GB1533235A - Benzodiazepine derivatives - Google Patents
Benzodiazepine derivativesInfo
- Publication number
- GB1533235A GB1533235A GB51240/74A GB5124074A GB1533235A GB 1533235 A GB1533235 A GB 1533235A GB 51240/74 A GB51240/74 A GB 51240/74A GB 5124074 A GB5124074 A GB 5124074A GB 1533235 A GB1533235 A GB 1533235A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzodiazepine derivatives
- benzodiazepine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (42)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU742191705A SU629879A3 (ru) | 1974-11-26 | 1974-11-25 | Способ получени тиено(1,5) бензодиазепинов или их солей |
GB51240/74A GB1533235A (en) | 1974-11-26 | 1974-11-26 | Benzodiazepine derivatives |
IL48502A IL48502A (en) | 1974-11-26 | 1975-11-20 | Tthieno(1,5)benzodiazepine derivatives their preparation and pharmaceutical compositions containing them |
CA240,082A CA1075687A (en) | 1974-11-26 | 1975-11-20 | Benzodiazepine derivatives |
IL54634A IL54634A (en) | 1974-11-26 | 1975-11-20 | Thieno (1,5) benzodiazepine derivatives |
DK524175A DK146887C (da) | 1974-11-26 | 1975-11-20 | Analogifremgangsmaade til fremstilling af thieno(1,5)benzodiazepinderivater |
AU86858/75A AU506340B2 (en) | 1974-11-26 | 1975-11-21 | Benzodiazepine derivatives |
PH17788A PH11669A (en) | 1974-11-26 | 1975-11-21 | Thienobenzo(1,5)diazepine derivatives and the pharmaceutical formulation thereof |
DE2552403A DE2552403C2 (de) | 1974-11-26 | 1975-11-22 | Thieno[1,5]-benzodiazepine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel |
CH604478A CH613455A5 (en) | 1974-11-26 | 1975-11-24 | Process for the preparation of new benzodiazepine derivatives |
SE7513185A SE421209B (sv) | 1974-11-26 | 1975-11-24 | Analogiforfarande for framstellning av tienobensodiazepiner |
NZ185594A NZ185594A (en) | 1974-11-26 | 1975-11-24 | 10-substituted-4h-thieno-(2,3-b),(3,2-b) or (3,4-b-(1,5) benzodiazepines |
CH1517275A CH613454A5 (en) | 1974-11-26 | 1975-11-24 | Process for the preparation of new benzodiazepine derivatives |
NZ179335A NZ179335A (en) | 1974-11-26 | 1975-11-24 | 10-substituted aminothieno(2,3-b,3,2-b or 3,4-b)(1,5)benzodiazepines |
ZA757344A ZA757344B (en) | 1974-11-26 | 1975-11-24 | Benzodiazepine derivatives |
IE2565/75A IE42564B1 (en) | 1974-11-26 | 1975-11-25 | Benzodiazepine derivatives |
DD189666A DD123343A5 (enrdf_load_stackoverflow) | 1974-11-26 | 1975-11-25 | |
JP50141080A JPS6044314B2 (ja) | 1974-11-26 | 1975-11-25 | チエノ〔1.5〕ベンゾジアゼピンの製法 |
IE1607/79A IE42565B1 (en) | 1974-11-26 | 1975-11-25 | Thieno (1,5) benzodiazepine intermediates |
FR7535900A FR2292479A1 (fr) | 1974-11-26 | 1975-11-25 | Derives de benzodiazepine |
RO7584018A RO69912A (ro) | 1974-11-26 | 1975-11-25 | Procedeu pentru prepararea unor tieno (1,5) benzodiazepine |
BE6045266A BE835932A (fr) | 1974-11-26 | 1975-11-25 | Derives de benzodiazepine |
YU02983/75A YU298375A (en) | 1974-11-26 | 1975-11-25 | Process for obtaining benzodiazepine derivatives |
AR261340A AR221203A1 (es) | 1974-11-26 | 1975-11-25 | Un compuesto intermediario sin actividad terapeutica que consiste en un derivado de la tieno(4,5)benzodiazepina,y un procedimiento para preparar una tieno-(1,5)benzodiazepina partiendo de dicho intermediario |
PL1975184991A PL100135B1 (pl) | 1974-11-26 | 1975-11-26 | Sposob wytwarzania nowych pochodnych tieno/1,5/benzodwuazepiny |
BG031601A BG29573A3 (en) | 1974-11-26 | 1975-11-26 | Method of obtaining of benzodiazepin derivatives |
NLAANVRAGE7513833,A NL186088C (nl) | 1974-11-26 | 1975-11-26 | Werkwijze ter bereiding van een geneesmiddel met werking op het centrale zenuwstelsel dat als werkzame stof ten minste een derivaat van een amino-thienobenzo-n-heterozevenringverbinding bevat, en werkwijze voor de bereiding van deze werkzame stof. |
AT898275A AT351547B (de) | 1974-11-26 | 1975-11-26 | Verfahren zur herstellung von neuen thieno- (1,5)-benzodiazepinen und deren saeure- additionssalzen |
CS757991A CS236753B2 (en) | 1974-11-26 | 1975-11-26 | Processing of thieno (1,5) benzodiazepine derivatives |
