GB2129691A - Devices for administering medicaments to patients - Google Patents

Devices for administering medicaments to patients Download PDF

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Publication number
GB2129691A
GB2129691A GB08326878A GB8326878A GB2129691A GB 2129691 A GB2129691 A GB 2129691A GB 08326878 A GB08326878 A GB 08326878A GB 8326878 A GB8326878 A GB 8326878A GB 2129691 A GB2129691 A GB 2129691A
Authority
GB
United Kingdom
Prior art keywords
chamber
support
medicament
carrier
mouthpiece
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08326878A
Other versions
GB8326878D0 (en
GB2129691B (en
Inventor
Robert Edward Newell
Robert Alexander Fitzsimmons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838314307A external-priority patent/GB8314307D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of GB8326878D0 publication Critical patent/GB8326878D0/en
Publication of GB2129691A publication Critical patent/GB2129691A/en
Application granted granted Critical
Publication of GB2129691B publication Critical patent/GB2129691B/en
Priority to MYPI87002698A priority Critical patent/MY102120A/en
Priority to SG6989A priority patent/SG6989G/en
Priority to KE386189A priority patent/KE3861A/en
Priority to HK67689A priority patent/HK67689A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems
    • A61M2205/6081—Colour codes

Description

1
SPECIFICATION
Devices for administering medicaments to patients This invention relates to devices by which a medicament can be administered to or by patients inhaling through the devices. The medicaments may be in solid finely divided form orfluid form. Such devices are now quite well known for administering medicaments contained in capsules to patients suffer ing from bronchial conditions such as, for example, bronchial asthma. It is well known for medicament in powderor other dinely divided form to be supplied in capsules which are loaded by a patient into such a device which is sometimes called an "insufflator". The medicament isthen released from the capsule and inhaled bythe patient, usuallythrough the mouth, but sometimes through the nose.
The specifications of PCTApplication Publication
No. W082/01470 and U.K. Patent Specification No. 85
1387954 both described devices for dispensing medicament in finely divided form from capsules. In each of these previously described devices, the capsules are mounted on a rotatable support member on which each capsule in turn can be broughtto a 90 position in which it is opened to enable medicamentto exitfrom the capsule to permit itto be inhaled by a patient inhaling through a mouthpiece of the device.
In the device described in U.K. Specification No.
1387954, the capsules may be mounted in a so-called 95 blister pack.
There are disadvantages in the use of capsules, which are made of gelatin, to contain medicaments.
Gelatin is relatively unstable and is lacking in physical strength so thatthe capsules need to be protected by 100 packaging, for example in glass bottles. Environmen tal degradation of both the capsules and their contents may occure in a relatively shorttime.
An object of the present invention is to provide a more convenient way of administering medicament 105 to such patients than has been possible hitherto and which avoidsthe need to pack medicaments in capsules. The device of the present invention makes use of thetechnique of packing medicament by loading them in blister packs, that is to say packs 110 comprising a sheet, which may be laminated, of foil or plastics material which acts as a carrier and which is provided with a number of breakable or openable containers called "blisters" incorporating a sheet secured on a first sheetto form a cover or lid. Such blister packs are in common use with tablets of one kind or another, butwe have discovered that they can also be used with medicaments in finely divided solid form or in liquid form.
According to the present invention a device for administering medicaments to patients comprises a housing with a cylindrical chambertherein; an air inlet into the chamber; a support insidethe chamber arranged to support a carrier provided with a contain- erfor medicament or a plurality of containers arranged in a circle; a plunger operableto engage a container registered therewith to open the container in such a way that air being inhaled by a patient will cause the medicamentto be released therefrom; means for rotating a carrier on the support to register GB 2 129 691 A 1 the container, or each ofthem inturn, with the plunger; and communicating with the interiorof the chamber, an outletthrough which a patientcan inhale whereby medicamentwill be releasedfrom a contain- erand entrained in theairflow produced bythe patient so asto passthroughthe outlet. The outletis conveniently but not essentially a mouthpiece by which a patient can inhale.
The device of the invention is suitablefor admi- nistering a variety of medicaments such as, for example, salbutamol, beclomethasone dipropionate and disodiurn cromoglycate.
