GB1594314A - Medicine for the treatment of acne - Google Patents
Medicine for the treatment of acne Download PDFInfo
- Publication number
- GB1594314A GB1594314A GB286878A GB286878A GB1594314A GB 1594314 A GB1594314 A GB 1594314A GB 286878 A GB286878 A GB 286878A GB 286878 A GB286878 A GB 286878A GB 1594314 A GB1594314 A GB 1594314A
- Authority
- GB
- United Kingdom
- Prior art keywords
- medicinal composition
- weight
- composition according
- erythromycin
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010000496 acne Diseases 0.000 title description 13
- 208000002874 Acne Vulgaris Diseases 0.000 title description 12
- 239000003814 drug Substances 0.000 title description 10
- 229940079593 drug Drugs 0.000 title description 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 90
- 229960003276 erythromycin Drugs 0.000 claims description 45
- 239000000203 mixture Substances 0.000 claims description 38
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 30
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 30
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 30
- 229930002330 retinoic acid Natural products 0.000 claims description 27
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 26
- 239000000499 gel Substances 0.000 claims description 26
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 22
- 239000006210 lotion Substances 0.000 claims description 20
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000002674 ointment Substances 0.000 claims description 12
- 230000001476 alcoholic effect Effects 0.000 claims description 11
- 235000019441 ethanol Nutrition 0.000 claims description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- 150000002009 diols Chemical class 0.000 claims description 9
- 239000006071 cream Substances 0.000 claims description 6
- 150000005215 alkyl ethers Chemical class 0.000 claims description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 5
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 235000019155 vitamin A Nutrition 0.000 description 4
- 239000011719 vitamin A Substances 0.000 description 4
- 229940045997 vitamin a Drugs 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- -1 propylene glycol Chemical class 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 206010051814 Eschar Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- DDSWXKKQCZQLDN-UHFFFAOYSA-N [Na].[Na].CC(=O)ON.CC(=O)ON.CC(=O)OCCOC(C)=O Chemical compound [Na].[Na].CC(=O)ON.CC(=O)ON.CC(=O)OCCOC(C)=O DDSWXKKQCZQLDN-UHFFFAOYSA-N 0.000 description 1
- 230000002333 acnegenic effect Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003377 anti-microbal effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000531 effect on virus Effects 0.000 description 1
- 231100000333 eschar Toxicity 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000051 modifying effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 150000003138 primary alcohols Chemical group 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/38—Percompounds, e.g. peracids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7702157A FR2378523A1 (fr) | 1977-01-26 | 1977-01-26 | Medicament pour le traitement de l'acne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1594314A true GB1594314A (en) | 1981-07-30 |
Family
ID=9185920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB286878A Expired GB1594314A (en) | 1977-01-26 | 1978-01-24 | Medicine for the treatment of acne |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE876157Q (enrdf_load_stackoverflow) |
| DE (1) | DE2802924C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2378523A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1594314A (enrdf_load_stackoverflow) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2191483A (en) * | 1986-05-06 | 1987-12-16 | Oreal | New retinoic acid esters of antibiotics |
| US4954487A (en) * | 1979-01-08 | 1990-09-04 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| US5445823A (en) * | 1994-10-20 | 1995-08-29 | The Procter & Gamble Company | Dermatological compositions and method of treatment of skin lesions therewith |
