CA1055350A - Insufflator - Google Patents
InsufflatorInfo
- Publication number
- CA1055350A CA1055350A CA198,798A CA198798A CA1055350A CA 1055350 A CA1055350 A CA 1055350A CA 198798 A CA198798 A CA 198798A CA 1055350 A CA1055350 A CA 1055350A
- Authority
- CA
- Canada
- Prior art keywords
- rotor
- medicament
- housing
- capsule
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0098—Activated by exhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Abstract
INSUFFLATOR
ABSTRACT
This invention relates to an inhalation device for dispensing medicament having a rotor-driven medicament dispenser. A unitary mouthpiece for both inhalation and exhalation communicates with a housing divided into two chambers by a rotor. One chamber has an outlet valve and the other chamber has an inlet valve. One side of the rotor has vanes attached thereto. The other side of the rotor has dispenser means for a medicament. Exhalation through the mouth-piece and through the outlet valve causes the vanes and the rotor to rotate. This motion disperses the medicament into its chamber.
Inhalation through the inlet valve and mouthpiece causes inhalation of the medicament to the patient.
ABSTRACT
This invention relates to an inhalation device for dispensing medicament having a rotor-driven medicament dispenser. A unitary mouthpiece for both inhalation and exhalation communicates with a housing divided into two chambers by a rotor. One chamber has an outlet valve and the other chamber has an inlet valve. One side of the rotor has vanes attached thereto. The other side of the rotor has dispenser means for a medicament. Exhalation through the mouth-piece and through the outlet valve causes the vanes and the rotor to rotate. This motion disperses the medicament into its chamber.
Inhalation through the inlet valve and mouthpiece causes inhalation of the medicament to the patient.
Description
lOS5350 .. . .
SU~IMARY OF THE ~NVENTION . -Various insufflators have been proposed and used from which medicament can be inhaled directly into the lungs of a patient. These prior devices have generally relied upon the motion o the air being inhaled causing ~ ?
dispersion of the medicament into the air being inhaled.
Typical of such insufflators are devices described by Altounyan et al. in U.S. Patent Nos. 3,507,277 ~1970);
3,635;219 ~1972); and 3,669,113 ~1972).
lOIt has now been found that more reliable oPeration ~-of an insufflator can be obtained where the patient can `~
use the action of exhalation to distribute or disperse the medicament powder within a medicament chamber ready for reliable treatment upon inhalation drawing the dispersed powder from the chamber into the lungs of the patient.
According to the present invention there is provided an inhaling device for dispensing medicament in finely dlvided form comprising a housing, a rotor adapted to ..
~ . .
:
- . .. . . . . . ~ . :. ~ . . :
1~553so ~;
.:
disperse a medicament in a chamber within the housing, a mouthpiece communicating with the chamber, a passage communlcating between the chamber and the exterior of the housing, a drive portion of the rotor adapted to be driven by flow of air therepast, a second passage communicating the mouthpiece with the drive portion of the rotor, and ;
valve means permitting flow of air from the mouthpiece past said drive portion upon exhalation into the mouth-piece and alternatively permitting air flow through said first mentioned passage and said chamber upon inhalation through the mouthpiece.
Preferably the drive portion is provided in a - second chamber within the housing with the two chambers being separated by the rotor which may conveniently be in the form of a disk. The drive portion of the rotor ;
can then comprise a plurality of vanes adapted to be driven by an exhaled flow of air from the mouthpiece through the second chamber.
While the device may be constructed so as to provide on the rotor mounting means for a single capsule, prefer-ably so located as to extend radially outwards from the axis of the rotor so that when the outer end thereo-f is opened or pierced spinning of the rotor will help to dis-tribute medicament centrifugally within the medicament chamber, in an alternative arrangement a plurality of -~;
capsules may be mounted in a ring around the axis of the rotor with these capsules being usable in turn as ~
required by the patient. With this latter arrangement ~ ~ -conveniently the plurality of capsules may be mounted as part of a blister pack which is secured to a face of the rotor. It will be apparent that both capsule mounting arrangements provide means for effectively dispersing - lOSS~SO
medicament within the medicament chamber upon spinning of the rotor.
