DK173079B1

DK173079B1 - Hand-held inhaler for powder or liq. medical inhalants - which are in dose sized blisters of circular disc blister pack

Info

Publication number: DK173079B1
Application number: DK199800451A
Authority: DK
Inventors: Robert Edward Newell; Robert Alexander Fitzsimmons
Original assignee: Glaxo Group Ltd
Priority date: 1982-10-08
Filing date: 1998-03-31
Publication date: 1999-12-20
Also published as: DK45198A

Abstract

Patient can inhale a powder or liq. via mouth or nostril for the treatment of bronchial complaints etc.. The inhaler comprises a shallow, cylindrical box inside which a circular disc blister-pack of plastic ampoules contg. inhalant is supported to be rotatably coaxially with the box. The ampoules are evenly spaced around a circle centred on the axis of disc rotation. The blister-pack is rotated by a plate which sits on top of the pack, engaging each ampoule in a hole in the plate. The plate has an axial button projecting through the lid of the box for turning the plate and blister-pack. The plate has register catches on a pitch circle to locate the plate with each ampoule in turn beneath a spring-loaded plunger which can be depressed to break open the ampoule. Once the inhalant is released, the patient sucks or inhales by nostril from a box outlet pipe. The ampoules are much more stable and have greater shelf life than gelatin capsules, previously used to contain inhalants. The blister-packs are inexpensive to make and easy to store. Several packs can be carried in a false bottom of the inhaler.

Description

DK 173079 B1DK 173079 B1

Opfindelsen vedrører en medikamentpakning, der omfatter en cirkulær bæreskive med flere beholdere, der er udformet i ét med bæreskiven og er placeret i en cirkel, og som hver indeholder en dosis af et medikament i findelt form. Ved hjælp af en sådan pakning kan et me-5 dikament administreres til eller af en patient ved inhalering gennem et apparat. Sådanne apparater er i dag ganske velkendte til administrering af medikamenter, som er indeholdt i kapsler, til patienter, der lider af lungesygdomme, såsom fx bronkial astma. Det er til et medikament i pulverform eller anden findelt form kendt at frembringe 10 medikamentet i kapsler, der af en patient indføres i et sådant apparat, som undertiden kaldes en "insufflator". Medikamentet frigøres derefter fra kapslen og inhaleres af patienten, sædvanligvis gennem munden, men undertiden gennem næsen.The invention relates to a medicament package comprising a multi-container circular carrier disc, formed integrally with the carrier disc and placed in a circle, each containing a dose of a medicament in comminuted form. By means of such a package, a drug can be administered to or by a patient by inhalation through an apparatus. Such devices are nowadays quite well known for the administration of medications contained in capsules to patients suffering from pulmonary diseases, such as, for example, bronchial asthma. It is known for a medicament in powder or other finely divided form to produce the medicament in capsules introduced by a patient into such an apparatus, sometimes called an "insufflator". The drug is then released from the capsule and inhaled by the patient, usually through the mouth but sometimes through the nose.

I beskrivelserne til PCT-anssgningen, publikationsnr. W082/01470, og 15 GB patentskrift nr. 1387954 er der beskrevet apparater til afgivelse af et medikament i findelt form fra kapsler. I hvert af disse tidligere beskrevne apparater er kapslerne monteret på en drejelig understøtningsdel, på hvilken hver kapsel efter tur kan føres til en stilling, i hvilken den åbnes for at muliggøre, at medikamentet kan afgives fra 20 kapslen for at tillade, at det kan inhaleres af en person, som inhalerer gennem apparatets mundstykke. I det i GB patentskrift nr. 1387954 beskrevne apparat kan kapslerne vare monteret i en såkaldt "blisterpakning" .In the descriptions of the PCT application, publication no. WO82 / 01470 and 15 GB patent specification 1387954 disclose apparatus for dispensing a drug in finely divided form from capsules. In each of these previously described apparatus, the capsules are mounted on a swivel support member, on which each capsule may in turn be guided to a position in which it is opened to allow the drug to be dispensed from the capsule to allow it to be inhaled. by a person inhaling through the mouthpiece of the apparatus. In the apparatus described in GB patent no. 1387954, the capsules may be mounted in a so-called "blister pack".

