GB2394658A - Oral anti-cancer composition - Google Patents

Oral anti-cancer composition Download PDF

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Publication number
GB2394658A
GB2394658A GB0225508A GB0225508A GB2394658A GB 2394658 A GB2394658 A GB 2394658A GB 0225508 A GB0225508 A GB 0225508A GB 0225508 A GB0225508 A GB 0225508A GB 2394658 A GB2394658 A GB 2394658A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
dose
doses
time interval
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0225508A
Other languages
English (en)
Other versions
GB0225508D0 (en
Inventor
Bruce Charles Baguley
Lai-Ming Ching
Philip Kestell
Liangli Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Technology Ltd
Original Assignee
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Technology Ltd filed Critical Cancer Research Technology Ltd
Priority to GB0225508A priority Critical patent/GB2394658A/en
Publication of GB0225508D0 publication Critical patent/GB0225508D0/en
Priority to AT03773835T priority patent/ATE401882T1/de
Priority to PCT/GB2003/004688 priority patent/WO2004039363A1/en
Priority to AU2003282215A priority patent/AU2003282215A1/en
Priority to ES03773835T priority patent/ES2311740T3/es
Priority to PT03773835T priority patent/PT1572194E/pt
Priority to SI200331387T priority patent/SI1572194T1/sl
Priority to EP03773835A priority patent/EP1572194B1/en
Priority to JP2004547801A priority patent/JP2006508091A/ja
Priority to DE60322425T priority patent/DE60322425D1/de
Priority to DK03773835T priority patent/DK1572194T3/da
Publication of GB2394658A publication Critical patent/GB2394658A/en
Priority to US11/116,798 priority patent/US7585893B2/en
Priority to CY20081100909T priority patent/CY1108292T1/el
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Portable Nailing Machines And Staplers (AREA)
  • Control Of Eletrric Generators (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Pyrane Compounds (AREA)
GB0225508A 2002-11-01 2002-11-01 Oral anti-cancer composition Withdrawn GB2394658A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB0225508A GB2394658A (en) 2002-11-01 2002-11-01 Oral anti-cancer composition
DK03773835T DK1572194T3 (da) 2002-11-01 2003-10-30 Anti-cancersammensætning indeholdende DMXAA
SI200331387T SI1572194T1 (sl) 2002-11-01 2003-10-30 Sestavek proti raku, ki obsega DMXAA
JP2004547801A JP2006508091A (ja) 2002-11-01 2003-10-30 Dmxaaまたは関連の化合物を含む抗がん性組成物
AU2003282215A AU2003282215A1 (en) 2002-11-01 2003-10-30 Anti-cancer composition comprising dmxaa or related compound
ES03773835T ES2311740T3 (es) 2002-11-01 2003-10-30 Composicion anticancerosa que comprende el dmxaa.
PT03773835T PT1572194E (pt) 2002-11-01 2003-10-30 Composição anticancerosa compreendendo dmxaa
AT03773835T ATE401882T1 (de) 2002-11-01 2003-10-30 Antikrebszubereitung enthaltend dmxaa
EP03773835A EP1572194B1 (en) 2002-11-01 2003-10-30 Anti-cancer composition comprising dmxaa
PCT/GB2003/004688 WO2004039363A1 (en) 2002-11-01 2003-10-30 Anti-cancer composition comprising dmxaa or related compound
DE60322425T DE60322425D1 (de) 2002-11-01 2003-10-30 Antikrebszubereitung enthaltend dmxaa
US11/116,798 US7585893B2 (en) 2002-11-01 2005-04-28 Anti-cancer composition comprising DMXAA or related compound
CY20081100909T CY1108292T1 (el) 2002-11-01 2008-08-25 Αντικαρκινικο σκευασμα που περιεχει dmxaa

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0225508A GB2394658A (en) 2002-11-01 2002-11-01 Oral anti-cancer composition

Publications (2)

