GB2231045B - Cyclodextrin clathrates of 5-cyano-16 -methylprostacyclin and their use in pharmacetical compositions - Google Patents

Cyclodextrin clathrates of 5-cyano-16 -methylprostacyclin and their use in pharmacetical compositions

Info

Publication number
GB2231045B
GB2231045B GB8916355A GB8916355A GB2231045B GB 2231045 B GB2231045 B GB 2231045B GB 8916355 A GB8916355 A GB 8916355A GB 8916355 A GB8916355 A GB 8916355A GB 2231045 B GB2231045 B GB 2231045B
Authority
GB
United Kingdom
Prior art keywords
methylprostacyclin
cyano
cyclodextrin clathrates
pharmacetical
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8916355A
Other languages
English (en)
Other versions
GB2231045A (en
GB8916355D0 (en
Inventor
Werner Skuballa
Helmut Dahl
Helmut Vorbruggen
Olaf Loge
Karl-Heinz Thierauch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB8916355D0 publication Critical patent/GB8916355D0/en
Publication of GB2231045A publication Critical patent/GB2231045A/en
Application granted granted Critical
Publication of GB2231045B publication Critical patent/GB2231045B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB8916355A 1987-11-27 1989-07-18 Cyclodextrin clathrates of 5-cyano-16 -methylprostacyclin and their use in pharmacetical compositions Expired - Lifetime GB2231045B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873740838 DE3740838A1 (de) 1987-11-27 1987-11-27 Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
PCT/DE1988/000739 WO1989004828A1 (fr) 1987-11-27 1988-11-25 Clathrates de cyclodextrine de derives de 5-cyano-prostacycline et leur emploi comme medicaments

Publications (3)

Publication Number Publication Date
GB8916355D0 GB8916355D0 (en) 1990-07-04
GB2231045A GB2231045A (en) 1990-11-07
GB2231045B true GB2231045B (en) 1992-04-29

Family

ID=6341738

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8916355A Expired - Lifetime GB2231045B (en) 1987-11-27 1989-07-18 Cyclodextrin clathrates of 5-cyano-16 -methylprostacyclin and their use in pharmacetical compositions

Country Status (11)

Country Link
US (1) US5010065A (enExample)
EP (1) EP0349621A1 (enExample)
JP (1) JPH02502379A (enExample)
AT (1) AT396687B (enExample)
BE (1) BE1001327A3 (enExample)
CH (1) CH677790A5 (enExample)
DE (1) DE3740838A1 (enExample)
FR (1) FR2623807B1 (enExample)
GB (1) GB2231045B (enExample)
IT (1) IT1227576B (enExample)
WO (1) WO1989004828A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227372A (en) * 1990-03-07 1993-07-13 Children's Medical Center Corporation Method for retaining ophthalmological agents in ocular tissues
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
DE4135193C1 (enExample) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
US5694021A (en) * 1994-02-28 1997-12-02 Kabushiki Kaisha Toshiba System for executing charge control of a secondary battery and detecting the capacitance thereof
US5896596A (en) * 1997-10-22 1999-04-27 Nitto Kogyo Co., Ltd. Apparatus for generating massaging water stream
JP2009543826A (ja) * 2006-07-18 2009-12-10 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 自己免疫疾患治療剤としての５−シアノ−プロスタサイクリン誘導体
JP5271272B2 (ja) 2006-11-16 2013-08-21 ジェンムス ファーマ インコーポレイティド Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬
KR20120093955A (ko) 2009-10-14 2012-08-23 젬머스 파마 인코포레이티드 바이러스 감염에 대한 병용 요법 치료
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2006193A (en) * 1977-09-23 1979-05-02 Chinoin Gyogyszer Es Vegyeszet Inclusion complexes of prostacyclin and its derivatives, their preparation and pharmaceutical compositions containing them
EP0002234A1 (de) * 1977-11-25 1979-06-13 Schering Aktiengesellschaft Neue Prostacyclinderivate, ihre Herstellung und Anwendung
WO1987005294A1 (fr) * 1986-03-07 1987-09-11 Schering Aktiengesellschaft Cyclodextrineclathrates de derives de carbacycline et leur utilisation comme medicaments

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503362B1 (enExample) * 1970-06-10 1975-02-04
DE2405146A1 (de) * 1974-01-31 1975-08-07 Siemens Ag Mengenmessgeraet mit einem in einer kammer angeordneten rotor
GB2017699B (en) * 1978-03-31 1983-01-12 Ono Pharmaceutical Co 6,9-methano-pgi2 analogues
JPS5540923A (en) * 1978-09-14 1980-03-22 Ono Sokki Co Ltd Flow meter
JPS56150039A (en) * 1980-04-22 1981-11-20 Sankyo Co Ltd Clathrate compound of prostacycline derivative
DE3448257C2 (en) * 1984-07-25 1988-08-18 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De Cytoprotective action of prostacyclin derivatives on the kidney

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2006193A (en) * 1977-09-23 1979-05-02 Chinoin Gyogyszer Es Vegyeszet Inclusion complexes of prostacyclin and its derivatives, their preparation and pharmaceutical compositions containing them
EP0002234A1 (de) * 1977-11-25 1979-06-13 Schering Aktiengesellschaft Neue Prostacyclinderivate, ihre Herstellung und Anwendung
WO1987005294A1 (fr) * 1986-03-07 1987-09-11 Schering Aktiengesellschaft Cyclodextrineclathrates de derives de carbacycline et leur utilisation comme medicaments

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, Vol. 103, No: 20, 18 November 1985, 166008d, *
J. Inclusion Phenom. 1984, 2(3-4), 467-74 *

Also Published As

Publication number Publication date
CH677790A5 (enExample) 1991-06-28
GB2231045A (en) 1990-11-07
ATA901688A (de) 1993-03-15
GB8916355D0 (en) 1990-07-04
FR2623807A1 (fr) 1989-06-02
FR2623807B1 (fr) 1990-08-31
DE3740838A1 (de) 1989-06-08
IT8822760A0 (it) 1988-11-28
EP0349621A1 (de) 1990-01-10
JPH02502379A (ja) 1990-08-02
IT1227576B (it) 1991-04-16
BE1001327A3 (fr) 1989-09-26
US5010065A (en) 1991-04-23
AT396687B (de) 1993-11-25
WO1989004828A1 (fr) 1989-06-01

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19931125