GB2392397B - Cascaded hydrodynamic focusing in microfluidic channels - Google Patents

Cascaded hydrodynamic focusing in microfluidic channels

Info

Publication number
GB2392397B
GB2392397B GB0310257A GB0310257A GB2392397B GB 2392397 B GB2392397 B GB 2392397B GB 0310257 A GB0310257 A GB 0310257A GB 0310257 A GB0310257 A GB 0310257A GB 2392397 B GB2392397 B GB 2392397B
Authority
GB
United Kingdom
Prior art keywords
cascaded
microfluidic channels
hydrodynamic focusing
hydrodynamic
focusing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0310257A
Other languages
English (en)
Other versions
GB0310257D0 (en
GB2392397A (en
Inventor
Horst Haussecker
Narayan Sundararajan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intel Corp
Original Assignee
Intel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intel Corp filed Critical Intel Corp
Publication of GB0310257D0 publication Critical patent/GB0310257D0/en
Publication of GB2392397A publication Critical patent/GB2392397A/en
Application granted granted Critical
Publication of GB2392397B publication Critical patent/GB2392397B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B7/00—Microstructural systems ; Auxiliary parts of microstructural devices or systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
GB0310257A 2002-08-30 2003-05-06 Cascaded hydrodynamic focusing in microfluidic channels Expired - Fee Related GB2392397B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/232,170 US20040043506A1 (en) 2002-08-30 2002-08-30 Cascaded hydrodynamic focusing in microfluidic channels

Publications (3)

Publication Number Publication Date
GB0310257D0 GB0310257D0 (en) 2003-06-11
GB2392397A GB2392397A (en) 2004-03-03
GB2392397B true GB2392397B (en) 2005-01-19

Family

ID=22872139

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0310257A Expired - Fee Related GB2392397B (en) 2002-08-30 2003-05-06 Cascaded hydrodynamic focusing in microfluidic channels

Country Status (8)