Some embodiments of the invention are illustrated in the accompanying schematic drawings in which; Figure 1 is an exploded perspective view of a device according to one embodiment of the invention; Figure 2 is a detailed view of a plunger device of the same device; Figure 3 is an elevation of another embodiment of the invention; Figure 4 is an exploded view of the embodiment illustrated in Figure 3, and Figure 5 is a perspective view of yet another embodiment of the invention.
In the embodiment of the invention illustrated in Figures 1 and 2 of the drawings, a medical administration device comprises a shallow cylindrical housing 1 of a plastics material which has a cylindrical chamber 2 therein. The chamber is closed at one end 3, herein considered the bottom of the chamber, and a removable cover 4 is a close fit overthe chamber atthe other end.
A mouthpiece outlet 5 projects outwardlyfrorn the cylindrical wall of the housing 1 and communicates with the interior of the chamber 2. A perforated guard, not shown, is provided in the mouthpieceto prevent any solid particles of an undesirably large size being inhaled by a patient inhaling through the mouthpiece.
A rim orshoulder 6 runs round the inside wall of the chamber 2 to provide an annular support on which a blister pack7 may be located.
The blister pack 7 can conveniently be a foil laminate with a plurality of frangible containers or "blisters" 8 arranged in a circle. The blisters 8 are filled with medicament in particulate form, having a particle size in the range of 0.5 - 10 microns. The medicament may be with a pharmaceutically acceptable carrier such as lactose or starch in particulate form. Alternatively, the medicament may be in liquid form. The blister pack is of circular discform, and is removablyfitted inside the chamber so that it is replaceable when the individual doses of medicament contained in the blisters have been discharged.
The chamber 2 contains a central open cylindrical support column 9 upstanding from the bottom wall 3 of the chamber. A clamp disc member 10 is removably fitted inside the chamber 2 and has on its underside a plurality of locating pegs, not shown, which engage inside the support column. The clamp member 10 is rotatable inside the chamber. In use, the clamp member is placed on top of a blister pack 7 which has already been loaded into the chamber and is located on the support shoulder 6. The blister pack7 is preferably a circular disc of foil laminate material with blisters or containers 8. The clamp member 10 has a 2 plurality of apertures 11 which are arranged in a circle and so spaced from each other that each of them will receive one of the blisters 8 of the blister pack 7. A knob 12 is upstanding from the clamp member 10 and when the lid 4 is fitted on the housing 1 the knob 12wil 1 70 project through an aperture 13 in the top of the lid 4.
This knob can be turned by the patient to rotate the clamp member 10 and since the blisters 8 of the blister pack 7 are located in the apertures 11 in the clamp plate 10 rotation of the clamp mem ber wil I also rotate 75 the blister pack. A plurality of protuberances or pips 14 are provided on the top of the clamp member 10 and engage in a recess 15, Figu re 2, on the underside of the cover 4 to make sure that the clamp plate is correctly aligned in position. As wil I be seen, the knob 12 is 80 fluted to provide openings between the knob and the hole 13 through which air can enterthe chamber 2 from the outside.
The cover 4 also has an aperture 16 in which a plunger 17 contained in a plunger housing 18 can be 85 received. The plunger has an annular shoulder 19 and a spring 20 can bear between the shoulder 19 and the bottom of the plunger housing 18 to urge the plunger into an upper or inoperative position. The plunger may be provided with a knife edge 21 or other means 90 to enable the blisterto be opened. When the plunger 17 is depressed against the action of the spring 20, the lower edge portion 21 of the plungerwill pass through an aperture 22 in the plunger housing to passthrough a blister 8 located in registerwith the plunger. Such 95 engagementwill open the blister, and permitthe release of medicament therefrom. This action will so open the blisterthat when a patient inhales airwill pass through the blister, the medicament being entrained in the airflow and exiting through the 100 mouthpiece 5 via a transfer cavity 23 inside the chamber in communication with the mouthpiece 5. By rotation of the knob 12the clamp member 10 and the blister pack 7 can be rotated to bring each blister in turn into location beneath the plunger. The various 105 protuberances or pips 14 will in turn engage in the recess 15 to make sure that the blister pack is correctly registered with the plunger.
It is not essential that the plunger have a knife 21 to - open the blister. If desired a needle can be used to 110 perforate the blister orthe plunger may have a pointed end or even a blunt end or another convenient opening means my be used.
The mouthpiece cover can have a locking member 24which can be engaged with the plunger when the 115 device is not in use to prevent accidental actuation of the plunger.
In use,the patient needing a dose of medicament may hold the device with the mouthpiece in his mouth.The patientthen depressesthe plungerto openthe blisterand give accesstothe medicament therefrom and inhales through the mouthpiece so that the medicamentwill be entrained inthe airflowand will enterthe I u ngs of the patient. If desired, the mouthpiece can be provided with air inlet apertures 25 to improve the air flow as the patient inhales.
Ina modification no illustrated the underside of the blister pack can be supported on another clamp plate instead of the support rim or shoulder 6.
The blister pack is conveniently arranged to provide 130 GB 2 129 691 A 2 a sufficient number of individual dosesfora patientfor use during a convenient period such as one day or more. The housing can be modified by providing an additional chamber, not visible, atthe bottom, this additional chamber being closed by a removable cover 26. This additional chamber can be used to store replacement blister packs.
The mouthpiece may, if desired, be arranged so that a patient may use itto inhale through the nose.
A modified device which does not usethe clamp member 10 is illustrated in Figures 3 and 4. The device of this modification comprises a housing 30 having a chamber31 therein. A mouthpiece 32 projects outwardlyfrom the cylindrical wall of the housing 30 in a generally radial direction and communicates with the interior of the chamber 31. A perforated guard 33 is provided atthe entrance to the mouthpiece 32. A rim orshoulder34 runs round the inside wall of the chamber 31 to provide an annularsupport for a support member35 in the form of a circular plate or disc. This support member is arranged to receive a blister pack 36. The blister pack 36 has a plurality of frangible containers 37 arranged in a circular row. These containers are in theform of -blisters" of a generally conical form as clearly shown in Figure 4 and contain a medicament as described with reference to Figure 1. The support member35 has a plurality of holes 38 equal in numberto the number of blisters 37 of the blister pack 36. The conical portion of one blister37 is located in each of the holes 38 when the device is loaded and in use. An external rotatable member39 with a knurled edge 40 is located in face contactwith the bottom of the housing 30. Aspindle or the like 41 with radial projections 42 extends centrally from the support member35through a hole 43 in the bottom of the housing 30 and into an opening 44 of complementary shape in a spigot 45 of the member 39. The spigot45 passes through the hole 43 and the spindle 41 and 42 engages in the opening 44 so that rotation of the member 39 will cause similar rotation to the support member 35. A removable cover 46 fits on top of the housing 30. An opening 47 is provided in the cover 46 and engages a projection 48 in the housing 30 so as correctlyto locate the cover. The cover 46 carries a bracket 49 on which a lever ortrigger 50 is pivotally mounted. A plunger 51 is located on the lever ortrigger 50 and extends through a hole 52 in the cover. A spring 53 is provided to bear between the trigger or lever 50 and the top of the cover 46 to urge the lever ortrigger upwards.
The hole 52 is so positioned that each hole 38 in the su pport member 35 wil 1 registerwith this hole as the support member35 is rotated.
When one of the holes 38 is in registerwith the hole 52thetrigger 50 can be depressed so that its plunger 51, which may be intheform of a needle,will pierce through the blister37 located in that hole (i.e. pierce thetop andthe bottom of the blister) therebyto permit powderto exitfrom the blister. Some powderwill fall into atray-like compartment 54 inside the chamber 31. When the patientinhales, air passesthrough the pierced blistersothat powderwill be entrained in the airflowand will,with powderfrom the compartment 54, be withdrawn through the guard 33 andthe ice is not in use, the mouthpiece 32. When the devi 3 GB 2 129 691 A 3 mouthpiece32can beenclosed in a mouthpiece cover orsheath 55which has a channel-like extension 56 which will engagewith the bracket49to preveritthe plunger51 being depressed to enterth rough the hole 37.
When the device is in use and the patient inhales through the mouthpiece 32 it is, of course, essential for airto be able to enterthe interior of the chamber31.
Any suitable air inlets can be provided. Conveniently, however, air can enterthrough the hole 52 the plunger or needle 51 being smaller in diameterthan the diameter of the hole 52 so that it serves as an air inlet.
Figure 5 illustrates a modified device which can conveniently be used to administertwo different medicaments to a patient at separate times. Treat ment of certain patients does require that they inhale two different kinds of medicament. In the device illustrated in Figure 5, a common housing 57 contains two chambers equivaleritto the chamber 2 of the embodiment illustrated in Figure 1 and 2 orto the 85 chamber31 of the embodiment illustrated in Figures 3 and 4. These two chambers are enclosed by remov able covers 58 and blister packs contained in the chambers can be rotated in the manner previously described by rotation of knurled wheels, knobs or other members 59. Outlet mouthpieces 60 project outwardlyfrom the common housing 57, each one of these outlets 60 leading into one of the chambers enclosed bythe common housing. Trigger mechan isms 61 are provided to enable the blisters of the blister packs contained in the chambers to be pierced so that the contents thereof can be inhaled by the patient.