GB patentskrift 1 075 679 beskriver en cirkulær beholder til faste me-25 dikamenter såsom p-piller.GB Patent 1,075,679 discloses a circular container for solid drugs such as birth control pills.

FI patentskrift 29 003 beskriver en medikamentpakning i form af et bånd, der indeholder doser af et medikament, og som kan trækkes ud af en beskyttelsesbeholder således at en dosis af medikamentet frigøres, når båndet trækkes ud af beholderen.FI Patent 29,003 discloses a drug package in the form of a tape containing doses of a drug and which can be withdrawn from a protective container so that a dose of the drug is released as the tape is pulled out of the container.

30 SE patentskrift 210 822 beskriver en båndformet portionspakning til fx tabletter og pulverformige produkter, hvor de enkelte portioner kan frigøres enkeltvis.30 SE patent 210 822 discloses a band-shaped portion pack for, for example, tablets and powdered products, where the individual portions can be released individually.

Der er imidlertid uletrøer forbundet med brugen af kapsler, der er fremstillet af gelatine, og som indeholder medikamenter. Gelatine er 35 relativt ustabilt og mangler fysisk styrke, så at kapslerne skal beskyttes ved emballering, fx i glasflasker. Miljønedbrydning af både kapslerne og deres indhold kan ske i løbet af relativt kort tid.However, there are drawbacks associated with the use of gelatin-made capsules containing medications. Gelatin is relatively unstable and lacks physical strength so that the capsules must be protected by packaging, for example in glass bottles. Environmental degradation of both the capsules and their contents can occur in a relatively short time.

Ved en medikamentpakning af den indledningsvis nævnte art undgås nødvendigheden af indpakning af medikamenterne i kapsler. Et egnet DK 173079 B1 2 apparat gør brug af medikamentemballeringsteknikken ved tilførsel af medikamenterne i blisterpakninger, dvs. emballager, der har en folie, som kan være lamineret, af plastmateriale, og som virker som en bærer, og som har flere beholdere, der kaldes "blister", som kan brydes eller 5 åbnes, og som har en folie, der er fastgjort på en første folie til dannelse af et dæksel eller låg. Sådanne blisterpakninger er i almindelig brug i forbindelse med tabletter af forskellige typer, men det har vist sig, at de også kan benyttes i forbindelse med medikamenter i findelt fast form.In a drug package of the kind mentioned above, the necessity of packaging the drugs in capsules is avoided. A suitable DK 173079 B1 2 apparatus makes use of the drug packaging technique when administering the drugs in blister packs, ie. packaging which has a laminated, plastic-laminated film and acts as a carrier, and has several containers called "blisters" which can be broken or opened and which have a film that is attached on a first foil to form a cover or lid. Such blister packs are in common use with tablets of various types, but it has been found that they can also be used in conjunction with drugs in finely divided solid form.

10 Formålet med opfindelsen er at tilvejebringe en medikamentpakning af den indledningsvis nævnte art, som kan tømmes effektivt af den luftstrøm, som passerer til patienten og derved sikre, at denne får tilført en korrekt dosis medikament.The object of the invention is to provide a drug package of the kind mentioned above, which can be effectively emptied of the air flow passing to the patient, thereby ensuring that it is supplied with a correct dose of drug.

Formålet opnås ved at indrette den indledningsis nævnte medikament-15 pakning sådan, at beholderne er indrettet til at kunne gennemhulles på begge sider af bæreskiven sådan, at luft kan strømme gennem beholderen og optage medikamentet i luftstrømmen.The object is achieved by arranging the medicament package mentioned in the preamble so that the containers are arranged to be permeable on both sides of the carrier disk so that air can flow through the container and receive the drug into the air flow.

Et egnet apparat til administrering af et medikament indeholdt i en medikamentpakning ifølge opfindelsen kan eksempelvis være udformet med 20 et hus med et cylindrisk kammer, et luftindløb til kammeret, en understøtning, der er placeret inden i kammeret, og som er indrettet til at understøtte en bærer, som har en beholder til et medikament eller flere beholdere, der er placeret i en cirkel, et stempel, der kan aktiveres til at indgribe med en beholder, der er placeret ud for 25 stempelet, til at åbne beholderen på en sådan måde, at luft, som inhaleres af en patient, får medikamentet til at blive frigjort fra beholderen, organer til drejning af en bærer på understøtningen til anbringelse af beholderen eller hver af disse efter tur ud for stemplet samt et udløb, der står i forbindelse med kammerets indre, og 30 gennem hvilket en patient kan inhalere, hvorved medikamentet frigøres fra en beholder og føres med i den luftstrøm, som frembringes af patienten, så at medikamentet føres gennem udløbet. Udløbet er passende, men ikke nødvendigvis et mundstykke, gennem hvilket patienten kan inhalere.A suitable apparatus for administering a medicament contained in a medicament pack according to the invention may, for example, be provided with a housing with a cylindrical chamber, an air inlet to the chamber, a support located within the chamber and adapted to support a carrier having a container for a drug or several containers placed in a circle, a piston which can be activated to engage with a container located next to the piston to open the container in such a manner; air being inhaled by a patient causes the drug to be released from the container, means for rotating a carrier on the support for placing the container or each of them in turn off the plunger, and an outlet communicating with the interior of the chamber and through which a patient can inhale, thereby releasing the medicament from a container and passing it into the air stream produced by the patient so that the medicament the passage is passed through the outlet. The outlet is appropriate, but not necessarily a mouthpiece through which the patient can inhale.

35 Medikamentpakningen ifølge opfindelsen er egnet til administrering af mange forskellige medikamenter, såsom salbutamol, bechlomethason-dipropionat og dinatrium-chromoglycat.The drug package of the invention is suitable for the administration of many different drugs such as salbutamol, bechlomethasone dipropionate and disodium chromoglycate.

Opfindelsen vil i det følgende blive nærmere forklaret under henvisning til tegningen, på hvilken 3 DK 173079 B1 fig. 1 viser en første udførelsesform for et apparat til administration af medikamenter, adskilt og set i perspektiv, fig. 2 detaljeret en stempelindretning i dette apparat, fig. 3 en anden udførelsesform for et apparat til administration af 5 medikamenter, set fra siden, fig. 4 den i fig. 3 viste udførelsesform, vist adskilt og fig. 5 endnu en udførelsesform for et apparat til administration af medikamenter, set i perspektiv.The invention will be explained in more detail below with reference to the drawing, in which FIG. 1 is a perspective view of a first embodiment of an apparatus for administering drugs; FIG. 2 shows in detail a piston device in this apparatus; FIG. 3 is a side view of another embodiment of an apparatus for administering 5 drugs; FIG. 4 is the one shown in FIG. 3, shown separately and FIG. 5 is another perspective view of an apparatus for administering drugs.

I fig. 1 og 2 er vist en udførelsesform for et apparat til administre-10 ring af et medikament indeholdt i en medikamentpakning ifølge opfindelsen og med et lavt cylindrisk hus 1, der er fremstillet af plastmateriale og har et cylindrisk kammer 2. Rammeret er lukket i den ene ende 3, som i det følgende benævnes kammerets bund, og et aftageligt dæksel 4 passer stramt over kammeret i den anden ende.In FIG. 1 and 2, there is shown an embodiment of an apparatus for administering a medicament contained in a medicament package according to the invention and with a low cylindrical housing 1 made of plastic material and having a cylindrical chamber 2. The frame is closed in one end 3, which is hereinafter referred to as the bottom of the chamber, and a removable cover 4 fits tightly over the chamber at the other end.

15 Et mundstykkeudløb 5 rager udefter fra huset l's cylindriske væg og står i forbindelse med kammeret 2's indre. En perforeret beskyttelsesplade, der ikke er vist, er monteret i mundstykket for at forhindre eventuelle faste partikler med en uønsket stor størrelse i at blive inhaleret af en patient, som inhalerer gennem mundstykket.A nozzle outlet 5 protrudes outwardly from the cylindrical wall of the housing 1 and communicates with the interior of the chamber 2. A perforated protective plate, not shown, is mounted in the mouthpiece to prevent any solid particles of undesirably large size from being inhaled by a patient inhaling through the mouthpiece.

20 En rand eller skulder 6 løber rundt langs kammeret 2's indervæg for at frembringe en ringformet understøtning, på hvilken en blisterpakning eller emballage kan være placeret.A rim or shoulder 6 runs around the inner wall of the chamber 2 to provide an annular support on which a blister pack or package may be located.

Pakningen 7 kan passende være et folielaminat med flere beholdere, der let brydes, eller blister 8, der er placeret i en cirkel. Blisterne B 25 er fyldt med et medikament i findelt form med en partikelstørrelse i området 0,5-10 μηη. Medikamentet kan have en farmaceutisk acceptabel bærer såsom lactose eller stivelse i findelt form. Pakningen har cirkulær skiveform og passer udskifteligt inden i kammeret, så at den kan udskiftes, når de enkelte medikamentdoser, der er indeholdt i 30 blisterne, er afgivet.Suitably, the gasket 7 may be a multi-container foil laminate which is easily broken or blister 8 placed in a circle. Blisters B 25 are filled with a drug in finely divided form with a particle size in the range of 0.5-10 µηη. The drug may have a pharmaceutically acceptable carrier such as lactose or starch in comminuted form. The package has a circular disc shape and fits interchangeably within the chamber so that it can be replaced when the individual drug doses contained in the blisters are dispensed.

Kammeret 2 har en central åben cylindrisk vinderstøtningssøjle 9, der står op fra kammerets bundvæg 3. En fastspændingspladedel 10 passer aftageligt inden i kammeret 2 og har på sin underside flere lokaliseringstappe, der ikke er vist, og som indgriber med indersiden af 35 understøtningssøjlen. Fastspændingsdelen 10 kan dreje inden i kammeret. Under brug anbringes fastspændingsdelen oven på en pakning 7, der allerede er placeret inden i kammeret på understøtningsskulderen 6.The chamber 2 has a central open cylindrical winch support column 9 which rises from the bottom wall of the chamber 3. A clamping plate portion 10 removably fits within the chamber 2 and has on its underside several locating pins which are not shown and which engage with the inside of the support column. The clamping member 10 can rotate within the chamber. In use, the clamping member is placed on top of a gasket 7 already located inside the chamber of the support shoulder 6.

Pakningen 7 er fortrinsvis en cirkulær skive af lamineret foliemateriale med blister eller beholdere 8. Fastspændingsdelen 10 har flere 40 åbninger 11, der er placeret på en cirkel og med sådan indbyrdes DK 173079 B1 4 afstand fra hinanden, at hver af disse åbninger kan optage en af pakningen 7’s blister 8. En knap 12 strækker sig opad fra fastspændings-delen 10, og når låget 4 er monteret på huset 1, rager knappen 12 op gennem en åbning 13 i toppen af låget 4. Denne knap kan drejes af 5 patienten til drejning af fastspændingsdelen 10, og da pakningen 7's blister 8 er placeret i fastspændingspladen 10's åbninger 11, får drejning af fastspændingsdelen også pakningen til at dreje. På oversiden af fastspændingsdelen 10 findes der flere fremspring eller knaster 14 til indgreb i en udsparing 15, der er vist i fig. 2, på 10 undersiden af dækselet 4 til at sikre, at fastspændingspladen er korrekt placeret på plads. Som det fremgår af figuren, er knappen 12 riflet til frembringelse af åbninger mellem knappen og hullet 13, gennem hvilke der kan passere luft ind i kammeret 2 udefra.The gasket 7 is preferably a circular disc of laminated film material with blisters or containers 8. The clamping member 10 has several 40 openings 11 which are placed on a circle and spaced apart from each other such that each of these openings can receive a of the blister 8 of the gasket 7. A button 12 extends upwardly from the clamping member 10, and when the lid 4 is mounted on the housing 1, the button 12 protrudes through an opening 13 at the top of the lid 4. This button can be rotated by the patient to rotating the clamping member 10, and since the blister 8 of the gasket 7 is located in the openings 11 of the clamping plate 10, turning the clamping member also causes the gasket to rotate. On the upper side of the clamping member 10 there are several projections or knobs 14 for engagement in a recess 15 shown in FIG. 2, on the bottom 10 of the cover 4 to ensure that the clamping plate is properly positioned. As can be seen in the figure, the knob 12 is grooved to provide openings between the knob and the hole 13 through which air can pass into the chamber 2 from the outside.

Dækselet 4 har også en åbning 16, i hvilken et stempel 17, der er 15 indeholdt i et stempelhus 18, kan optages. Stempelet har en ringformet skulder 19, og mellem skulderen 19 og bunden af stempelhuset 18 er der lejret en fjeder 20 til at tvinge stempelet til en åben eller inopera-tiv stilling. Stempelet kan have en skarp æg 21 eller et andet organ til at muliggøre, at blisterne kan åbnes. Når stempelet 17 trykkes ned 20 mod fjederen 20's virkning, passerer stempelets nederste skærende del 21 gennem en åbning 22 i stempelhuset og passerer gennem en blist 8, der er placeret ud for stempelet. Dette indgreb åbner blisten og tillader frigivelse af medikament fra samme. Denne virkning vil åbne blisten, så at når en patient inhalerer, vil luft passere gennem 25 blisten og føre medikamentet med i luftstrømmen og afgive det gennem mundstykket 5 via et overførselshulrum 23, der er placeret inden i kammeret, og som står i forbindelse med mundstykket 5. Ved drejning af knappen 12 kan fastspændingsdelen 10 og pakningen 7 bringes til at dreje, så at hver blist efter tur anbringes på plads under stempelet.The cover 4 also has an opening 16 in which a plunger 17, contained in a plunger housing 18, can be accommodated. The piston has an annular shoulder 19, and between the shoulder 19 and the bottom of the piston housing 18, a spring 20 is mounted to force the piston into an open or inoperative position. The plunger may have a sharp egg 21 or other means to enable the blisters to be opened. As the piston 17 is pressed down 20 against the action of the spring 20, the lower cutting portion 21 of the piston passes through an opening 22 in the piston housing and passes through a blister 8 located adjacent to the piston. This intervention opens the blister and allows the release of drug from the same. This effect will open the blister so that when a patient inhales, air will pass through the blister and carry the drug into the airflow and deliver it through the mouthpiece 5 via a transfer cavity 23 located within the chamber and communicating with the mouthpiece. 5. By turning the knob 12, the clamping member 10 and the gasket 7 can be turned so that each blister is in turn placed under the piston.

30 De forskellige fremspring eller knaster 14 indgriber efter tur med udsparingen 15 for at sikre, at pakningen er placeret korrekt ud for stempelet.30 The various projections or knobs 14 in turn engage the recess 15 to ensure that the gasket is positioned correctly next to the piston.

Det er ikke afgørende, at stempelet har en kniv 21 til åbning af en blist. Der kan eventuelt benyttes en nål eller kanyle til perforering 35 af blisten, ligesom stempelet kan have en spids ende eller endog en stump ende, og et vilkårligt andet passende åbningsorgan kan benyttes.It is not essential that the piston has a knife 21 for opening a blister. Optionally, a needle or cannula may be used to perforate the blister, just as the plunger may have a pointed end or even a blunt end and any other suitable opening means may be used.