Country Link
US (1) US20040043506A1 (https=)
JP (1) JP2004093553A (https=)
KR (1) KR100508326B1 (https=)
CN (1) CN1482369A (https=)
DE (1) DE10334341A1 (https=)
GB (1) GB2392397B (https=)
NL (1) NL1024013C2 (https=)
TW (1) TW200412482A (https=)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US7242474B2 (en) * 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
US20090065471A1 (en) * 2003-02-10 2009-03-12 Faris Sadeg M Micro-nozzle, nano-nozzle, manufacturing methods therefor, applications therefor
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
EP2359689B1 (en) * 2002-09-27 2015-08-26 The General Hospital Corporation Microfluidic device for cell separation and use thereof
EP1636564A1 (en) * 2003-06-13 2006-03-22 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
US7311476B2 (en) 2003-10-30 2007-12-25 Cytonome, Inc. Multilayer hydrodynamic sheath flow structure
US20050266433A1 (en) * 2004-03-03 2005-12-01 Ravi Kapur Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US7438792B2 (en) * 2004-04-20 2008-10-21 The Regents Of The University Of California Separation system with a sheath-flow supported electrochemical detector
WO2006061025A2 (en) * 2004-12-09 2006-06-15 Inverness Medical Switzerland Gmbh A method of producing a micro fluidic device and a micro fluidic device
EP1843849A2 (en) * 2005-01-12 2007-10-17 Inverness Medical Switzerland GmbH A method of producing a microfluidic device and microfluidic devices
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20090181421A1 (en) * 2005-07-29 2009-07-16 Ravi Kapur Diagnosis of fetal abnormalities using nucleated red blood cells
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2029779A4 (en) * 2006-06-14 2010-01-20 Living Microsystems Inc HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
KR101419312B1 (ko) 2006-09-01 2014-07-14 도소 가부시키가이샤 미소유로 구조 및 그것을 사용한 미소입자 제조 방법
KR101556798B1 (ko) 2006-10-05 2015-10-01 메사츄세츠 인스티튜트 어브 테크놀로지 고성능 분석을 위한 다중기능성 인코딩된 입자
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
EP2101917A1 (en) * 2007-01-10 2009-09-23 Scandinavian Micro Biodevices A/S A microfluidic device and a microfluidic system and a method of performing a test
CN102124259B (zh) 2008-05-16 2015-12-16 哈佛大学 在包含微流体系统的流体系统中的阀和其它流动控制
WO2009152618A1 (en) * 2008-06-17 2009-12-23 The Governing Council Of The University Of Toronto Device for investigation of a flow conduit
US20090318303A1 (en) * 2008-06-20 2009-12-24 International Business Machines Corporation Microfluidic selection of library elements
CA3069082C (en) 2008-09-20 2022-03-22 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
CN104155210B (zh) 2008-10-02 2017-08-22 彼克斯赛尔医疗科技有限公司 基于粘弹性聚焦的光学成像
PL2440941T3 (pl) * 2009-06-10 2017-10-31 Cynvenio Biosystems Inc Sposoby i urządzenia z przepływem laminarnym
US8034629B2 (en) * 2009-06-26 2011-10-11 Massachusetts Institute Of Technology High precision scanning of encoded hydrogel microparticles
KR101932628B1 (ko) 2010-06-07 2018-12-27 파이어플라이 바이오웍스, 인코포레이티드 후­혼성 표지화 및 범용 코드화에 의한 핵산 검출 및 정량화
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
WO2014142924A1 (en) * 2013-03-14 2014-09-18 Inguran, Llc Apparatus and methods for high throughput sperm sorting
NZ743491A (en) 2013-03-14 2020-03-27 Cytonome St Llc Hydrodynamic focusing apparatus and methods
US9757726B2 (en) 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
US10371622B2 (en) 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US10662408B2 (en) 2013-03-14 2020-05-26 Inguran, Llc Methods for high throughput sperm sorting
US11493428B2 (en) 2013-03-15 2022-11-08 Gpb Scientific, Inc. On-chip microfluidic processing of particles
EP3608022A1 (en) 2013-03-15 2020-02-12 The Trustees of Princeton University Methods and devices for high throughput purification
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
US12590955B2 (en) 2013-03-15 2026-03-31 Zeon Corporation Methods and systems for processing particles
CN103240023B (zh) * 2013-05-09 2015-01-07 四川大学 一种微手术刀触发液滴融合的方法
JP6205055B2 (ja) * 2013-07-16 2017-09-27 プレミアム ジェネティクス （ユーケー） リミテッド マイクロ流体チップ
US8961904B2 (en) * 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
JP6733909B2 (ja) * 2013-10-30 2020-08-05 エービーエス グローバル インコーポレイテッド 複数の物質を識別する装置、複数の物質を識別するコンピュータシステム、複数の物質を識別するための複数の命令をコンピュータに実行させるプログラムおよびサンプル流体混合物中を流れる複数の物質を識別する方法
EP3074122A4 (en) * 2013-11-27 2017-11-29 Bio-Rad Laboratories, Inc. Microfluidic droplet packing
CA2936771A1 (fr) * 2014-01-14 2015-07-23 Centre National De La Recherche Scientifique (Cnrs) Dispositif microfluidique pour l'analyse de polluants en ecoulement
WO2015116990A1 (en) * 2014-01-30 2015-08-06 The General Hospital Corporation Inertio-elastic focusing of particles in microchannels
CN103848394A (zh) * 2014-02-21 2014-06-11 上海大学 基于微流体芯片的多种纳米线阵列水力聚焦组装方法
US10180388B2 (en) 2015-02-19 2019-01-15 1087 Systems, Inc. Scanning infrared measurement system
CN105149019B (zh) * 2015-06-29 2017-04-19 清华大学 用于二维流体动力聚焦的微流道结构和微流体芯片
CA2996529A1 (en) * 2015-08-24 2017-03-02 Gpb Scientific, Llc Methods and devices for multi-step cell purification and concentration
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
US9366606B1 (en) 2015-08-27 2016-06-14 Ativa Medical Corporation Fluid processing micro-feature devices and methods
US20170059459A1 (en) * 2015-08-27 2017-03-02 Ativa Medical Corporation Fluid processing micro-feature devices and methods
US11071982B2 (en) 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US20170059590A1 (en) 2015-08-27 2017-03-02 Ativa Medical Corporation Fluid holding and dispensing micro-feature
DE102015115343B4 (de) * 2015-09-11 2017-10-26 Leibniz-Institut für Photonische Technologien e. V. Anordnung und Verfahren für die Fluidrotation
WO2017041782A1 (de) 2015-09-11 2017-03-16 Leibniz-Institut Für Photonische Technologien E.V. Anordnung für die individualisierte patientenblutanalyse
GB201516447D0 (en) 2015-09-16 2015-10-28 Sphere Fluidics Ltd Microfluidic structure
US10913039B2 (en) 2016-07-06 2021-02-09 Hewlett-Packard Development Company, L.P. Microfluidic mixer
US11067494B2 (en) * 2016-09-15 2021-07-20 Indian Institute Of Science Multidimensional microfluid focusing device
CN107376796B (zh) * 2017-07-10 2019-09-17 于志远 一种微反应器的加工方法及微反应器
CN111065399B (zh) 2017-09-01 2023-11-28 Gpb科学有限公司 使用微流体制备治疗活性细胞的方法
GB201720627D0 (en) * 2017-12-11 2018-01-24 Cambridge Entpr Ltd Fluidic apparatus and methods
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
CN108896470B (zh) * 2018-07-31 2021-03-16 电子科技大学 基于led阵列的微流通道旋转细胞相衬成像方法及系统
CN108896471B (zh) * 2018-07-31 2021-03-16 电子科技大学 基于led阵列微流通道活细胞相衬成像方法及系统
EP3899489B1 (en) 2018-12-21 2025-04-09 ABS Global, Inc. System and methods for sub-population identification
EP3955735B1 (en) 2019-04-18 2024-05-22 ABS Global, Inc. System and process for continuous addition of cryoprotectant
EP3771899A1 (en) 2019-07-30 2021-02-03 Diatron MI PLC Flow cytometer
CN110787846B (zh) * 2019-11-05 2021-04-16 华中科技大学 一种一步式双层微液滴生成装置及方法
CN112973811B (zh) * 2019-12-17 2022-10-18 香港城市大学深圳研究院 一种基于层流扩散的血液中外泌体富集微流控芯片
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
FR3108860B1 (fr) * 2020-04-07 2023-04-21 Centre Nat Rech Scient Microreacteurs en saphir
KR102134655B1 (ko) * 2020-04-23 2020-07-16 농업회사법인 상상텃밭 주식회사 용존산소량 및 양액 농도 조절이 가능한 양액 재배 장치 및 방법
WO2022087299A1 (en) 2020-10-21 2022-04-28 Abs Global, Inc. Methods and systems for processing genetic samples to determine identity or detect contamination
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
CN113134331B (zh) * 2021-05-08 2021-10-26 南开大学 反应器、快检尾气二次气溶胶生成因子的系统及方法
USD1118965S1 (en) 2021-11-12 2026-03-17 Abs Global, Inc. Flow cytometry device
US20250128256A1 (en) * 2022-01-25 2025-04-24 President And Fellows Of Harvard College Microfluidic devices with autonomous directional valves
CN114645986B (zh) * 2022-03-30 2024-04-26 深圳麦科田生物医疗技术股份有限公司 一种同轴流体液路结构

