives |
| CA2746003C (en) | 2008-12-04 | 2020-03-31 | Opko Curna, Llc | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
| KR101840618B1 (ko) | 2008-12-04 | 2018-03-20 | 큐알엔에이, 인크. | 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료 |
| ES2629630T3 (es) | 2008-12-04 | 2017-08-11 | Curna, Inc. | Tratamiento de enfermedades relacionadas con eritropoyetina (EPO) mediante inhibición del transcrito antisentido natural a EPO |
| ES2560107T3 (es) | 2009-02-12 | 2016-02-17 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF |
| CN102482677B (zh) | 2009-03-16 | 2017-10-17 | 库尔纳公司 | 通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病 |
| CA2755404C (en) | 2009-03-17 | 2020-03-24 | Joseph Collard | Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1 |
| EP2427553A4 (en) | 2009-05-06 | 2012-11-07 | Opko Curna Llc | TREATMENT OF LIPID TRANSPORT AND METABOLISM-RELATED DISEASES BY INHIBITING THE NATURAL ANTISENSE TRANSCRIPT AGAINST A LIPID TRANSPORT AND METABOLIC TREATMENT |
| ES2609655T3 (es) | 2009-05-06 | 2017-04-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP |
| WO2010129861A2 (en) | 2009-05-08 | 2010-11-11 | Curna, Inc. | Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family |
| US8957037B2 (en) | 2009-05-18 | 2015-02-17 | Curna, Inc. | Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor |
| CN102549158B (zh) | 2009-05-22 | 2017-09-26 | 库尔纳公司 | 通过抑制针对转录因子e3(tfe3)的天然反义转录物来治疗tfe3和胰岛素受体底物蛋白2(irs2)相关的疾病 |
| CA2764683A1 (en) | 2009-05-28 | 2010-12-02 | Joseph Collard | Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene |
| CN102695797B (zh) | 2009-06-16 | 2018-05-25 | 库尔纳公司 | 通过抑制针对胶原基因的天然反义转录物来治疗胶原基因相关的疾病 |
| JP6128846B2 (ja) | 2009-06-16 | 2017-05-17 | クルナ・インコーポレーテッド | パラオキソナーゼ(pon1)に対する天然アンチセンス転写物の抑制によるpon1遺伝子関連疾患の治療 |
| WO2010151671A2 (en) | 2009-06-24 | 2010-12-29 | Curna, Inc. | Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2 |
| ES2583691T3 (es) | 2009-06-26 | 2016-09-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con un gen del síndrome de Down mediante la inhibición de una transcripción antisentido natural a un gen del síndrome de Down |
| JP2013500017A (ja) | 2009-07-24 | 2013-01-07 | カッパーアールエヌエー,インコーポレイテッド | サ−チュイン(sirt)への天然アンチセンス転写物の阻止によるサ−チュイン(sirt)関連疾患の治療 |
| EP2462229B1 (en) | 2009-08-05 | 2016-05-11 | CuRNA, Inc. | Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins) |
| CN102625841A (zh) | 2009-08-11 | 2012-08-01 | 欧科库尔纳有限责任公司 | 通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病 |
| CA2771228C (en) | 2009-08-21 | 2020-12-29 | Opko Curna, Llc | Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip |
| KR101892760B1 (ko) | 2009-08-25 | 2018-08-28 | 큐알엔에이, 인크. | IQGAP에 대한 천연 안티센스 전사체의 억제에 의한 GTPase 활성화 단백질을 함유하는 IQ 모티프(IQGAP)와 관련된 질환의 치료 |
| JP6175236B2 (ja) | 2009-09-25 | 2017-08-09 | カッパーアールエヌエー,インコーポレイテッド | フィラグリン(flg)の発現および活性の調整によるflg関連疾患の処置 |
| NO2513310T3 (enExample) | 2009-12-16 | 2018-03-31 | ||
| CA2782375C (en) | 2009-12-23 | 2023-10-31 | Opko Curna, Llc | Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2 |
| NO2516648T3 (enExample) | 2009-12-23 | 2018-04-07 | ||
| KR101853508B1 (ko) | 2009-12-29 | 2018-06-20 | 큐알엔에이, 인크. | 종양 단백질 63 (p63)에 대한 천연 안티센스 전사체의 억제에 의한 p63에 관련된 질환의 치료 |
| KR101838305B1 (ko) | 2009-12-29 | 2018-03-13 | 큐알엔에이, 인크. | NRF1(Nuclear Respiratory Factor 1)에 대한 천연 안티센스 전사체의 억제에 의한 핵 호흡 인자 1 관련된 질환의 치료 |
| CN102791862B (zh) | 2009-12-31 | 2017-04-05 | 库尔纳公司 | 通过抑制胰岛素受体底物2(irs2)和转录因子e3(tfe3)的天然反义转录物而治疗irs2相关疾病 |
| CN102906264B (zh) | 2010-01-04 | 2017-08-04 | 库尔纳公司 | 通过抑制干扰素调节因子8(irf8)的天然反义转录物而治疗irf8相关疾病 |
| JP5963680B2 (ja) | 2010-01-06 | 2016-08-03 | カッパーアールエヌエー,インコーポレイテッド | 膵臓発生遺伝子に対する天然アンチセンス転写物の阻害による膵臓発生遺伝子疾患の治療 |
| CA2786535C (en) | 2010-01-11 | 2019-03-26 | Curna, Inc. | Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg |
| JP5981850B2 (ja) | 2010-01-25 | 2016-08-31 | カッパーアールエヌエー,インコーポレイテッド | RNaseH1に対する天然アンチセンス転写物の阻害によるRNaseH1関連疾患の治療 |
| CN102844435B (zh) | 2010-02-22 | 2017-05-10 | 库尔纳公司 | 通过抑制吡咯啉‑5‑羧酸还原酶1(pycr1)的天然反义转录物而治疗pycr1相关疾病 |