While it is possible for the capsules to be individ-ually opened or pierced as required by the patient before use by opening of the housing it is preferred that capsule opening means are provided selectively operable for breaking or piercing a capsule carried by the rotor. A
convenient form of capsule opening means may comprise a ~ ~
plunger manually movable between a rest position and the ~ -capsule opening position, the plunger being spring biased to a rest position. If a portion of the rotor iS
engageable from the outside o-E the housing for permitting indexing movement of the rotor within the housing, the rotor can readily be indexed to align a full capsule with the capsule opening means permitting the capsules in the insufflator to be prepared for use without any opening ;
of the housing by the patien~ being required. This is of particular convenience when the patient may require - ~
immediate relief, as all that he need do is take out the ` ~ :
loaded insufflator, open a capsule using the capsule .:. .
opening means, apply the mouthpiece to his mouth and quickly exhale before immediately inhaling to breath the ~;
dispersed particles of medicament into his lungs. .
A particularly convenient form of valve means com-prises nonreturn type flap valves covering ports through the housing, it being possible -for such flap valves to comprise simple flaps of resilient plastic material which I are normally in a position closing the ports associated f therewith.
f 30 BRIEF DESCRIPTION OF THE DRAWINGS
The i~vention will be further described, by way of example, with reference to the accompanying drawings, in which:
~L~553~
1 FIGURE 1 is a front elevational view of a single dose form of insufflator embodying the invention;
FIGURE 2 is a rear elevational view of the insuf-flator of Figure l;
FIGURE 3 is an end elevational view of the insuf-flator as viewed -from the right hand side of Figure l;
FIGURE 4 is a fragmentary sectional view taken through the front end cap of the insufflator and showing the inhalation nonreturn valve;
FIGURE 5 is a fragmentary sectional view taken through the rear end cap of the insufflator and showing the exhalation nonreturn valve; and FIGURE 6 to 8 are views similar to Figures l to 3 but showing a multiple dose form of the insufflator.
:.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
.
Referring to the drawings, and in particular to `~
Figures 1 to 3, there is shown a single dose inhalation device comprising a substantially cylindrical housing 1 of high impact thermosetting plastics material provided with front and rear end caps which, in the illustrated embodiment of the invention, are transparent. These end caps are screwed into position so as to be remo~able, and at least one of said end caps carries a bearing portion, not apparent in the drawings, for rotatably supporting a rotor 4 within the housing. The rotor is of disk like form and separates the chamber within the housing into a first chamber portion at the rear thereof and a second or medicament chamber portion at the front thereof. The rotor 4 comprises on the front side thereof a mounting 12 for a capsule or other suitable container 14 for accommodating ~J' ~ ~ ~ 53 a medicament to be dispensed, and on the rear side thereof is formed with a series of radial vanes 6 which, in a manner to be describecl below, acts as a drive por-tion for rotating the rotor. An inhalation passage or port 3 is provided through the end cap at the front of the housing, while an exhalation passage or port 5 is provided through the end cap at the rear o-f the housing. -A mouthpiece 2 has passage means which communicates with the interior o-f the housing and may comprise a divided entry providing a passage 11' leading to the aforementioned first chamber portion within the housing containing the ~ ;
vanes 6, and a passage 11 leading to the second or medi~
cament chamber portion within the housing within which , the rotor supports the medicament capsule 14. "
Manually operable capsule opening means 7 are shown ~
at the top of the housing as comprising a plunger 8 which ~ ;
is biased by a spring 9 to the rest position where an opening projection 10 is clear from contact with a cap-sule 14 carried by the rotor. The plunger 8 is manually ~ ;
depressable against the action of the spring 9 to cause the projection 10 to move towards the axis of the rotor whereby when a capsule 14 is aligned with the projection 10 such depression of the plunger will cause the projec-tion 10 to break or pierce the end of the capsule 14. ~ ;
Omitted in ~igures 1 and 2 are valve means in the form of nonreturn inhalation and exhalation valves 13 and 15 which cooperate with the ports 3 and 5, respectively.
These are shown in cross section in the detail views of Figures 4 and 5, the inhalation valve 13 being shown at the top of Figure 4 in the position closing the port 3 which it adopts at rest and when a patient is exha]ing through the mouthpiece 2 while the lower part of Pigure 4 ~ . . . -.. . .
1~553S0 shows the position adopted by the inhalation valve 13 when the patient is inhaling through the mouthpiece, air being sucked into the medicament chamber from the outside of the housing through the port 3. Similarly Figure 5 shows the exhalation valve 15 in its closed position which it occupies during rest and when the patient is inhaling through the mouthpiece and its open position which it occupies when the patient is exhaling through the mouthpiece.
