GB2264237A - An inhaler - Google Patents

An inhaler Download PDF

Info

Publication number
GB2264237A
GB2264237A GB9202469A GB9202469A GB2264237A GB 2264237 A GB2264237 A GB 2264237A GB 9202469 A GB9202469 A GB 9202469A GB 9202469 A GB9202469 A GB 9202469A GB 2264237 A GB2264237 A GB 2264237A
Authority
GB
United Kingdom
Prior art keywords
magazine
device
dose
cap
mouthpiece
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9202469A
Other versions
GB9202469D0 (en
Inventor
Robert Edward Newell
Original Assignee
Robert Edward Newell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Edward Newell filed Critical Robert Edward Newell
Priority to GB9202469A priority Critical patent/GB2264237A/en
Publication of GB9202469D0 publication Critical patent/GB9202469D0/en
Publication of GB2264237A publication Critical patent/GB2264237A/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043Non-destructive separation of the package, e.g. peeling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007Mechanical counters
    • A61M15/0071Mechanical counters having a display or indicator
    • A61M15/0075Mechanical counters having a display or indicator on a disc

Abstract

A powder inhaler for use in the treatment of medical problems of the air passages, lungs or bronchial conditions, such as bronchial asthma comprises an openable casing 3 having a mouthpiece and containing a replaceable magazine disc 1, 2 provided with a plurality of recesses or cups, each holding a dose of powder and being individually closed by a discrete closure element which can be opened and then reclosed. The disc may be indexed around to present a closed cap adjacent a projection 16 at the mouthpiece and then moved in the casing transverse to its rotational axis so that the projection removes the closure element. A ring (15, Fig 4) is provided in the top casing portion to assist reclosure of the closure element after inhalation. <IMAGE>

Description

TITLE A magazined device for inhalation of powdered medication to and by patients.

GENERAL BACKGROUND Devices and systems exist whereby powder for inhalation is enclosed in a gelatine or metal capsule and each capsule is loaded into the device individually each time treatment is required. The capsule is usually broken, cut, pierced, or parted by the device prior to treatment.

Problems can arise with the said capsulese.g. the gelatine or metal breaking into particles which- may be inhaled by the patient. Also, gelatine being relatively unstable and fragile, aluminium, also being delicate, both require further packaging for protection to avoid environmental degradation of the product. Also by the very nature of gelatine source a stability problem may also arise.

TECHNICAL FEATURES According to the present invention there is provided a plastic or metal disc with a plurality of holes or recesses, or cups, around the periphery of the disc. Each hole or recess contains one dose of the medicament. Ideally, there would be sufficient dosage for one week to one month's treatment, but it can be less or more. Each dose is capped off or sealed off to protect the product and maintain product security. The capped circular disc, also known as a magazine is thenplaced in a dispensing device which enables the doses of powder to be used individually as required by the patient. A specific embodiment will now be described by way of example and with reference to the accompanying drawings: FIGURE (1) Shows in perspective the device with the circular disc 1 showing the recesses or cups to hold the medicament and the individual caps 2 joined at the centre.The case 3 which holds the filled and capped disc (magazine).

The cap 4 which covers the mouthpiece and relocates the capped disc.

The spring 5 which locates each dose when the disc is rotated.

FIGURE (2) Illustrates rear end view of device 7.

Shows sketch of mouthpiece operation opening cap from powdered dose 8 cup or recess.

FIGURE (3) Shows the device assembled 9.

Illustrates the cap removed 10.

Referring to the drawing as figure (1), this shows a circular plastic disc with the plurality of holes, cups or recesses each to hold a dose of powder to the exclusion of air 1. Each dose is closed by the caps shown as 2. The closed disc is then located into recess 11 located by pivot 12. The plastic spring 5 is then located in position in the base of the case and preferably located at the first dose to be used. The top of the case is then closed, sealing in the medicament magazine prior to use.

Also shown is the slot in top 13 and bottom 14 of case, which allows magazine containing the doses to be moved forward and vack prior and after inhalation. Also shown is the cap 4 which is included to keep mouthpiece clean and to return dose disc after use. It should be noted that the dose disc and caps are collectively known as the magazine. The magazine is rotated by hand to the next dose prior to inhalation. The magazine is pushed forward by hand, the action of which removes the cap from the required dose. This is shown on Figure (2), as is also the principle by which the powder is inhaled by a venturi effect by the patient. Also shown is a weakness to the hinge 8 to facilitate removal of the cap from the medicament dose container.