| US5733886A (en) * | 1992-02-18 | 1998-03-31 | Lloyd J. Baroody | Compositions of clindamycin and benzoyl peroxide for acne treatment |
| US5767098A (en) * | 1985-12-12 | 1998-06-16 | Dermik Laboratories, Inc. | Anti-acne method and composition |
| US6013637A (en) * | 1998-06-12 | 2000-01-11 | Dermik Laboratories Inc. | Anti-acne method and composition |
| JP2005513146A (ja) * | 2001-12-21 | 2005-05-12 | ガルデルマ・リサーチ・アンド・デヴェロップメント・エス・エヌ・セ | 少なくとも一つのレチノイド及び過酸化ベンゾイルを含むゲル組成物 |
| US20080176954A1 (en) * | 2001-12-21 | 2008-07-24 | Galderma Research & Development, S.N.C. | Dermatological/cosmetic gels comprising at least one retinoid and benzoyl peroxide |
| EP2214661A4 (en) * | 2007-10-18 | 2012-10-03 | Medicis Pharmaceutical Corp | AQUEOUS RETINOID AND DIBENZOYL PEROXIDE GEL |
| US8663699B2 (en) | 2008-06-05 | 2014-03-04 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US9107844B2 (en) | 2006-02-03 | 2015-08-18 | Stiefel Laboratories Inc. | Topical skin treating compositions |
| US10925814B2 (en) | 2006-12-21 | 2021-02-23 | Galderma Research & Development | Cream gels comprising at least one retinoid and benzoyl peroxide |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA795492B (en) * | 1978-10-20 | 1981-05-27 | Lilly Co Eli | Stable erythromycin solution |
| EP0013459A3 (en) * | 1979-01-08 | 1981-05-13 | THE PROCTER & GAMBLE COMPANY | Topical anti-acne compositions |
| US4505896A (en) * | 1979-04-19 | 1985-03-19 | Elorac, Ltd. | Method of treating acne vulgaris and composition |
| GB2068228B (en) * | 1980-01-24 | 1984-02-29 | Janssen Pharmaceutica Nv | Anti-microbial compositions for the topical treatment of acne vulgaris |
| IT1210608B (it) * | 1980-12-08 | 1989-09-14 | Rorer Int Overseas | Composizione per il trattamento topico dell'acne |
| EP0109102B1 (en) * | 1982-10-15 | 1988-01-20 | THE PROCTER & GAMBLE COMPANY | Storage stable topical pharmaceutical composition including nitrogen-containing stabilizers |
| ZA837627B (en) * | 1982-10-15 | 1984-06-27 | Procter & Gamble | Storage stable topical pharmaceutical composition containing low dielectric solvents |
| FR2558372B1 (fr) * | 1984-01-25 | 1987-08-07 | Oreal | Composition medicamenteuse pour le traitement de l'acne |
| LU86393A1 (fr) * | 1986-04-16 | 1987-12-07 | Oreal | Composition anti-acneique stable a base d'erythromycine |
| FR2623395B1 (fr) * | 1987-11-24 | 1990-04-20 | Oreal | Compositions pharmaceutiques et cosmetiques a base de peroxyde de benzoyle et de salicylates lipophiles d'ammonium quaternaires et leur utilisation, notamment dans le traitement de l'acne |
| FR2628319B1 (fr) * | 1988-03-09 | 1990-12-07 | Oreal | Compositions pharmaceutiques et cosmetiques a base de peroxyde de benzoyle et de sels d'ammonium quaternaires |
| ES2043093T3 (es) * | 1988-06-13 | 1993-12-16 | Paul Herzog | Composicion para uso cosmetico o farmaceutico. |
| EP0536360A4 (en) * | 1991-03-05 | 1993-08-04 | Bloom, Leonard | Topical treatment of acne |
| US5466446A (en) * | 1994-02-16 | 1995-11-14 | Stiefel Laboratories, Inc. | Topical compositions containing bensoyl peroxide and clindamycin and method of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA945068A (en) * | 1967-10-25 | 1974-04-09 | Albert M. Kligman | Composition and method of treating acne |
| GB1525120A (en) * | 1974-12-19 | 1978-09-20 | Nelson Res & Dev | Topical antimicrobial compositions |
| CA1090253A (en) * | 1976-11-01 | 1980-11-25 | Edward D. Thompson | Anti-acne composition |
-
1977
- 1977-01-26 FR FR7702157A patent/FR2378523A1/fr active Granted
-
1978
- 1978-01-24 GB GB286878A patent/GB1594314A/en not_active Expired
- 1978-01-24 DE DE19782802924 patent/DE2802924C2/de not_active Expired
-
1979
- 1979-05-10 BE BE195080A patent/BE876157Q/xx active