In both instances the valves are simple nonreturn ~ , flap valves which are made of resilient plastic material ;
biased to closed position. The valve 13 is shown as mounted in a recess formed in an inner surface portion of the -front end cap of the housillg so that it does not project to a position where it could interfere with rota-tion of the rotor, while the valve 15 is shown as mounted on the outside of the rear end cap of the housing normally resiliently to close the port 5.
Figures 6 to 8 show an alternative embodiment of insufflator which is adapted to mount a plurality of cap-sules of medicament. The structure is generally similar ``
to that of Figures 1 to 3 with a housing 21 provided with a mouthpiece 22 and having in front and rear end caps, respectively, an inhalation port 23 and an exhalation port 25 provided with nonreturn flap valves similar to 'I those illustrated in Figures 4 and 5. A rotor 24 provided ¦ with vanes 26 on its rear side is mounted for rotation within the housing, the vanes being drivable by flow of air from the mouthpiece 22 through a first chamber portion 3~ containing the vanes and out through the exhalation port 25. On the front side of the disk like rotor a plurality of mounting means 32 are provided for capsules or other ;"
- .. .. ~ . ~ .. - -~ 55350 1 suitable containers 3~ for accommodating a medicament to be dispersed. The mounting means 32 are arranged to hold the capsules extending radially from the axis of the rotor, whereby upon rotation o~ the rotor a dispersion -of the medicament from a capsule will be assisted by centrifugal action, the outer end of the capsule being the part of the capsule opened.
In this embodiment no opening means corresponding `
with the opening means 7 of the first embodiment are illustrated although such may be provided if desired.
Instead, the user removes the front end cap of the housing in order manually to open a capsule before use of the insufflator, or he can use a piercing instrument to extend from the mouthpiece to penetrate the end of a capsule lS aligned with the mouthpiece passage 31.
As before, a portion of the rotor may be engageable exteriorly of the housing to permit indexing of a cap-sule for opening.
Instead of having individual mounting means for the various capsules they may be formed as a single blister pack which can be attached to the front face of the rotor 24.
In an alternative arrangement the rotor and medica-ment filled capsules may themselves comprise an entirely replaceable unit which can be provided within the housing for replacement by another full unit once all the individual doses have been used.
~uring use of the insufflator the patient, having loaded the device with one or more capsules, either opens one of the capsules manually be~ore replacing the end cover on the housing or utilizes an opening means 7 to .
~ ~ 5 5 3 S ~
l open the capsule after closure of the housing. The ~:
patient then puts the mouthpiece to his mouth and exhales strongly therethrough, whereupon the ai.r exhaled passes through the passage 11' or 30 into the -first chamber por~
tion within the housing flows past the vanes 6 or 26 and out through the exhalation port 5 or 25, causing the rotor - `
to spin at high speed to disperse medicament from the .
opened capsule into the medicament chamber portion within the housing. The patient then immediately inhales strongly through.the mouthpiece, wh.ereupon the ~alve 15 closes and the val~e 13 opens to permit air to be inhaled through inhalation port 3 or 23 and sai.d medicament chamber por~
tion, carrying with it medicament -from said chamber por~
tion lnto the Iungs of the patient, -8~ :
.', ~
,, , . . , ~ . . . .
SU~IMARY OF THE ~NVENTION . -Various insufflators have been proposed and used from which medicament can be inhaled directly into the lungs of a patient. These prior devices have generally relied upon the motion o the air being inhaled causing ~ ?
dispersion of the medicament into the air being inhaled.
Typical of such insufflators are devices described by Altounyan et al. in U.S. Patent Nos. 3,507,277 ~1970);
3,635;219 ~1972); and 3,669,113 ~1972).
lOIt has now been found that more reliable oPeration ~-of an insufflator can be obtained where the patient can `~
use the action of exhalation to distribute or disperse the medicament powder within a medicament chamber ready for reliable treatment upon inhalation drawing the dispersed powder from the chamber into the lungs of the patient.
According to the present invention there is provided an inhaling device for dispensing medicament in finely dlvided form comprising a housing, a rotor adapted to ..
~ . .