Claims (17)

CLAIMS:
1. A device for administering medicaments to patients comprises a housing with a cylindrical chambertherein; an air inlet into the chamber; a support insidethe chamber arranged to support a carrier provided with a containerfor medicament or a plurality of containers arranged in a circle; a plunger operable to engage a container registered therewith to open the container in such a way that air being inhaled by a patient will causethe medicamentto be released therefrom; means for rotating a carrier on the supportto registerthe container, or each of them in turn,with the plunger; and, communicating with the interior of the chamber, an outletthrough which a patient can inhale whereby medicamentwill be released from a container and entrained in the airflow produced by the patient so as to pass through the 115 outlet.
2. A device as claimed in claim 1 wherein the support is a rotatable plate with a plurality of holes therethrough,the holes being arranged in a circle and each being adapted to receive a containerfor medica- 120 ment, a rotatable member is located outside the chamber and is connected with the support so that rotation of the said member will cause rotation of the support; a mouthpiece outlet leads out of the chamber in a substantially radial direction; and a perforated guard is positioned so that air and medicament inhaled through the mouthpiece will first pass through theguard.
3. A device as claimed in claim 1 wherein the support is a rim inside the chamber and a clamp member is fitted inside the chamber and on the support but is removable to permit a carrier to be placed on the support and thereafter clamped between the clamp member and the support, the clamp member having a plurality of holes arranged in a circle to receive a plurality of containers and being rotatable and arranged to rotate with it a carrier clamped between the clamp member and the support and wherein an external knob is provided to rotate the clamp member and an outlet mouthpiece leads substantially radiallyfrom the chamber.
4. A device as claimed in anyone of the preceding claims wherein the chamber has a cover which is removable to permit a carrier to be inserted in the chamber and placed on the support, the plunger being carried by the cover.
5. Adevice as claimed in claims 2 or3wherein the mouthpiece is enclosed in a removable mouthpiece cover, said mouthpiece cover having means for preventing operation of the plunger when the mouthpiece cover is fitted on the mouthpiece.
6. A device as claimed in anyone of the preceding claims wherein the carrier is a circular disc having a plurality of frangible containers arranged in a circle and containing a medicament in particulate form.
7. A device forthe administration of medicaments to a patient wherein a plurality of devices as claimed in any one of claims 1 to 5 is located in a common housing.
8. A device for administering medicaments to patients substantially as described with reference to any of the Figures of the accompanying drawings.
9. Two devices as claimed in anyone of the preceding claims located in a common housing.
10. A pack comprising a circular carrier disc provided with a plurality of containers arranged in a circle and each containing a dose of medicament in particulate form, the containers being openable to permitthe medicament therein to be released.
11. A packas claimed in claim 10wherein the containers are of generally conical form.
12. Apackas claimed in eitherof claims 10 orl 1 wherein the carrier disc is of foil laminate material.
13. Apackasclaimed in anyof claims 10- 12 wherein the medicaments are salbutamol and beclomethasone dipropionate in particulate form.
14. A packas claimed in anyone of claims 10- 12 wherein the medicament is sodium cromoglycate in particulate form.
15. Apackasclaimed in eitherof claims 13orl4in which the particle size of the medicament is substantially in the range 0.5 - 10 microns.
16. Apackasclaimed in anyone of claims 10 - 15 in which the medicament is admixed with a solid pharmaceutically acceptable carrier.
17. Apackas claimed in claim 16 in whichthe carrier is lactose.
Printed for Her Majesty's Stationery Office byTheTweeddale Press Ltd., Berwick-upon-Tweed, 1984. Published atthe Patent Office, 25 Southampton Buildings, London WC2A lAY, from which copies may be obtained.
GB08326878A 1982-10-08 1983-10-07 Devices for administering medicaments to patients Expired GB2129691B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
MYPI87002698A MY102120A (en) 1983-05-24 1987-10-01 Devices for administering medicaments to patients
SG6989A SG6989G (en) 1982-10-08 1989-02-09 Medicament-containing pack
KE386189A KE3861A (en) 1982-10-08 1989-02-15 Medicament-containing pack
HK67689A HK67689A (en) 1982-10-08 1989-08-24 Medicament-containing pack