Cited By (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954487A (en) * | 1979-01-08 | 1990-09-04 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| US5767098A (en) * | 1985-12-12 | 1998-06-16 | Dermik Laboratories, Inc. | Anti-acne method and composition |
| GB2191483A (en) * | 1986-05-06 | 1987-12-16 | Oreal | New retinoic acid esters of antibiotics |
| GB2191483B (en) * | 1986-05-06 | 1990-05-30 | Oreal | New retinoic acid esters of antibiotics , process for the preparation thereof and pharmaceutical and cosmetic compositions containing them |
| US5733886A (en) * | 1992-02-18 | 1998-03-31 | Lloyd J. Baroody | Compositions of clindamycin and benzoyl peroxide for acne treatment |
| US5445823A (en) * | 1994-10-20 | 1995-08-29 | The Procter & Gamble Company | Dermatological compositions and method of treatment of skin lesions therewith |
| US6013637A (en) * | 1998-06-12 | 2000-01-11 | Dermik Laboratories Inc. | Anti-acne method and composition |
| US8105618B2 (en) | 2001-12-21 | 2012-01-31 | Galderma Research & Development | Dermatological/cosmetic gels comprising at least one retinoid and/or retinoid salt and benzoyl peroxide |
| JP2005513146A (ja) * | 2001-12-21 | 2005-05-12 | ガルデルマ・リサーチ・アンド・デヴェロップメント・エス・エヌ・セ | 少なくとも一つのレチノイド及び過酸化ベンゾイルを含むゲル組成物 |
| RU2320327C2 (ru) * | 2001-12-21 | 2008-03-27 | Галдерма Ресерч Энд Девелопмент, Снс | Гель, содержащий по меньшей мере один ретиноид и пероксид бензоила |
| US20080176954A1 (en) * | 2001-12-21 | 2008-07-24 | Galderma Research & Development, S.N.C. | Dermatological/cosmetic gels comprising at least one retinoid and benzoyl peroxide |
| US7820186B2 (en) | 2001-12-21 | 2010-10-26 | Galderma Research & Development | Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| KR101014586B1 (ko) * | 2001-12-21 | 2011-02-16 | 갈데르마 리써어치 앤드 디벨로프먼트 | 하나 이상의 레티노이드 및 벤조일 퍼옥시드를 포함하는 겔 |
| US7964202B2 (en) | 2001-12-21 | 2011-06-21 | Galderma Research & Development, S.N.C. | Method for treatment of common acne |
| US9814690B2 (en) | 2001-12-21 | 2017-11-14 | Galderma Research & Development | Gel composition for treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| US8241649B2 (en) | 2001-12-21 | 2012-08-14 | Galderma Research & Development | Dermatological/cosmetic gels comprising at least one retinoid and/or retinoid salt and benzoyl peroxide |
| US8936800B2 (en) | 2001-12-21 | 2015-01-20 | Galderma Research & Development | Gel composition for treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| CN1329025C (zh) * | 2001-12-21 | 2007-08-01 | 盖尔德马研究及发展公司 | 包含至少一种类维生素a和过氧化苯甲酰的凝胶 |
| US9107844B2 (en) | 2006-02-03 | 2015-08-18 | Stiefel Laboratories Inc. | Topical skin treating compositions |
| US10925814B2 (en) | 2006-12-21 | 2021-02-23 | Galderma Research & Development | Cream gels comprising at least one retinoid and benzoyl peroxide |
| EP2214661A4 (en) * | 2007-10-18 | 2012-10-03 | Medicis Pharmaceutical Corp | AQUEOUS RETINOID AND DIBENZOYL PEROXIDE GEL |
| US8895070B2 (en) | 2008-06-05 | 2014-11-25 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US9504704B2 (en) | 2008-06-05 | 2016-11-29 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US9561208B2 (en) | 2008-06-05 | 2017-02-07 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US9078870B2 (en) | 2008-06-05 | 2015-07-14 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US10137142B2 (en) | 2008-06-05 | 2018-11-27 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US10220049B2 (en) | 2008-06-05 | 2019-03-05 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US10624918B2 (en) | 2008-06-05 | 2020-04-21 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US8663699B2 (en) | 2008-06-05 | 2014-03-04 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
| US11478498B2 (en) | 2008-06-05 | 2022-10-25 | Dow Pharmaceutical Sciences, Inc. | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2378523B1 (enrdf_load_stackoverflow) | 1982-11-05 |
| BE876157Q (fr) | 1979-09-03 |
| DE2802924C2 (de) | 1989-08-10 |
| DE2802924A1 (de) | 1978-07-27 |
| FR2378523A1 (fr) | 1978-08-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19960124 |