Mundstykkedækselet kan have en låsedel 24, der kan indgribe med stempelet, når apparatet ikke benyttes, for at forhindre tilfældig aktivering af stemplet.The nozzle cover may have a locking portion 24 which may engage the plunger when the apparatus is not in use to prevent accidental activation of the plunger.

DK 173079 B1 sDK 173079 B1 p

Under brug kan den patient, som behøver en medikamentdosis, holde apparatet med mundstykket i sin mund. Patienten trykker derefter stempelet ned for at åbne en blist og give adgang til medikamentet i samme og inhalerer gennem mundstykket, så at medikamentet bringes med 5 i luftstrømmen og føres ned i patientens lunger. Mundstykket kan eventuelt være forsynet med luftindløbsåbninger 25 til forøgelse af luftstrømmen, når patienten inhalerer.During use, the patient in need of a drug dose can hold the device with the mouthpiece in his mouth. The patient then depresses the plunger to open a blister and provide access to the drug in the same and inhales through the mouthpiece so that the drug is brought with 5 into the air stream and passed into the patient's lungs. The nozzle may optionally be provided with air inlet openings 25 for increasing the airflow as the patient inhales.

I en ikke vist modifikation kan blisterpakningens underside understøttes på en anden fastspændingsplade i stedet for af understøt-10 ningsranden eller skulderen 6.In a modification not shown, the underside of the blister pack may be supported on another clamping plate instead of the support rim or shoulder 6.

Pakningen er hensigtsmæssigt indrettet til at tilvejebringe et tilstrækkeligt antal individuelle doser til en patient til brug i løbet af en passende periode, såsom én eller flere dage. Huset kan være modificeret, idet det har et ekstra kammer, der ikke er synligt, i 15 bunden, idet dette ekstra kammer er lukket med et aftageligt dæksel 26. Dette ekstra kammer kan benyttes til lagring af ekstra blisterpakninger. Mundstykket kan eventuelt være således udformet, at det kan benyttes af en patient til inhalering gennem næsen.The package is suitably arranged to provide a sufficient number of individual doses to a patient for use over a suitable period, such as one or more days. The housing may be modified as it has an additional chamber which is not visible at the bottom, this additional chamber being closed with a removable cover 26. This additional chamber can be used for storing extra blister packs. The mouthpiece may optionally be designed so that it can be used by a patient for inhalation through the nose.

