GB2240922A - Bacterial lysate for the treatment of dermatitis - Google Patents
Bacterial lysate for the treatment of dermatitis Download PDFInfo
- Publication number
- GB2240922A GB2240922A GB9103278A GB9103278A GB2240922A GB 2240922 A GB2240922 A GB 2240922A GB 9103278 A GB9103278 A GB 9103278A GB 9103278 A GB9103278 A GB 9103278A GB 2240922 A GB2240922 A GB 2240922A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nctc
- bacterial lysate
- drug
- bacterial
- strains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000001580 bacterial effect Effects 0.000 title claims abstract description 22
- 239000006166 lysate Substances 0.000 title claims abstract description 21
- 238000011282 treatment Methods 0.000 title description 7
- 201000004624 Dermatitis Diseases 0.000 title description 4
- 239000003814 drug Substances 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 20
- 206010012438 Dermatitis atopic Diseases 0.000 claims abstract description 12
- 201000008937 atopic dermatitis Diseases 0.000 claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 241000191967 Staphylococcus aureus Species 0.000 claims abstract description 5
- 241000193998 Streptococcus pneumoniae Species 0.000 claims abstract description 5
- 241000606768 Haemophilus influenzae Species 0.000 claims abstract description 4
- 241000588747 Klebsiella pneumoniae Species 0.000 claims abstract description 4
- 241001312524 Streptococcus viridans Species 0.000 claims abstract description 4
- 241000588655 Moraxella catarrhalis Species 0.000 claims abstract description 3
- 229940047650 haemophilus influenzae Drugs 0.000 claims abstract description 3
- 239000002775 capsule Substances 0.000 claims description 9
- 241000193996 Streptococcus pyogenes Species 0.000 claims description 4
- 241000237519 Bivalvia Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 235000020639 clam Nutrition 0.000 claims 1
- 241000588744 Klebsiella pneumoniae subsp. ozaenae Species 0.000 abstract description 4
- 241000588653 Neisseria Species 0.000 abstract description 4
- 210000002966 serum Anatomy 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010057190 Respiratory tract infections Diseases 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000007813 immunodeficiency Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 239000004251 Ammonium lactate Substances 0.000 description 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010051837 Skin induration Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 229940059265 ammonium lactate Drugs 0.000 description 1
- 235000019286 ammonium lactate Nutrition 0.000 description 1
- 210000001557 animal structure Anatomy 0.000 description 1
- RZOBLYBZQXQGFY-HSHFZTNMSA-N azanium;(2r)-2-hydroxypropanoate Chemical compound [NH4+].C[C@@H](O)C([O-])=O RZOBLYBZQXQGFY-HSHFZTNMSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000011118 depth filtration Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH497/90A CH680045A5 (enrdf_load_stackoverflow) | 1990-02-16 | 1990-02-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB9103278D0 GB9103278D0 (en) | 1991-04-03 |
| GB2240922A true GB2240922A (en) | 1991-08-21 |
Family
ID=4188357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9103278A Withdrawn GB2240922A (en) | 1990-02-16 | 1991-02-15 | Bacterial lysate for the treatment of dermatitis |
Country Status (13)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998013052A1 (fr) * | 1996-09-26 | 1998-04-02 | Chuchalin Alexandr Grigorievic | Produit anti-allergique et anti-inflammatoire, procede de production de ce produit, produit cosmetique et produit hygienique |