5 shows the plastic spring which provides a click stop for each dose when the magazine is rotated. The dose numbers are either embossed or printed on the magazine to ideally decrease when rotated, e.g. 100, 99, 98 etc. This will show how many doses are left. In order to rotate the dose magazine it is shown in Figure (3). the magazine protrudes from the case 3 on both sides enabling the dose magazine to be pushed forward when required. Or rotated as required.

FIGURE (4) Illustrates alternative cup shapes -18 which hold required doses.

19 and 20 demonstrate cap on cup principle.

15 indicates ring to be clipped into top of case 3 to assist in closing of cap onto cup after inhalation.

Claims (10)

1. A device for administering medicaments in solid finely divided powder form to patients, comprising a magazine containing a plurality of medicament doses each dose individually closed, and an actuating case with mouthpiece to hold magazine.
2. A device according to claim 1. whereby the magazine disc is of a circular shape, individual doses being situated around the periphery of said magazine as 1. and 2. on Figure (1).
3. The magazine is rotatable mounted within case 3 being indexed to the next dose.
4. The magazine is movable in a longitudinal position to open cap against mouthpiece protrudcence 16 for required dose 8.
5. The magazine is movable in a longitudinal position to close cap, reverse of claim 4.
6. A device whereby the required dose in magazine is locked in position by plastic spring 5 on Figure (2).
7. A device whereby the magazine when located within the device is rotatable within the device 10 on Figure (3).
8. A device whereby the cap can be replaced on the device and the dose magazine is moved back by the cap 17 into its original position.
9. A device whereby the shape of the dose cup or recess is influential in promoting a venturi effect 18. Figure (4) shows shape varience.
10..A device whereby a circular separate or integral moulding 15 is included in moulding to assist closing of dose cap.
GB9202469A 1992-02-05 1992-02-05 An inhaler Withdrawn GB2264237A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9202469A GB2264237A (en) 1992-02-05 1992-02-05 An inhaler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9202469A GB2264237A (en) 1992-02-05 1992-02-05 An inhaler

Publications (2)

Publication Number Publication Date
GB9202469D0 GB9202469D0 (en) 1992-03-18
GB2264237A true GB2264237A (en) 1993-08-25

Family

ID=10709893

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9202469A Withdrawn GB2264237A (en) 1992-02-05 1992-02-05 An inhaler

Country Status (1)

Country Link
GB (1) GB2264237A (en)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004827A1 (en) * 1995-07-25 1997-02-13 Sarnoff Corporation Inhaler apparatus using a tribo-electric charging technique
WO1997025086A2 (en) * 1996-01-03 1997-07-17 Glaxo Group Limited Inhalation device
WO1998010817A1 (en) * 1996-09-12 1998-03-19 Alfred Von Schuckmann Inhaler device
WO1998030263A1 (en) * 1997-01-09 1998-07-16 Sepracor, Inc. Multiple-dose dispenser for dry powder inhalers
EP1009461A1 (en) * 1997-03-20 2000-06-21 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
EP1166812A1 (en) * 2000-06-28 2002-01-02 Microdose Technologies Inc. Packaging and delivery of pharmaceuticals and drugs
EP1172122A1 (en) * 2000-07-14 2002-01-16 The Technology Partnership Public Limited Company Dry powder inhaler
WO2002000280A3 (en) * 2000-06-23 2002-05-02 Ivax Corp Pre-metered dose magazine for breath-actuated dry powder inhaler
US6415790B1 (en) 1997-09-18 2002-07-09 Delsys Pharmaceutical Corporation Dry powder delivery system apparatus
EP1283731A2 (en) * 2000-05-10 2003-02-19 Innovative Devices, LLC Medicament container with same side airflow inlet and outlet and method of use
WO2003015857A1 (en) * 2001-08-16 2003-02-27 Meridica Limited Pack containing medicament and dispensing device
WO2003051439A1 (en) * 2001-12-14 2003-06-26 Technology Innovation Limited Medicament packaging and dispenser
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
WO2004045487A2 (en) * 2002-11-20 2004-06-03 Sun Pharmaceutical Industries Limited Dry powder inhaler
EP1427465A1 (en) * 2001-09-19 2004-06-16 Advent Pharmaceuticals Pyt Ltd An inhaler
US7562769B2 (en) 2003-03-15 2009-07-21 Brintech International Limited Formulation and presentation of medicaments
US20100192949A1 (en) * 2009-01-30 2010-08-05 Vectura Delivery Devices Limited Inhaler
US7931022B2 (en) 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
US7987845B2 (en) 2006-01-31 2011-08-02 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
US8151793B2 (en) 2007-12-20 2012-04-10 Astrazeneca Ab Device and method for deaggregating powder
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US9211383B2 (en) 2009-07-01 2015-12-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
US9289564B2 (en) 2005-04-15 2016-03-22 Vectura Delivery Devices Limited Blister piercing element for dry powder inhaler
US10034989B2 (en) 2013-01-23 2018-07-31 Vectura Delivery Devices Limited Blister piercing element for a dry powder inhaler

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1387954A (en) * 1973-05-08 1975-03-19 Miles Lab Insufflator
GB1562732A (en) * 1976-02-10 1980-03-12 Allen & Hanburys Ltd Device for dispensing medicaments
WO1982001470A1 (en) * 1980-10-30 1982-05-13 Baum Eric A Powder inhalation device
GB2129691A (en) * 1982-10-08 1984-05-23 Glaxo Group Ltd Devices for administering medicaments to patients
GB2178965A (en) * 1985-07-30 1987-02-25 Glaxo Group Ltd Devices for administering medicaments to patients
GB2246299A (en) * 1990-06-08 1992-01-29 Glaxo Group Ltd Medicament-containing article and device therefor.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1387954A (en) * 1973-05-08 1975-03-19 Miles Lab Insufflator
GB1562732A (en) * 1976-02-10 1980-03-12 Allen & Hanburys Ltd Device for dispensing medicaments
WO1982001470A1 (en) * 1980-10-30 1982-05-13 Baum Eric A Powder inhalation device
GB2129691A (en) * 1982-10-08 1984-05-23 Glaxo Group Ltd Devices for administering medicaments to patients
GB2178965A (en) * 1985-07-30 1987-02-25 Glaxo Group Ltd Devices for administering medicaments to patients
GB2246299A (en) * 1990-06-08 1992-01-29 Glaxo Group Ltd Medicament-containing article and device therefor.