I fig. 3 og 4 er vist en modificeret udførelsesform for apparatet, der 20 ikke har nogen fastspændingsdel 10. Apparatet i denne modifikation har et hus 30 med et kammer 31. Et mundstykke 32 rager ud fra huset 30's cylindriske væg i en i alt væsentligt radial retning og står i forbindelse med kammeret 31's indre. En perforeret beskyttelsesplade 33 er placeret ved indgangen til mundstykket 32. En rand eller skulder 34 25 løber langs kammeret 31's indersidevæg til tilvejebringelse af en ringformet understøtning til en understøtningsdel 35, der har form af en cirkulær plade eller skive. Denne understøtningsdel er indrettet til at optage en blisterpakning 36. Pakningen 36 har flere beholdere 37, der kan brydes, og som er placeret i en cirkel. Disse beholdere 30 har form af blister med en i alt væsentlig konisk form, således som det klart fremgår af fig. 4, og indeholder et medikament som beskrevet under henvisning til fig. 1. Understøtningsdelen 35 har flere huller 38, hvis antal er lig med antallet af blister 37 i pakningen 36. Den koniske del af en blist 37 er placeret i hvert af hullerne 38, når 35 apparatet er fyldt og i brug. En udvendig drejelig del 39 med en riflet kant 40 er placeret med sin flade i kontakt med huset 30's bund. En tap 41 eller lignende og med radiale fremspring 42 strækker sig centralt fra understøtningsdelen 35 gennem et hul 43 i bunden af huset 30 og ind i en åbning 44 med komplementær form i en tap 45 på 40 delen 39. Tappen 45 passerer gennem hullet 43, og tappen 41 med fremspringene 42 indgriber 1 åbningen 44, så at drejning af delen 39 får understøtningsdelen 35 til at dreje tilsvarende. Et aftageligt DK 173079 B1 e dæksel 46 passer oven på huset 30. I dækselet 46 er der udformet en åbning 47, som indgriber med et fremspring 4Θ af huset 30 til korrekt lokalisering af dækselet. Dækselet 46 har en understøtning 49, på hvilken en arm eller aftrækker 50 er monteret drejeligt. Et stempel 51 5 er monteret på armen eller aftrækkeren 50 og strækker sig gennem et hul 52 i dækselet. Til lejring mellem aftrækkeren eller armen 50 og dækselet 46's overside findes en fjeder 53, som tvinger armen eller aftrækkeren opefter.In FIG. 3 and 4 are shown a modified embodiment of the apparatus having no clamping portion 10. The apparatus of this modification has a housing 30 with a chamber 31. A nozzle 32 protrudes from the cylindrical wall of the housing 30 in a substantially radial direction and communicates with the interior of chamber 31. A perforated protective plate 33 is located at the entrance to the mouthpiece 32. A rim or shoulder 34 25 runs along the inside wall of the chamber 31 to provide an annular support for a support member 35 in the form of a circular plate or disc. This support member is adapted to receive a blister pack 36. The pack 36 has several breakable containers 37 which are placed in a circle. These containers 30 are in the form of blisters having a substantially conical shape, as is clearly seen in FIG. 4, and contains a medicament as described with reference to FIG. 1. The support portion 35 has several holes 38, the number of which is equal to the number of blisters 37 in the pack 36. The tapered portion of a blister 37 is located in each of the holes 38 when the apparatus is filled and in use. An externally rotatable portion 39 with a ribbed edge 40 is positioned with its surface in contact with the bottom of housing 30. A pin 41 or the like and with radial projections 42 extends centrally from the support member 35 through a hole 43 at the bottom of the housing 30 and into an opening 44 of complementary shape in a pin 45 of the 40 member 39. The pin 45 passes through the hole 43, and the pin 41 with the projections 42 engages in the opening 44 so that rotation of the portion 39 causes the support portion 35 to rotate accordingly. A removable cover 46 fits on top of housing 30. In cover 46, an opening 47 is provided which engages with a projection 4Θ of housing 30 to properly locate the cover. The cover 46 has a support 49 on which an arm or trigger 50 is pivotally mounted. A piston 51 5 is mounted on the arm or trigger 50 and extends through a hole 52 in the cover. For bearing between the trigger or arm 50 and the upper side of the cover 46, a spring 53 is provided which forces the arm or trigger upwards.

Hullet 52 er placeret således, at hvert hul 38 i understøtningsdelen 10 35 ligger ud for hullet 52, når understøtningsdelen 35 drejes.The hole 52 is positioned so that each hole 38 in the support member 10 35 is aligned with the hole 52 as the support member 35 is rotated.

Når det ene af hullerne 38 er placeret ud for hullet 52, kan aftrækkeren 50 trykkes ned, så at stempelet 51, der kan have form af en nål, trænger gennem den blist 37, som er placeret i dette hul (dvs. perforerer toppen og bunden af blisten), hvorved pulveret kan afgives fra 15 blisten. En del af pulveret vil falde ned i en skuffelignende del 54 i kammeret 31. Når patienten inhalerer, passerer der luft gennem den perforerede blist, så at pulveret føres med i luftstrømmen og sammen med pulveret i delen 54 bliver trukket gennem beskyttelsespladen 33 og mundstykket 32. Når apparatet ikke er i brug kan mundstykket 32 20 indesluttes i et mundstykkedæksel eller en skede 55, der har en kanallignende forlængelse 56, som indgriber med understøtningen 49 for at forhindre, at stempelet 51 trykkes ned og føres gennem hullet 37.When one of the holes 38 is positioned next to the hole 52, the trigger 50 can be depressed so that the piston 51, which may be in the form of a needle, penetrates the blister 37 located in this hole (i.e., the top and the bottom of the blister), allowing the powder to be dispensed from the blister. A portion of the powder will fall into a drawer-like portion 54 of chamber 31. As the patient inhales, air passes through the perforated blister so that the powder is carried into the airflow and, together with the powder in the portion 54, is drawn through the protective plate 33 and the mouthpiece 32 When not in use, the nozzle 32 20 can be enclosed in a nozzle cover or sheath 55 having a channel-like extension 56 which engages with the support 49 to prevent the piston 51 from being pushed down and passed through the hole 37.