:
- . .. . . . . . ~ . :. ~ . . :
1~553so ~;
.:
disperse a medicament in a chamber within the housing, a mouthpiece communicating with the chamber, a passage communlcating between the chamber and the exterior of the housing, a drive portion of the rotor adapted to be driven by flow of air therepast, a second passage communicating the mouthpiece with the drive portion of the rotor, and ;
valve means permitting flow of air from the mouthpiece past said drive portion upon exhalation into the mouth-piece and alternatively permitting air flow through said first mentioned passage and said chamber upon inhalation through the mouthpiece.
Preferably the drive portion is provided in a - second chamber within the housing with the two chambers being separated by the rotor which may conveniently be in the form of a disk. The drive portion of the rotor ;
can then comprise a plurality of vanes adapted to be driven by an exhaled flow of air from the mouthpiece through the second chamber.
While the device may be constructed so as to provide on the rotor mounting means for a single capsule, prefer-ably so located as to extend radially outwards from the axis of the rotor so that when the outer end thereo-f is opened or pierced spinning of the rotor will help to dis-tribute medicament centrifugally within the medicament chamber, in an alternative arrangement a plurality of -~;
capsules may be mounted in a ring around the axis of the rotor with these capsules being usable in turn as ~
required by the patient. With this latter arrangement ~ ~ -conveniently the plurality of capsules may be mounted as part of a blister pack which is secured to a face of the rotor. It will be apparent that both capsule mounting arrangements provide means for effectively dispersing - lOSS~SO
medicament within the medicament chamber upon spinning of the rotor.
While it is possible for the capsules to be individ-ually opened or pierced as required by the patient before use by opening of the housing it is preferred that capsule opening means are provided selectively operable for breaking or piercing a capsule carried by the rotor. A
convenient form of capsule opening means may comprise a ~ ~
plunger manually movable between a rest position and the ~ -capsule opening position, the plunger being spring biased to a rest position. If a portion of the rotor iS
engageable from the outside o-E the housing for permitting indexing movement of the rotor within the housing, the rotor can readily be indexed to align a full capsule with the capsule opening means permitting the capsules in the insufflator to be prepared for use without any opening ;
of the housing by the patien~ being required. This is of particular convenience when the patient may require - ~
immediate relief, as all that he need do is take out the ` ~ :
loaded insufflator, open a capsule using the capsule .:. .
opening means, apply the mouthpiece to his mouth and quickly exhale before immediately inhaling to breath the ~;
dispersed particles of medicament into his lungs. .
A particularly convenient form of valve means com-prises nonreturn type flap valves covering ports through the housing, it being possible -for such flap valves to comprise simple flaps of resilient plastic material which I are normally in a position closing the ports associated f therewith.
f 30 BRIEF DESCRIPTION OF THE DRAWINGS
The i~vention will be further described, by way of example, with reference to the accompanying drawings, in which:
~L~553~
1 FIGURE 1 is a front elevational view of a single dose form of insufflator embodying the invention;
FIGURE 2 is a rear elevational view of the insuf-flator of Figure l;
FIGURE 3 is an end elevational view of the insuf-flator as viewed -from the right hand side of Figure l;
FIGURE 4 is a fragmentary sectional view taken through the front end cap of the insufflator and showing the inhalation nonreturn valve;
FIGURE 5 is a fragmentary sectional view taken through the rear end cap of the insufflator and showing the exhalation nonreturn valve; and FIGURE 6 to 8 are views similar to Figures l to 3 but showing a multiple dose form of the insufflator.
:.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
.
Referring to the drawings, and in particular to `~
Figures 1 to 3, there is shown a single dose inhalation device comprising a substantially cylindrical housing 1 of high impact thermosetting plastics material provided with front and rear end caps which, in the illustrated embodiment of the invention, are transparent. These end caps are screwed into position so as to be remo~able, and at least one of said end caps carries a bearing portion, not apparent in the drawings, for rotatably supporting a rotor 4 within the housing. The rotor is of disk like form and separates the chamber within the housing into a first chamber portion at the rear thereof and a second or medicament chamber portion at the front thereof. The rotor 4 comprises on the front side thereof a mounting 12 for a capsule or other suitable container 14 for accommodating ~J' ~ ~ ~ 53 a medicament to be dispensed, and on the rear side thereof is formed with a series of radial vanes 6 which, in a manner to be describecl below, acts as a drive por-tion for rotating the rotor. An inhalation passage or port 3 is provided through the end cap at the front of the housing, while an exhalation passage or port 5 is provided through the end cap at the rear o-f the housing. -A mouthpiece 2 has passage means which communicates with the interior o-f the housing and may comprise a divided entry providing a passage 11' leading to the aforementioned first chamber portion within the housing containing the ~ ;
vanes 6, and a passage 11 leading to the second or medi~
cament chamber portion within the housing within which , the rotor supports the medicament capsule 14. "
Manually operable capsule opening means 7 are shown ~
at the top of the housing as comprising a plunger 8 which ~ ;
is biased by a spring 9 to the rest position where an opening projection 10 is clear from contact with a cap-sule 14 carried by the rotor. The plunger 8 is manually ~ ;
depressable against the action of the spring 9 to cause the projection 10 to move towards the axis of the rotor whereby when a capsule 14 is aligned with the projection 10 such depression of the plunger will cause the projec-tion 10 to break or pierce the end of the capsule 14. ~ ;
Omitted in ~igures 1 and 2 are valve means in the form of nonreturn inhalation and exhalation valves 13 and 15 which cooperate with the ports 3 and 5, respectively.