Publication Number Publication Date
GB0225508D0 GB0225508D0 (en) 2002-12-11
GB2394658A true GB2394658A (en) 2004-05-05

Family

ID=9947036

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0225508A Withdrawn GB2394658A (en) 2002-11-01 2002-11-01 Oral anti-cancer composition

Country Status (13)

Country Link
US (1) US7585893B2 (enExample)
EP (1) EP1572194B1 (enExample)
JP (1) JP2006508091A (enExample)
AT (1) ATE401882T1 (enExample)
AU (1) AU2003282215A1 (enExample)
CY (1) CY1108292T1 (enExample)
DE (1) DE60322425D1 (enExample)
DK (1) DK1572194T3 (enExample)
ES (1) ES2311740T3 (enExample)
GB (1) GB2394658A (enExample)
PT (1) PT1572194E (enExample)
SI (1) SI1572194T1 (enExample)
WO (1) WO2004039363A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462642B2 (en) 2002-03-22 2008-12-09 Cancer Research Technology Limited Anti-cancer combinations
US7510830B2 (en) 2000-07-28 2009-03-31 Cancer Research Technology Limited Cancer treatment by combination therapy
US7585893B2 (en) 2002-11-01 2009-09-08 Cancer Research Technology Limited Anti-cancer composition comprising DMXAA or related compound
US7863322B2 (en) 2001-09-03 2011-01-04 Cancer Research Technology Limited Anti-cancer combinations

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE324888T1 (de) * 1999-06-14 2006-06-15 Cancer Rec Tech Ltd Krebstherapie
GB0321999D0 (en) * 2003-09-19 2003-10-22 Cancer Rec Tech Ltd Anti-cancer combinations
ES3007339T3 (en) * 2004-12-22 2025-03-19 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
AU2006283371A1 (en) * 2005-08-26 2007-03-01 Antisoma Research Limited Combinations comprising DMXAA for the treatment of cancer
JP5713377B2 (ja) 2005-12-28 2015-05-07 ザ スクリプス リサーチ インスティテュート 薬物標的としての天然アンチセンスおよび非コードrna転写物
EA020805B1 (ru) 2006-05-24 2015-01-30 Мерк Сероно С.А. Применение комбинации кладрибина и бета-интерферона для лечения рассеянного склероза
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CN102239260B (zh) 2008-10-03 2017-04-12 库尔纳公司 通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病
WO2010045551A1 (en) * 2008-10-17 2010-04-22 Concert Pharmaceuticals, Inc. Xanthenone-4-acetic acid derivatives
CA2746003C (en) 2008-12-04 2020-03-31 Opko Curna, Llc Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
KR101840618B1 (ko) 2008-12-04 2018-03-20 큐알엔에이, 인크. 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
ES2629630T3 (es) 2008-12-04 2017-08-11 Curna, Inc. Tratamiento de enfermedades relacionadas con eritropoyetina (EPO) mediante inhibición del transcrito antisentido natural a EPO
ES2560107T3 (es) 2009-02-12 2016-02-17 Curna, Inc. Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF
CN102482677B (zh) 2009-03-16 2017-10-17 库尔纳公司 通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病
CA2755404C (en) 2009-03-17 2020-03-24 Joseph Collard Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
EP2427553A4 (en) 2009-05-06 2012-11-07 Opko Curna Llc TREATMENT OF LIPID TRANSPORT AND METABOLISM-RELATED DISEASES BY INHIBITING THE NATURAL ANTISENSE TRANSCRIPT AGAINST A LIPID TRANSPORT AND METABOLIC TREATMENT
ES2609655T3 (es) 2009-05-06 2017-04-21 Curna, Inc. Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP
WO2010129861A2 (en) 2009-05-08 2010-11-11 Curna, Inc. Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
US8957037B2 (en) 2009-05-18 2015-02-17 Curna, Inc. Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
CN102549158B (zh) 2009-05-22 2017-09-26 库尔纳公司 通过抑制针对转录因子e3(tfe3)的天然反义转录物来治疗tfe3和胰岛素受体底物蛋白2(irs2)相关的疾病
CA2764683A1 (en) 2009-05-28 2010-12-02 Joseph Collard Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
CN102695797B (zh) 2009-06-16 2018-05-25 库尔纳公司 通过抑制针对胶原基因的天然反义转录物来治疗胶原基因相关的疾病
JP6128846B2 (ja) 2009-06-16 2017-05-17 クルナ・インコーポレーテッド パラオキソナーゼ(pon1)に対する天然アンチセンス転写物の抑制によるpon1遺伝子関連疾患の治療
WO2010151671A2 (en) 2009-06-24 2010-12-29 Curna, Inc. Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
ES2583691T3 (es) 2009-06-26 2016-09-21 Curna, Inc. Tratamiento de enfermedades relacionadas con un gen del síndrome de Down mediante la inhibición de una transcripción antisentido natural a un gen del síndrome de Down
JP2013500017A (ja) 2009-07-24 2013-01-07 カッパーアールエヌエー,インコーポレイテッド サ−チュイン(sirt)への天然アンチセンス転写物の阻止によるサ−チュイン(sirt)関連疾患の治療
EP2462229B1 (en) 2009-08-05 2016-05-11 CuRNA, Inc. Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
CN102625841A (zh) 2009-08-11 2012-08-01 欧科库尔纳有限责任公司 通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病
CA2771228C (en) 2009-08-21 2020-12-29 Opko Curna, Llc Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip
KR101892760B1 (ko) 2009-08-25 2018-08-28 큐알엔에이, 인크. IQGAP에 대한 천연 안티센스 전사체의 억제에 의한 GTPase 활성화 단백질을 함유하는 IQ 모티프(IQGAP)와 관련된 질환의 치료
JP6175236B2 (ja) 2009-09-25 2017-08-09 カッパーアールエヌエー,インコーポレイテッド フィラグリン(flg)の発現および活性の調整によるflg関連疾患の処置
NO2513310T3 (enExample) 2009-12-16 2018-03-31
CA2782375C (en) 2009-12-23 2023-10-31 Opko Curna, Llc Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
NO2516648T3 (enExample) 2009-12-23 2018-04-07
KR101853508B1 (ko) 2009-12-29 2018-06-20 큐알엔에이, 인크. 종양 단백질 63 (p63)에 대한 천연 안티센스 전사체의 억제에 의한 p63에 관련된 질환의 치료
KR101838305B1 (ko) 2009-12-29 2018-03-13 큐알엔에이, 인크. NRF1(Nuclear Respiratory Factor 1)에 대한 천연 안티센스 전사체의 억제에 의한 핵 호흡 인자 1 관련된 질환의 치료
CN102791862B (zh) 2009-12-31 2017-04-05 库尔纳公司 通过抑制胰岛素受体底物2(irs2)和转录因子e3(tfe3)的天然反义转录物而治疗irs2相关疾病
CN102906264B (zh) 2010-01-04 2017-08-04 库尔纳公司 通过抑制干扰素调节因子8(irf8)的天然反义转录物而治疗irf8相关疾病
JP5963680B2 (ja) 2010-01-06 2016-08-03 カッパーアールエヌエー,インコーポレイテッド 膵臓発生遺伝子に対する天然アンチセンス転写物の阻害による膵臓発生遺伝子疾患の治療
CA2786535C (en) 2010-01-11 2019-03-26 Curna, Inc. Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
JP5981850B2 (ja) 2010-01-25 2016-08-31 カッパーアールエヌエー,インコーポレイテッド RNaseH1に対する天然アンチセンス転写物の阻害によるRNaseH1関連疾患の治療
CN102844435B (zh) 2010-02-22 2017-05-10 库尔纳公司 通过抑制吡咯啉‑5‑羧酸还原酶1(pycr1)的天然反义转录物而治疗pycr1相关疾病
RU2612884C2 (ru) 2010-04-02 2017-03-13 Курна, Инк. Лечение заболеваний, связанных с колониестимулирующим фактором 3 (csf3), путем ингибирования природного антисмыслового транскрипта k csf3
CN102858979B (zh) 2010-04-09 2018-01-26 库尔纳公司 通过抑制成纤维细胞生长因子21(fgf21)的天然反义转录物而治疗fgf21相关疾病
KR101936011B1 (ko) 2010-05-03 2019-01-07 큐알엔에이, 인크. 시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료
TWI531370B (zh) 2010-05-14 2016-05-01 可娜公司 藉由抑制par4天然反股轉錄本治療par4相關疾病
US8980858B2 (en) 2010-05-26 2015-03-17 Curna, Inc. Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA
US8895528B2 (en) 2010-05-26 2014-11-25 Curna, Inc. Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
KR101914309B1 (ko) 2010-06-23 2018-11-02 큐알엔에이, 인크. 전압 작동 나트륨 통로, 알파 소단위(scna)에 대한 자연 안티센스 전사체의 저해에 의한 전압 작동 나트륨 통로, 알파 소단위(scna) 관련된 질환의 치료
JP5998131B2 (ja) 2010-07-14 2016-09-28 カッパーアールエヌエー,インコーポレイテッド Discslargehomolog(dlg)dlg1への天然アンチセンス転写物の阻害によるdlg関連疾患の治療
KR101886457B1 (ko) 2010-10-06 2018-08-07 큐알엔에이, 인크. 시알리다아제 4 (neu4)에 대한 자연 안티센스 전사체의 저해에 의한 neu4 관련된 질환의 치료
WO2012054723A2 (en) 2010-10-22 2012-04-26 Opko Curna Llc Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
US10000752B2 (en) 2010-11-18 2018-06-19 Curna, Inc. Antagonat compositions and methods of use
ES2657590T3 (es) 2010-11-23 2018-03-06 Curna, Inc. Tratamiento de enfermedades relacionadas con nanog mediante inhibición del transcrito antisentido natural a nanog
TWI678375B (zh) 2011-06-09 2019-12-01 可娜公司 藉由抑制共濟蛋白(frataxin,fxn)之天然反股轉錄本治療fxn相關疾病
CN103874486A (zh) 2011-09-06 2014-06-18 库尔纳公司 用小分子治疗与电压门控钠通道的α亚基(SCNxA)相关的疾病
EP2825648B1 (en) 2012-03-15 2018-09-05 CuRNA, Inc. Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
CN119097635A (zh) 2017-11-24 2024-12-10 默克专利股份公司 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法
EP4241790A1 (en) 2022-03-07 2023-09-13 InnaTher Gene Therapy S.à.r.l. Expression system for the treatment of cancer
EP4241791A1 (en) 2022-03-07 2023-09-13 InnaTher Gene Therapy S.à.r.l. Combined gene and radio therapy for the treatment of cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278176A2 (en) * 1986-12-23 1988-08-17 Warner-Lambert Company Compounds having antitumour and antibacterial properties