Når indretningen er i brug, og patienten inhalerer gennem mundstykket 32, er det naturligvis afgørende, at der kan passere luft ind i 25 kammeret 31's indre. Vilkårlige passende luftindløb kan være udformet.Of course, when the device is in use and the patient inhales through the mouthpiece 32, it is essential that air can pass into the interior of the chamber 31. Any suitable air inlet may be provided.

Det er imidlertid hensigtsmæssigt, at der kan passere luft gennem hullet 52, idet stempelet eller nålen 51 har en mindre diameter end diameteren af hullet 52, så at dette tjener som et luftindløb.However, it is convenient that air may pass through the hole 52, the piston or needle 51 having a smaller diameter than the diameter of the hole 52 so that it serves as an air inlet.

Fig. 5 viser et modificeret apparat, der passende kan benyttes til 30 administrering af to forskellige medikamenter til en patient på forskellige tidspunkter. Behandling af visse patienter kræver, at de inhalerer to forskellige typer medikamenter. I det i fig. 5 viste apparat har et fælles hus 57 to kamre, der svarer til kammeret 2 i den i fig. 1 og 2 viste udførelsesform eller til kammeret 31 i den i fig. 3 35 og 4 viste udførelsesform. Disse to kamre er lukket med aftagelige dæksler 58, og blisterpakninger, der er indeholdt i kamrene, kan drejes på de ovenfor beskrevne måder ved drejning af riflede hjul, knapper eller andre organer 59. Fra det fælles hus 57 strækker der sig udløbsmundstykker 60, idet hvert af disse udløb 60 fører ind i det ene 40 af de kamre, som indesluttes af det fælles hus. Aftrækkermekanismer 61 er monteret til at muliggøre, at blisterne i de blisterpakninger, som 7 DK 173079 B1 er indeholdt i kamrene, kan gennembores, så at indholdet i blisterne kan inhaleres af patienten.FIG. Figure 5 shows a modified apparatus which can be conveniently used for administering two different medications to a patient at different times. Treatment of certain patients requires them to inhale two different types of medication. In the embodiment of FIG. 5, a common housing 57 has two chambers corresponding to the chamber 2 in the embodiment of FIG. 1 and 2, or to the chamber 31 of the embodiment shown in FIG. 3 35 and 4. These two chambers are closed with removable covers 58, and blister packs contained in the chambers can be rotated in the ways described above by rotating knurled wheels, buttons or other means 59. Outlet nozzles 60 extend from the common housing 57, each of these outlets 60 leads into one of the 40 chambers enclosed by the common house. Extractor mechanisms 61 are mounted to enable the blisters in the blister packs contained in the chambers to be pierced so that the contents of the blisters can be inhaled by the patient.

Claims

A medicament package comprising a circular carrier disc (7, 36) having 5 multiple containers (8.37) formed integrally with the carrier disc and placed in a circle, each containing a dose of a medicament in finely divided form. , characterized in that the containers are arranged to be permeable on both sides of the carrier such that air can flow 10 through the container and receive the drug in the air stream.

Medicament pack according to claim 1, characterized in that the containers have a substantially conical shape.

Medicament pack according to claim 1 or 2, 15, characterized in that the carrier disc is of laminated foil material.