These are shown in cross section in the detail views of Figures 4 and 5, the inhalation valve 13 being shown at the top of Figure 4 in the position closing the port 3 which it adopts at rest and when a patient is exha]ing through the mouthpiece 2 while the lower part of Pigure 4 ~ . . . -.. . .
1~553S0 shows the position adopted by the inhalation valve 13 when the patient is inhaling through the mouthpiece, air being sucked into the medicament chamber from the outside of the housing through the port 3. Similarly Figure 5 shows the exhalation valve 15 in its closed position which it occupies during rest and when the patient is inhaling through the mouthpiece and its open position which it occupies when the patient is exhaling through the mouthpiece.
In both instances the valves are simple nonreturn ~ , flap valves which are made of resilient plastic material ;
biased to closed position. The valve 13 is shown as mounted in a recess formed in an inner surface portion of the -front end cap of the housillg so that it does not project to a position where it could interfere with rota-tion of the rotor, while the valve 15 is shown as mounted on the outside of the rear end cap of the housing normally resiliently to close the port 5.
Figures 6 to 8 show an alternative embodiment of insufflator which is adapted to mount a plurality of cap-sules of medicament. The structure is generally similar ``
to that of Figures 1 to 3 with a housing 21 provided with a mouthpiece 22 and having in front and rear end caps, respectively, an inhalation port 23 and an exhalation port 25 provided with nonreturn flap valves similar to 'I those illustrated in Figures 4 and 5. A rotor 24 provided ¦ with vanes 26 on its rear side is mounted for rotation within the housing, the vanes being drivable by flow of air from the mouthpiece 22 through a first chamber portion 3~ containing the vanes and out through the exhalation port 25. On the front side of the disk like rotor a plurality of mounting means 32 are provided for capsules or other ;"
- .. .. ~ . ~ .. - -~ 55350 1 suitable containers 3~ for accommodating a medicament to be dispersed. The mounting means 32 are arranged to hold the capsules extending radially from the axis of the rotor, whereby upon rotation o~ the rotor a dispersion -of the medicament from a capsule will be assisted by centrifugal action, the outer end of the capsule being the part of the capsule opened.
In this embodiment no opening means corresponding `
with the opening means 7 of the first embodiment are illustrated although such may be provided if desired.
Instead, the user removes the front end cap of the housing in order manually to open a capsule before use of the insufflator, or he can use a piercing instrument to extend from the mouthpiece to penetrate the end of a capsule lS aligned with the mouthpiece passage 31.
As before, a portion of the rotor may be engageable exteriorly of the housing to permit indexing of a cap-sule for opening.
Instead of having individual mounting means for the various capsules they may be formed as a single blister pack which can be attached to the front face of the rotor 24.
In an alternative arrangement the rotor and medica-ment filled capsules may themselves comprise an entirely replaceable unit which can be provided within the housing for replacement by another full unit once all the individual doses have been used.
~uring use of the insufflator the patient, having loaded the device with one or more capsules, either opens one of the capsules manually be~ore replacing the end cover on the housing or utilizes an opening means 7 to .