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8228887 1982-10-08
GB838314307A GB8314307D0 (en) 1983-05-24 1983-05-24 Medical administration devices

Publications (3)

Publication Number Publication Date
GB8326878D0 GB8326878D0 (en) 1983-11-09
GB2129691A true GB2129691A (en) 1984-05-23
GB2129691B GB2129691B (en) 1987-08-05

Family

ID=26284076

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08326878A Expired GB2129691B (en) 1982-10-08 1983-10-07 Devices for administering medicaments to patients

Country Status (30)

Country Link
US (1) US4627432A (en)
JP (2) JPH05200100A (en)
KR (1) KR910002248B1 (en)
AT (1) AT396333B (en)
AU (2) AU570013B2 (en)
BR (1) BR8305562A (en)
CA (1) CA1224992A (en)
CH (1) CH662277A5 (en)
CY (2) CY1478A (en)
DE (1) DE3336486A1 (en)
DK (1) DK172541B1 (en)
ES (1) ES286422Y (en)
FI (1) FI79651C (en)
FR (2) FR2550452B1 (en)
GB (1) GB2129691B (en)
GR (1) GR79615B (en)
HK (1) HK67789A (en)
IE (1) IE56059B1 (en)
IL (1) IL69932A (en)
IN (1) IN160851B (en)
IT (1) IT1203660B (en)
KE (1) KE3860A (en)
LU (1) LU85034A1 (en)
NL (1) NL192564C (en)
NO (1) NO160330C (en)
NZ (1) NZ205892A (en)
PT (1) PT77471B (en)
SE (2) SE458824B (en)
SG (1) SG6889G (en)
ZW (1) ZW21483A1 (en)

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FR2550452B1 (en) 1992-05-22
ZW21483A1 (en) 1985-05-08
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NO160330B (en) 1989-01-02
AT396333B (en) 1993-08-25
FR2550452A1 (en) 1985-02-15
PT77471B (en) 1986-08-19
SE8305542D0 (en) 1983-10-07
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HK67789A (en) 1989-09-01
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IL69932A (en) 1987-12-31
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