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655470A (en) 1969-03-29 1972-04-11 Toa Gosei Chem Ind Process for the production of a foamed thermoplastic resin sheet
DE2015265A1 (de) 1969-03-29 1970-10-08 Yoshitomi Pharmaceutical Industries Ltd., Osaka (Japan) Arylalkansäuren und Verfahren zu deren Herstellung
FR2516922A1 (fr) 1981-11-25 1983-05-27 Lipha Acides (oxo-4-4h-(1)-benzopyran-8-yl) alcanoiques, sels et derives, preparation et medicament les contenant
DE3587500T2 (de) 1984-12-04 1993-12-16 Lilly Co Eli Tumorbehandlung bei Säugetieren.
US4704355A (en) 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
US5281620A (en) 1986-12-23 1994-01-25 Cancer Research Campaign Technology Limited Compounds having antitumor and antibacterial properties
JPH01193227A (ja) 1988-01-29 1989-08-03 Res Dev Corp Of Japan 癌免疫療法補助剤
US5126129A (en) * 1988-05-23 1992-06-30 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Cancer therapy using interleukin-2 and flavone compounds
US5075287A (en) 1989-03-03 1991-12-24 Nisshin Oil Mills, Inc. Muramyl peptide derivatives and immunoregulating compositions containing them
CA2025907A1 (en) 1989-09-21 1991-03-22 Franklin D. Collins Method of transporting compositions across the blood brain barrier
US5250296A (en) 1990-11-29 1993-10-05 Takeda Chemical Industries, Ltd. Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine
EP0551200A1 (en) 1992-01-07 1993-07-14 National University Of Singapore Protein phosphatase inhibitors for use in therapy
CA2086874E (en) 1992-08-03 2000-01-04 Renzo Mauro Canetta Methods for administration of taxol
GB9308166D0 (en) 1993-04-20 1993-06-02 Cancer Res Campaign Tech Cancer therapy
GB9320484D0 (en) 1993-10-05 1993-11-24 Wellcome Found Pharmaceutical combinations
US5620875A (en) 1995-02-17 1997-04-15 University Of Portland Transfer of taxol from yew tree cuttings into a culture medium over time
AU5688596A (en) 1995-04-13 1996-10-30 Deutsche Om Arzneimittel Gmbh Anti-cd14 antibodies for use in the induction of il-10 secre tion
WO1996036347A1 (en) 1995-05-17 1996-11-21 Eli Lilly And Company Use of leukotriene antagonists for alzheimer's disease
JPH0940690A (ja) 1995-05-23 1997-02-10 Yutaka Sashita ステロイド配糖体及びこれを有効成分とする医薬
AU6714396A (en) 1995-07-28 1997-02-26 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
US5977077A (en) 1995-08-28 1999-11-02 Interlab Corporation Xanthone analogs for the treatment of infectious diseases
US5863904A (en) 1995-09-26 1999-01-26 The University Of Michigan Methods for treating cancers and restenosis with P21
UA47505C2 (uk) 1996-12-13 2002-07-15 Елі Ліллі Енд Компані Спосіб лікування плоскоклітинного раку ротової порожнини за допомогою антагоністів лейкотриєну
EP0961617A4 (en) 1996-12-13 2002-08-07 Lilly Co Eli LEUKOTRINE ANTAGONISTS FOR TREATING FOCAL BRAIN CHEMISTRY
WO1998025600A1 (en) 1996-12-13 1998-06-18 Eli Lilly And Company Leukotriene antagonists for treatment or inhibition of gout
AU6450898A (en) 1997-03-21 1998-10-20 Eli Lilly And Company Leukotriene antagonists useful for treating cerebral focal stroke
US5914340A (en) 1997-03-21 1999-06-22 Eli Lilly And Company Leukotriene antagonists useful for treating dermatoses
US5998454A (en) 1997-03-21 1999-12-07 Eli Lilly And Company Leukotriene antagonists useful for treating iritis
AU6572298A (en) 1997-03-21 1998-10-20 Eli Lilly And Company Leukotriene antagonists useful for treating ischemia reperfusion injury
AU6764798A (en) 1997-03-21 1998-10-20 Eli Lilly And Company Leukotriene antagonists useful for treating cystic fibrosis
HUP9904672A2 (hu) 1997-03-21 2000-05-28 Eli Lilly And Co. Szájüregi laphámrák ellen alkalmazható leukotrién antagonisták
AU6450498A (en) 1997-03-21 1998-10-20 Eli Lilly And Company Leukotriene antagonists useful for treating gout
WO1998042336A1 (en) 1997-03-21 1998-10-01 Eli Lilly And Company Leukotriene antagonists useful for treating gingivitis
DE19721211A1 (de) 1997-05-21 1998-11-26 Lindner Sen Wolfgang Dr Med Kombination von antientzündlichen Wirkstoffen mit immunstimulierenden Agentien und zytotoxischen Agentien zur Behandlung von Tumoren
CN1217698C (zh) 1998-08-24 2005-09-07 马克西姆药品公司 应用h2受体激动剂和其它t细胞活化剂激活和保护t细胞(cd4+和cd8+)
AUPP609198A0 (en) 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
US6174873B1 (en) * 1998-11-04 2001-01-16 Supergen, Inc. Oral administration of adenosine analogs
GB9903404D0 (en) 1999-02-16 1999-04-07 Angiogene Pharm Ltd Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis
PT1033364E (pt) * 1999-03-01 2005-07-29 Pfizer Prod Inc Ciano com acidos oxamicos e derivados como ligandos de receptores de tiroide
ATE324888T1 (de) 1999-06-14 2006-06-15 Cancer Rec Tech Ltd Krebstherapie
US6806257B1 (en) 1999-10-20 2004-10-19 Board Of Trustees Of Southern Illinois University Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators
AU1916501A (en) 1999-11-11 2001-06-06 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
TR200201245T2 (tr) 1999-11-11 2004-08-23 Eli Lilly And Company Kanser tedavisi için onkolitik kombinasyonlar.
JP2003513914A (ja) 1999-11-11 2003-04-15 イーライ・リリー・アンド・カンパニー 癌の処置のための腫瘍崩壊薬の組み合わせ
AU1916601A (en) 1999-11-11 2001-06-06 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
WO2001060365A1 (en) 2000-02-17 2001-08-23 Merck & Co., Inc. Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
JP2001247459A (ja) 2000-03-03 2001-09-11 Oakland Uniservices Ltd 癌の組み合わせ療法
JP2004505047A (ja) 2000-07-28 2004-02-19 キャンサー・リサーチ・テクノロジー・リミテッド 複合治療による癌治療
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
GB2386836B (en) 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
GB2394658A (en) 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
GB0321999D0 (en) 2003-09-19 2003-10-22 Cancer Rec Tech Ltd Anti-cancer combinations
AU2006283371A1 (en) 2005-08-26 2007-03-01 Antisoma Research Limited Combinations comprising DMXAA for the treatment of cancer
GB0517387D0 (en) 2005-08-26 2005-10-05 Antisoma Res Ltd Combinations for the treatment of cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278176A2 (en) * 1986-12-23 1988-08-17 Warner-Lambert Company Compounds having antitumour and antibacterial properties