~ ~ 5 5 3 S ~
l open the capsule after closure of the housing. The ~:
patient then puts the mouthpiece to his mouth and exhales strongly therethrough, whereupon the ai.r exhaled passes through the passage 11' or 30 into the -first chamber por~
tion within the housing flows past the vanes 6 or 26 and out through the exhalation port 5 or 25, causing the rotor - `
to spin at high speed to disperse medicament from the .
opened capsule into the medicament chamber portion within the housing. The patient then immediately inhales strongly through.the mouthpiece, wh.ereupon the ~alve 15 closes and the val~e 13 opens to permit air to be inhaled through inhalation port 3 or 23 and sai.d medicament chamber por~
tion, carrying with it medicament -from said chamber por~
tion lnto the Iungs of the patient, -8~ :
.', ~
,, , . . , ~ . . . .
Claims (9)
1. In a device for the inhalation of powdered medicament having a housing, a mouthpiece, a rotor, means for opening a capsule of medicament and means for dispersing the medicament in response to rotation of the rotor, the improvement comprising:
a first chamber portion and a medicament chamber portion in the housing respectively defined by one side of the rotor which carries a plurality of radial vanes to drive the rotor in response to air flow and by the other side of the rotor which carries one or more means for mounting medicament in capsule form;
air passage means in the mouthpiece respectively com-municating with the first chamber portion and with the medicament chamber portion of the housing;
an air exhaust port communicating with the first chamber portion and an air inlet port communicating with the medica-ment chamber portion; and first one-way valve means for enabling airflow through the first chamber portion and the exhaust port by exhalation through the mouthpiece and a second one-way valve means for enabling airflow through the inlet port and the medicament chamber to effect entrainment of the medicament by inhalation through the mouthpiece.
a first chamber portion and a medicament chamber portion in the housing respectively defined by one side of the rotor which carries a plurality of radial vanes to drive the rotor in response to air flow and by the other side of the rotor which carries one or more means for mounting medicament in capsule form;
air passage means in the mouthpiece respectively com-municating with the first chamber portion and with the medicament chamber portion of the housing;
an air exhaust port communicating with the first chamber portion and an air inlet port communicating with the medica-ment chamber portion; and first one-way valve means for enabling airflow through the first chamber portion and the exhaust port by exhalation through the mouthpiece and a second one-way valve means for enabling airflow through the inlet port and the medicament chamber to effect entrainment of the medicament by inhalation through the mouthpiece.
2. A device according to Claim 1 wherein said dispersing means comprises means on said rotor for mounting a plurality of capsules of medicament in spaced relation about the axis of said rotor.
3. Apparatus according to Claim 2 wherein said dispersing means comprises a replaceable unitary multiple capsule pack mounted on said rotor.
4. Apparatus according to Claim 2 wherein a plurality of capsules of medicament are mounted on said rotor and form therewith a replaceable unit.
5. A device according to Claim 1 wherein the capsule opening means comprises a plunger manually movable between a rest position and an operative position in which it is adapted to penetrate a capsule carried by said rotor.
6. A device according to Claim 5 wherein said plunger is spring biased toward its rest position.
7. Apparatus according to Claim 1 wherein said one-way valves are normally closed flap valves.
8. Apparatus according to Claim 1 wherein said air passage communicating with the first chamber is positioned to direct exhaled air at the drive portion of said rotor in a manner tending to cause rotation thereof.
9. A device according to Claim 1 wherein a portion of the rotor is engageable from outside of the housing for permitting indexing movement of the rotor within the housing.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2199173A GB1387954A (en) | 1973-05-08 | 1973-05-08 | Insufflator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1055350A true CA1055350A (en) | 1979-05-29 |