| EP2345421A1 (en) | 2003-06-23 | 2011-07-20 | Biotech Tools S.A. | Epitope composition for sublingual or enteric administration prepared by hydrolysis of antigenic structures with chymotrypsin |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999048510A1 (fr) * | 1998-03-24 | 1999-09-30 | Tayca Corporation | Inhibiteur de la production d'anticorps d'immunoglobuline m et medicament contre la polyarthrite rhumatoide |
| UA72065C2 (en) * | 2004-09-10 | 2005-01-17 | Viridans Ltd Liability Company | Strain aerococcus viridans 167k imb b-7069 with antibacterial activity and "viabac" preparation comprising this strain |
| FR2969657B1 (fr) * | 2010-12-22 | 2014-02-07 | Fabre Pierre Dermo Cosmetique | Nouvelle bacterie et extraits de ladite bacterie et leur utilisation en dermatologie |
| GB201318170D0 (en) * | 2013-10-14 | 2013-11-27 | Univ Edinburgh | Proteins with Diagnostic and Therapeutic Uses |
| WO2020218868A1 (ko) * | 2019-04-26 | 2020-10-29 | 주식회사 엠디헬스케어 | 스트렙토코커스 파이오제네스 세균 유래 단백질 및 이의 용도 |
| KR102437436B1 (ko) | 2019-04-26 | 2022-08-30 | 주식회사 엠디헬스케어 | 스트렙토코커스 파이오제네스 세균 유래 단백질 및 이의 용도 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH633188A5 (fr) * | 1978-05-26 | 1982-11-30 | Om Laboratoires Sa | Medicament contre des maladies infectieuses des voies respiratoires. |
-
1990
- 1990-02-16 CH CH497/90A patent/CH680045A5/fr not_active IP Right Cessation
-
1991
- 1991-02-13 KR KR1019910002437A patent/KR0169982B1/ko not_active Expired - Fee Related
- 1991-02-14 IT ITMI910381A patent/IT1244743B/it active IP Right Grant
- 1991-02-14 EG EG9191A patent/EG19540A/xx active
- 1991-02-15 DE DE4104728A patent/DE4104728C2/de not_active Expired - Fee Related
- 1991-02-15 BE BE9100144A patent/BE1005589A3/fr active
- 1991-02-15 JP JP3022109A patent/JP3002552B2/ja not_active Expired - Lifetime
- 1991-02-15 PT PT96789A patent/PT96789B/pt not_active IP Right Cessation
- 1991-02-15 PL PL28908491A patent/PL289084A1/xx unknown
- 1991-02-15 HU HU91511A patent/HU210834B/hu not_active IP Right Cessation
- 1991-02-15 GB GB9103278A patent/GB2240922A/en not_active Withdrawn
- 1991-02-15 FR FR9102058A patent/FR2658419B1/fr not_active Expired - Fee Related
- 1991-02-15 AT AT0032291A patent/AT402152B/de not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998013052A1 (fr) * | 1996-09-26 | 1998-04-02 | Chuchalin Alexandr Grigorievic | Produit anti-allergique et anti-inflammatoire, procede de production de ce produit, produit cosmetique et produit hygienique |
| EP2345421A1 (en) | 2003-06-23 | 2011-07-20 | Biotech Tools S.A. | Epitope composition for sublingual or enteric administration prepared by hydrolysis of antigenic structures with chymotrypsin |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2658419B1 (fr) | 1995-01-27 |
| JPH04211017A (ja) | 1992-08-03 |
| DE4104728C2 (de) | 1999-01-14 |
| CH680045A5 (enrdf_load_stackoverflow) | 1992-06-15 |
| AT402152B (de) | 1997-02-25 |
| PT96789B (pt) | 1998-08-31 |
| HU910511D0 (en) | 1991-09-30 |
| BE1005589A3 (fr) | 1993-11-16 |
| JP3002552B2 (ja) | 2000-01-24 |
| ITMI910381A0 (it) | 1991-02-14 |
| GB9103278D0 (en) | 1991-04-03 |
| DE4104728A1 (de) | 1991-08-22 |
| PT96789A (pt) | 1991-10-31 |
| KR0169982B1 (ko) | 1999-02-01 |
| KR910015306A (ko) | 1991-09-30 |
| IT1244743B (it) | 1994-08-08 |
| ATA32291A (de) | 1996-07-15 |
| PL289084A1 (en) | 1991-11-04 |
| HU210834B (en) | 1995-08-28 |
| HUT61201A (en) | 1992-12-28 |
| FR2658419A1 (fr) | 1991-08-23 |
| ITMI910381A1 (it) | 1992-08-14 |
| EG19540A (en) | 1995-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |