GB2186580B - Purification of recombinant human interleukin-la - Google Patents

Purification of recombinant human interleukin-la

Info

Publication number
GB2186580B
GB2186580B GB8703663A GB8703663A GB2186580B GB 2186580 B GB2186580 B GB 2186580B GB 8703663 A GB8703663 A GB 8703663A GB 8703663 A GB8703663 A GB 8703663A GB 2186580 B GB2186580 B GB 2186580B
Authority
GB
United Kingdom
Prior art keywords
purification
recombinant human
human interleukin
interleukin
recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8703663A
Other languages
English (en)
Other versions
GB2186580A (en
GB8703663D0 (en
Inventor
Alvin Seth Stern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB8703663D0 publication Critical patent/GB8703663D0/en
Publication of GB2186580A publication Critical patent/GB2186580A/en
Application granted granted Critical
Publication of GB2186580B publication Critical patent/GB2186580B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB8703663A 1986-02-18 1987-02-17 Purification of recombinant human interleukin-la Expired - Lifetime GB2186580B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/830,406 US5831022A (en) 1986-02-18 1986-02-18 Purification of recombinant human IL-1α

Publications (3)

Publication Number Publication Date
GB8703663D0 GB8703663D0 (en) 1987-03-25
GB2186580A GB2186580A (en) 1987-08-19
GB2186580B true GB2186580B (en) 1990-08-22

Family

ID=25256938

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8703663A Expired - Lifetime GB2186580B (en) 1986-02-18 1987-02-17 Purification of recombinant human interleukin-la

Country Status (10)

Country Link
US (1) US5831022A (enExample)
JP (1) JP2590085B2 (enExample)
BE (1) BE1000636A5 (enExample)
CH (1) CH676008A5 (enExample)
DE (1) DE3704868C2 (enExample)
DK (1) DK171419B1 (enExample)
FR (1) FR2595714B1 (enExample)
GB (1) GB2186580B (enExample)
IT (1) IT1202565B (enExample)
NL (1) NL8700397A (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3883252T2 (de) * 1987-12-18 1993-11-25 Immunex Corp Örtliche wundheilmittel, die interleukin-1-proteine enthalten.
US5120534A (en) * 1988-07-29 1992-06-09 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and medicament for treating thrombocytopenia
IT1226713B (it) * 1988-08-05 1991-02-05 Eniricerche Spa Procedimento per la preparazione di interleuchina 1 beta umana ricombinante in forma omogenea.
JP2002514886A (ja) * 1994-10-24 2002-05-21 プロメガ コーポレーション クロストリジウム・ディフィシル疾患の治療及び予防のためのワクチン及び抗トキシン

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0118617A2 (en) * 1982-12-15 1984-09-19 Ajinomoto Co., Inc. Interleukin-2 polypeptides
EP0147819A2 (de) * 1983-12-23 1985-07-10 F. Hoffmann-La Roche Ag Reinigung von rekombinanten Interleukin-2
EP0165654A2 (en) * 1984-06-19 1985-12-27 Immunex Corporation Purified interleukin 1
WO1988001624A1 (en) * 1986-09-04 1988-03-10 Immunex Corporation Purification of recombinant interleukin-1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401756A (en) * 1981-04-14 1983-08-30 Immunex Corporation Process for preparing human interleukin 2
GR79124B (enExample) * 1982-12-22 1984-10-02 Genentech Inc
FR2550802B1 (fr) * 1983-08-17 1986-04-11 Inst Nat Sante Rech Med Procede de production d'interleukine 1 humaine et medicaments correspondants
JPS60149386A (ja) * 1984-01-17 1985-08-06 Dainippon Pharmaceut Co Ltd インタ−ロイキン１をコ−ドする伝令リボ核酸及びその調製法
JPS60197629A (ja) * 1984-03-16 1985-10-07 Chemo Sero Therapeut Res Inst ＨＢｓ抗原の精製方法
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
JPS617296A (ja) * 1984-06-19 1986-01-13 イミユネツクス、コ−ポレ−シヨン インタ−ロイキン１の遺伝子の精製、クロ−ニング及び特性づけ
DE3432196A1 (de) * 1984-09-01 1986-03-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Neues mechanisches aufschlussverfahren von bakterienzellen zur isolierung von rekombinant hergestellten peptiden
DE3683186D1 (de) * 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
US4675387A (en) * 1985-07-26 1987-06-23 E. I. Du Pont De Nemours And Company Method for extracting protein with organic acid
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0118617A2 (en) * 1982-12-15 1984-09-19 Ajinomoto Co., Inc. Interleukin-2 polypeptides
EP0147819A2 (de) * 1983-12-23 1985-07-10 F. Hoffmann-La Roche Ag Reinigung von rekombinanten Interleukin-2
EP0165654A2 (en) * 1984-06-19 1985-12-27 Immunex Corporation Purified interleukin 1
WO1988001624A1 (en) * 1986-09-04 1988-03-10 Immunex Corporation Purification of recombinant interleukin-1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Biotechnology 1986 Vol 4 No12 pages 1078 to 1082 *

Also Published As

Publication number Publication date
DE3704868A1 (de) 1987-08-20
CH676008A5 (enExample) 1990-11-30
DK171419B1 (da) 1996-10-21
DE3704868C2 (de) 1995-09-21
BE1000636A5 (fr) 1989-02-28
FR2595714B1 (fr) 1990-05-18
GB2186580A (en) 1987-08-19
DK77387D0 (da) 1987-02-16
IT8719420A0 (it) 1987-02-18
NL8700397A (nl) 1987-09-16
JP2590085B2 (ja) 1997-03-12
DK77387A (da) 1987-08-19
FR2595714A1 (fr) 1987-09-18
IT1202565B (it) 1989-02-09
JPS62209097A (ja) 1987-09-14
US5831022A (en) 1998-11-03
GB8703663D0 (en) 1987-03-25

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19980217