| RU2612884C2 (ru) | 2010-04-02 | 2017-03-13 | Курна, Инк. | Лечение заболеваний, связанных с колониестимулирующим фактором 3 (csf3), путем ингибирования природного антисмыслового транскрипта k csf3 |
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| KR101936011B1 (ko) | 2010-05-03 | 2019-01-07 | 큐알엔에이, 인크. | 시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료 |
| TWI531370B (zh) | 2010-05-14 | 2016-05-01 | 可娜公司 | 藉由抑制par4天然反股轉錄本治療par4相關疾病 |
| US8980858B2 (en) | 2010-05-26 | 2015-03-17 | Curna, Inc. | Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA |
| US8895528B2 (en) | 2010-05-26 | 2014-11-25 | Curna, Inc. | Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1 |
| KR101914309B1 (ko) | 2010-06-23 | 2018-11-02 | 큐알엔에이, 인크. | 전압 작동 나트륨 통로, 알파 소단위(scna)에 대한 자연 안티센스 전사체의 저해에 의한 전압 작동 나트륨 통로, 알파 소단위(scna) 관련된 질환의 치료 |
| JP5998131B2 (ja) | 2010-07-14 | 2016-09-28 | カッパーアールエヌエー,インコーポレイテッド | Discslargehomolog(dlg)dlg1への天然アンチセンス転写物の阻害によるdlg関連疾患の治療 |
| KR101886457B1 (ko) | 2010-10-06 | 2018-08-07 | 큐알엔에이, 인크. | 시알리다아제 4 (neu4)에 대한 자연 안티센스 전사체의 저해에 의한 neu4 관련된 질환의 치료 |
| WO2012054723A2 (en) | 2010-10-22 | 2012-04-26 | Opko Curna Llc | Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua |
| US10000752B2 (en) | 2010-11-18 | 2018-06-19 | Curna, Inc. | Antagonat compositions and methods of use |
| ES2657590T3 (es) | 2010-11-23 | 2018-03-06 | Curna, Inc. | Tratamiento de enfermedades relacionadas con nanog mediante inhibición del transcrito antisentido natural a nanog |
| TWI678375B (zh) | 2011-06-09 | 2019-12-01 | 可娜公司 | 藉由抑制共濟蛋白(frataxin,fxn)之天然反股轉錄本治療fxn相關疾病 |
| CN103874486A (zh) | 2011-09-06 | 2014-06-18 | 库尔纳公司 | 用小分子治疗与电压门控钠通道的α亚基(SCNxA)相关的疾病 |
| EP2825648B1 (en) | 2012-03-15 | 2018-09-05 | CuRNA, Inc. | Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf |
| CN119097635A (zh) | 2017-11-24 | 2024-12-10 | 默克专利股份公司 | 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法 |
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- 2003-10-30 AU AU2003282215A patent/AU2003282215A1/en not_active Abandoned
- 2003-10-30 EP EP03773835A patent/EP1572194B1/en not_active Expired - Lifetime
- 2003-10-30 DK DK03773835T patent/DK1572194T3/da active
- 2003-10-30 PT PT03773835T patent/PT1572194E/pt unknown
- 2003-10-30 ES ES03773835T patent/ES2311740T3/es not_active Expired - Lifetime
- 2003-10-30 WO PCT/GB2003/004688 patent/WO2004039363A1/en not_active Ceased
- 2003-10-30 SI SI200331387T patent/SI1572194T1/sl unknown
- 2003-10-30 JP JP2004547801A patent/JP2006508091A/ja active Pending
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7510830B2 (en) | 2000-07-28 | 2009-03-31 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
| US7863322B2 (en) | 2001-09-03 | 2011-01-04 | Cancer Research Technology Limited | Anti-cancer combinations |
| US7863321B2 (en) | 2001-09-03 | 2011-01-04 | Cancer Research Technology Limited | Anti-cancer combinations |
| US7863320B2 (en) | 2001-09-03 | 2011-01-04 | Cancer Research Technology Limited | Anti-cancer combinations |
| US7868040B2 (en) | 2001-09-03 | 2011-01-11 | Cancer Research Technology Limited | Anti-cancer combinations |
| US7868039B2 (en) | 2001-09-03 | 2011-01-11 | Cancer Research Technology Limited | Anti-cancer combinations |
| US7462642B2 (en) | 2002-03-22 | 2008-12-09 | Cancer Research Technology Limited | Anti-cancer combinations |
| US7585893B2 (en) | 2002-11-01 | 2009-09-08 | Cancer Research Technology Limited | Anti-cancer composition comprising DMXAA or related compound |
Also Published As
| Publication number | Publication date |
|---|---|
| US7585893B2 (en) | 2009-09-08 |
| CY1108292T1 (el) | 2014-02-12 |
| US20060009505A1 (en) | 2006-01-12 |
| SI1572194T1 (sl) | 2008-12-31 |
| ATE401882T1 (de) | 2008-08-15 |
| GB0225508D0 (en) | 2002-12-11 |
| JP2006508091A (ja) | 2006-03-09 |
| AU2003282215A1 (en) | 2004-05-25 |
| DK1572194T3 (da) | 2008-08-25 |
| PT1572194E (pt) | 2008-11-03 |
| DE60322425D1 (de) | 2008-09-04 |
| WO2004039363A1 (en) | 2004-05-13 |
| ES2311740T3 (es) | 2009-02-16 |
| EP1572194B1 (en) | 2008-07-23 |
| EP1572194A1 (en) | 2005-09-14 |
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