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000070080A1 (en) * 1999-05-17 2000-11-23 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6159739A (en) * 1997-03-26 2000-12-12 University Of Washington Device and method for 3-dimensional alignment of particles in microfabricated flow channels
US6540895B1 (en) * 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000070080A1 (en) * 1999-05-17 2000-11-23 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems

Also Published As

Publication number Publication date
DE10334341A1 (de) 2004-03-18
NL1024013A1 (nl) 2004-03-02
HK1060323A1 (en) 2004-08-06
GB0310257D0 (en) 2003-06-11
KR20040019869A (ko) 2004-03-06
GB2392397A (en) 2004-03-03
JP2004093553A (ja) 2004-03-25
NL1024013C2 (nl) 2005-07-19
US20040043506A1 (en) 2004-03-04
CN1482369A (zh) 2004-03-17
KR100508326B1 (ko) 2005-08-17
TW200412482A (en) 2004-07-16

Similar Documents

Publication Publication Date Title
GB2392397B (en) Cascaded hydrodynamic focusing in microfluidic channels
AU2003277853A8 (en) Recirculating fluidic network and methods for using the same
GB2390774B (en) Identifying bleedthrough in imager
AU2003284055A1 (en) Microfluidic systems and components
AU2002353107A8 (en) Microfluidic devices and methods for two-dimensional separations
AU2003249350A8 (en) Electrochemiluminescence flow cell and flow cell components
AU2002360564A8 (en) Slide case with removable rack
EP1775617A4 (en) AUTOMATIC FOCUSING DEVICE AND MICROSCOPE COMPRISING SAID DEVICE
EP1828640A4 (en) MECHANICAL SYSTEM FOR ALTERING POWER BETWEEN INPUT AND OUTPUT
GB0321918D0 (en) Focusing system and method
EG23602A (en) Reative separation
GB0421143D0 (en) Microfluidic device
GB2401954B (en) Contact lens with channels and holes
HK1060323B (en) Cascaded hydrodynamic focusing in microfluidic channels
GB0020487D0 (en) Moving liquid into and along micro-fluidic channels
GB0327446D0 (en) Biochemical vessel
IL165551A0 (en) Chromophores and methods utilizing the same
GB0126156D0 (en) Assessing channels in communications systems
GB2443335B (en) Graft materials
AU2003219178A8 (en) Hydrodynamic power-generating method
GB0114034D0 (en) Cascaded asymmetric power converter
AU2002327177A1 (en) Microfluidic fraction collectors
GB0218105D0 (en) Improvements in fluid management
AU2001297646A1 (en) Uni-directional flow microfluidic components
BR8101157Y1 (pt) disposiÇço construtiva introduzida no equpamento multifuncional de ensino e pesquisa.

Legal Events

Date Code Title Description
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1060323

Country of ref document: HK

REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1060323

Country of ref document: HK

PCNP Patent ceased through non-payment of renewal fee

Effective date: 20070506