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
cANCER cHEMOTHER. pHARMACOL., 49, 20-6, (2002) *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7510830B2 (en) 2000-07-28 2009-03-31 Cancer Research Technology Limited Cancer treatment by combination therapy
US7863322B2 (en) 2001-09-03 2011-01-04 Cancer Research Technology Limited Anti-cancer combinations
US7863321B2 (en) 2001-09-03 2011-01-04 Cancer Research Technology Limited Anti-cancer combinations
US7863320B2 (en) 2001-09-03 2011-01-04 Cancer Research Technology Limited Anti-cancer combinations
US7868040B2 (en) 2001-09-03 2011-01-11 Cancer Research Technology Limited Anti-cancer combinations
US7868039B2 (en) 2001-09-03 2011-01-11 Cancer Research Technology Limited Anti-cancer combinations
US7462642B2 (en) 2002-03-22 2008-12-09 Cancer Research Technology Limited Anti-cancer combinations
US7585893B2 (en) 2002-11-01 2009-09-08 Cancer Research Technology Limited Anti-cancer composition comprising DMXAA or related compound

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ATE401882T1 (de) 2008-08-15
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AU2003282215A1 (en) 2004-05-25
DK1572194T3 (da) 2008-08-25
PT1572194E (pt) 2008-11-03
DE60322425D1 (de) 2008-09-04
WO2004039363A1 (en) 2004-05-13
ES2311740T3 (es) 2009-02-16
EP1572194B1 (en) 2008-07-23
EP1572194A1 (en) 2005-09-14

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