Family
ID=10172161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA198,798A Expired CA1055350A (en) | 1973-05-08 | 1974-05-03 | Insufflator |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3870046A (en) |
| JP (1) | JPS5048788A (en) |
| AR (1) | AR198921A1 (en) |
| CA (1) | CA1055350A (en) |
| CH (1) | CH564950A5 (en) |
| DE (1) | DE2421761C3 (en) |
| ES (1) | ES426030A1 (en) |
| FR (1) | FR2228499A1 (en) |
| GB (1) | GB1387954A (en) |
| IL (1) | IL44695A (en) |
| NL (1) | NL7406119A (en) |
| NO (1) | NO133923C (en) |
| SE (1) | SE409547B (en) |
| ZA (1) | ZA742561B (en) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2346914C3 (en) * | 1973-09-18 | 1980-10-16 | Paul Ritzau Pari-Werk, Gmbh & Co, 8130 Starnberg | Powdered substance inhaler |
| SE408265B (en) * | 1975-12-12 | 1979-06-05 | Draco Ab | DEVICE FOR CARBON DIOXIDE POWERED ENDOSAEROSOL, INTENDED FOR INHALATION |
| SE395611B (en) * | 1975-12-12 | 1977-08-22 | Draco Ab | AEROSOL INHALATION DEVICE INTENDED FOR INHALATION THROUGH AN INHALATION MOUTH OF PHARMACOLOGICALLY ACTIVE SUBSTANCES |
| ES506585A0 (en) * | 1980-10-30 | 1982-09-01 | Riker Laboratories Inc | A DEVICE TO FACILITATE THE ORAL INHALATION OF MEDICINES IN THE FORM OF POWDER |
| GB2169265B (en) * | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
| ZA837318B (en) * | 1982-10-08 | 1985-06-26 | Glaxo Group Ltd | Device for administering medicaments to patients |
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| EP1993645A4 (en) * | 2006-03-03 | 2011-05-18 | Stc Unm | Dry powder inhaler with aeroelastic dispersion mechanism |
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| CA2779488A1 (en) | 2009-11-12 | 2011-05-19 | Stc.Unm | Dry powder inhaler with flutter dispersion member |
| ES2646748T3 (en) | 2010-12-07 | 2017-12-15 | Respira Therapeutics, Inc. | Dry powder inhaler |
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| US10463815B2 (en) | 2012-02-21 | 2019-11-05 | Respira Therapeutics, Inc. | Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents |
| CN107427650A (en) | 2015-01-14 | 2017-12-01 | 瑞必治公司 | Powder process for dispersing and device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1599959A (en) * | 1923-03-23 | 1926-09-14 | Fujimoto Buheiji | Atomizer |
| US2573918A (en) * | 1949-11-05 | 1951-11-06 | Vick Chemical Company | Device for dispensing medicaments |
| GB1268051A (en) * | 1968-06-07 | 1972-03-22 | Fisons Pharmaceuticals Ltd | Inhalation device |
| IT941426B (en) * | 1971-07-17 | 1973-03-01 | Isf Spa | SWIRL-CHAMBER INHALER FOR POWDER-SHAPING MEDICINAL SUBSTANCES |
| US3777742A (en) * | 1972-09-18 | 1973-12-11 | Barber Colman Co | Tantalum insufflator |
-
1973
- 1973-05-08 GB GB2199173A patent/GB1387954A/en not_active Expired
-
1974
- 1974-04-22 US US462805A patent/US3870046A/en not_active Expired - Lifetime
- 1974-04-23 IL IL44695A patent/IL44695A/en unknown
- 1974-04-23 ZA ZA00742561A patent/ZA742561B/en unknown
- 1974-05-03 CA CA198,798A patent/CA1055350A/en not_active Expired
- 1974-05-06 NO NO741629A patent/NO133923C/no unknown
- 1974-05-06 DE DE2421761A patent/DE2421761C3/en not_active Expired
- 1974-05-07 ES ES426030A patent/ES426030A1/en not_active Expired
- 1974-05-07 FR FR7415728A patent/FR2228499A1/fr not_active Withdrawn
- 1974-05-07 SE SE7406121A patent/SE409547B/en unknown
- 1974-05-07 AR AR253617A patent/AR198921A1/en active
- 1974-05-07 CH CH623074A patent/CH564950A5/xx not_active IP Right Cessation
- 1974-05-07 JP JP49049827A patent/JPS5048788A/ja active Pending
- 1974-05-07 NL NL7406119A patent/NL7406119A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU6818374A (en) | 1975-10-23 |
| CH564950A5 (en) | 1975-08-15 |
| SE409547B (en) | 1979-08-27 |
| IL44695A0 (en) | 1974-06-30 |
| ZA742561B (en) | 1975-04-30 |
| ES426030A1 (en) | 1976-07-01 |
| NL7406119A (en) | 1974-11-12 |
| GB1387954A (en) | 1975-03-19 |
| US3870046A (en) | 1975-03-11 |
| NO133923B (en) | 1976-04-12 |
| IL44695A (en) | 1977-01-31 |
| DE2421761A1 (en) | 1974-11-21 |
| DE2421761B2 (en) | 1977-08-18 |
| JPS5048788A (en) | 1975-05-01 |
| DE2421761C3 (en) | 1978-04-13 |
| NO133923C (en) | 1976-07-21 |
| AR198921A1 (en) | 1974-07-24 |
| FR2228499A1 (en) | 1974-12-06 |
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