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6729324B2 (en) 1995-06-08 2004-05-04 Innovative Devices, Llc. Inhalation actuated device for use with metered dose inhalers (MDIs)
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
US5642727A (en) * 1995-07-25 1997-07-01 David Sarnoff Research Center, Inc. Inhaler apparatus using a tribo-electric charging technique
WO1997004827A1 (en) * 1995-07-25 1997-02-13 Sarnoff Corporation Inhaler apparatus using a tribo-electric charging technique
WO1997025086A2 (en) * 1996-01-03 1997-07-17 Glaxo Group Limited Inhalation device
WO1997025086A3 (en) * 1996-01-03 1997-09-04 Glaxo Group Ltd Inhalation device
US6065472A (en) * 1996-01-03 2000-05-23 Glaxo Wellcome Inc. Multidose powder inhalation device
WO1998010817A1 (en) * 1996-09-12 1998-03-19 Alfred Von Schuckmann Inhaler device
WO1998030263A1 (en) * 1997-01-09 1998-07-16 Sepracor, Inc. Multiple-dose dispenser for dry powder inhalers
US5794613A (en) * 1997-01-09 1998-08-18 Sepracor, Inc. Multiple-dose dispenser for dry powder inhalers
EP1009461A1 (en) * 1997-03-20 2000-06-21 Dura Pharmaceuticals, Inc. Dry powder inhaler
EP1009461A4 (en) * 1997-03-20 2001-01-03 Dura Pharma Inc Dry powder inhaler
US6273085B1 (en) 1997-03-20 2001-08-14 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6415790B1 (en) 1997-09-18 2002-07-09 Delsys Pharmaceutical Corporation Dry powder delivery system apparatus
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
US7318436B2 (en) 2000-05-10 2008-01-15 Innovative Devices, Llc Medicament container with same side airflow inlet and outlet and method of use
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
JP2004508072A (en) * 2000-05-10 2004-03-18 イノベーティブ・ディバイシィーズ・エルエルシー Drug reservoir with an inlet and outlet of the air flow in the same side, as well as how to use the container
EP1283731A2 (en) * 2000-05-10 2003-02-19 Innovative Devices, LLC Medicament container with same side airflow inlet and outlet and method of use
JP4754758B2 (en) * 2000-05-10 2011-08-24 イノベーティブ・ディバイシィーズ・エルエルシー Drug container with air flow inlet and outlet on the same side
EP1283731A4 (en) * 2000-05-10 2004-06-23 Innovative Devices Llc Medicament container with same side airflow inlet and outlet and method of use
US6655381B2 (en) 2000-06-23 2003-12-02 Ivax Corporation Pre-metered dose magazine for breath-actuated dry powder inhaler
GB2372215A (en) * 2000-06-23 2002-08-21 Norton Healthcare Ltd Pre-metered dose magazine for breath-actuated dry powder inhaler
WO2002000280A3 (en) * 2000-06-23 2002-05-02 Ivax Corp Pre-metered dose magazine for breath-actuated dry powder inhaler
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US8573202B2 (en) 2000-06-28 2013-11-05 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
EP1166812A1 (en) * 2000-06-28 2002-01-02 Microdose Technologies Inc. Packaging and delivery of pharmaceuticals and drugs
US7950390B2 (en) 2000-06-28 2011-05-31 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US7810495B2 (en) 2000-06-28 2010-10-12 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
WO2002005881A1 (en) * 2000-07-14 2002-01-24 The Technology Partnership Plc Dry powder inhaler
EP1172122A1 (en) * 2000-07-14 2002-01-16 The Technology Partnership Public Limited Company Dry powder inhaler
US7987985B2 (en) 2001-08-16 2011-08-02 Pfizer Limited Pack containing medicament and dispensing device
WO2003015857A1 (en) * 2001-08-16 2003-02-27 Meridica Limited Pack containing medicament and dispensing device
US7401713B2 (en) 2001-08-16 2008-07-22 Meridica Limited Pack containing medicament and dispensing device
CN1951356B (en) 2001-08-16 2010-05-19 麦瑞迪卡有限公司 Pack containing medicament and dispensing device
EP1427465A4 (en) * 2001-09-19 2012-01-25 Advent Pharmaceuticals Pty Ltd An inhaler
EP1427465A1 (en) * 2001-09-19 2004-06-16 Advent Pharmaceuticals Pyt Ltd An inhaler
US7931022B2 (en) 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
WO2003051439A1 (en) * 2001-12-14 2003-06-26 Technology Innovation Limited Medicament packaging and dispenser
US7249600B2 (en) 2001-12-14 2007-07-31 Technology Innovation Limited Medicament packaging and dispenser
WO2004045487A3 (en) * 2002-11-20 2005-01-27 Sun Pharmaceutical Ind Ltd Dry powder inhaler
WO2004045487A2 (en) * 2002-11-20 2004-06-03 Sun Pharmaceutical Industries Limited Dry powder inhaler
US7562769B2 (en) 2003-03-15 2009-07-21 Brintech International Limited Formulation and presentation of medicaments
US9289564B2 (en) 2005-04-15 2016-03-22 Vectura Delivery Devices Limited Blister piercing element for dry powder inhaler
US8375941B2 (en) 2006-01-31 2013-02-19 Oriel Therapeutics, Inc. Methods of operating dry powder inhalers having spiral travel paths with microcartridges of dry powder
US7987845B2 (en) 2006-01-31 2011-08-02 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
US9283337B2 (en) 2007-12-20 2016-03-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
US8151793B2 (en) 2007-12-20 2012-04-10 Astrazeneca Ab Device and method for deaggregating powder
US8479729B2 (en) 2007-12-20 2013-07-09 Astrazeneca Ab Device and method for deaggregating powder
US8578933B2 (en) 2007-12-20 2013-11-12 Astrazeneca Ab Entraining powder in an airflow
US8522776B2 (en) * 2009-01-30 2013-09-03 Vectura Delivery Devices Limited Inhaler
US20100192949A1 (en) * 2009-01-30 2010-08-05 Vectura Delivery Devices Limited Inhaler
US8739785B2 (en) 2009-01-30 2014-06-03 Vectura Delivery Devices Limited Inhaler
US9211383B2 (en) 2009-07-01 2015-12-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US9974909B2 (en) 2010-01-05 2018-05-22 Microdose Therapeutx, Inc. Inhalation device and method
US10034989B2 (en) 2013-01-23 2018-07-31 Vectura Delivery Devices Limited Blister piercing element for a dry powder inhaler

Also Published As

Publication number Publication date
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Legal Events

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)