ES443011A ES443011A1 (es) | 1974-11-26 | 1975-11-26 | Un procedimiento de preparacion de una tieno (1,5)-benzodia-zepina. |
HU75LI00000284A HU172493B (hu) | 1974-11-26 | 1975-11-26 | Sposob poluchenija proizvodnykh tienobenzodiazepina |
SU762406250A SU626702A3 (ru) | 1974-11-26 | 1976-10-07 | Способ получени тиено (1,5) бензодиазепинов или их солей |
PH19480A PH24534A (en) | 1974-11-26 | 1977-02-22 | Benzothieno(1,5)diazepine intermediates |
US05/787,189 US4172831A (en) | 1974-11-26 | 1977-04-13 | Thieno-benzodiazepines |
US05/787,197 US4115568A (en) | 1974-11-26 | 1977-04-13 | Thieno[3,2-b]-[1,5]benzodiazepines |
US05/802,381 US4115574A (en) | 1974-11-26 | 1977-06-01 | Benzodiazepine derivatives |
SE7812194A SE429045B (sv) | 1974-11-26 | 1978-11-27 | Mellanprodukt for anvendning vid framstellning av tienobensodiazepiner |
DK375479A DK147020C (da) | 1974-11-26 | 1979-09-07 | Thieno(1,5)benzodiazepinforbindelser til anvendelse som mellemprodukter |
KE3163A KE3163A (en) | 1974-11-26 | 1981-09-24 | Benzodiazepine derivatives |
HK586/81A HK58681A (en) | 1974-11-26 | 1981-11-26 | Benzodiazepine derivatives |
YU123482A YU123482A (en) | 1974-11-26 | 1982-06-09 | Process for obtaining benzodiazepine derivatives |
MY149/82A MY8200149A (en) | 1974-11-26 | 1982-12-30 | Benzodiazepine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB51240/74A GB1533235A (en) | 1974-11-26 | 1974-11-26 | Benzodiazepine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1533235A true GB1533235A (en) | 1978-11-22 |
Family
ID=10459213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB51240/74A Expired GB1533235A (en) | 1974-11-26 | 1974-11-26 | Benzodiazepine derivatives |
Country Status (30)
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0354781A3 (en) * | 1988-08-11 | 1991-04-03 | Lilly Industries Limited | Benzodiazepine compounds and their use as pharmaceuticals |
EP0454436A1 (en) * | 1990-04-25 | 1991-10-30 | Lilly Industries Limited | Pharmaceutical compounds |
AU668159B2 (en) * | 1992-05-29 | 1996-04-26 | Lilly Industries Limited | Pharmaceutical compounds |
EP1016664A4 (en) * | 1997-09-02 | 2001-01-24 | Yoshitomi Pharmaceutical | CONDENSED THIOPHENE COMPOUNDS AND THEIR USE IN MEDICINE |
RU2185383C1 (ru) * | 2001-05-22 | 2002-07-20 | Институт молекулярной генетики РАН | ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН |
WO2004000847A1 (en) * | 2002-06-20 | 2003-12-31 | Adamed Sp. Z O.O. | A process for the preparation of olanzapine and an intermediate therefor |
WO2004006933A2 (en) | 2002-07-15 | 2004-01-22 | Krka, D.D., Novo Mesto | Crystal forms of olanzapine and processes for their preparation |
WO2004065390A1 (en) * | 2003-01-17 | 2004-08-05 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of olanzapine |
WO2005070939A1 (en) * | 2004-01-27 | 2005-08-04 | Synthon B.V. | Synthesis of olanzapine and intermediates thereof |
WO2005090359A2 (en) | 2004-03-18 | 2005-09-29 | Lek Pharmaceuticals D.D. | Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2, 3-b][1,5]benzodiazepine and salts thereof |
WO2011009831A1 (en) | 2009-07-20 | 2011-01-27 | Lek Pharmaceuticals D.D. | Process for the purification of olanzapine |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL62792A (en) * | 1980-05-07 | 1985-02-28 | Byk Gulden Lomberg Chem Fab | Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them |
WO1997016430A1 (en) * | 1995-11-01 | 1997-05-09 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
WO2006004931A2 (en) * | 2004-06-30 | 2006-01-12 | Athersys, Inc. | Substituted azepine derivatives as serotonin receptor modulators |
-
1974
- 1974-11-25 SU SU742191705A patent/SU629879A3/ru active
- 1974-11-26 GB GB51240/74A patent/GB1533235A/en not_active Expired
-
1975
- 1975-11-20 CA CA240,082A patent/CA1075687A/en not_active Expired
- 1975-11-20 IL IL48502A patent/IL48502A/xx unknown
- 1975-11-20 DK DK524175A patent/DK146887C/da active
- 1975-11-21 AU AU86858/75A patent/AU506340B2/en not_active Expired
- 1975-11-21 PH PH17788A patent/PH11669A/en unknown
- 1975-11-22 DE DE2552403A patent/DE2552403C2/de not_active Expired
- 1975-11-24 NZ NZ179335A patent/NZ179335A/xx unknown
- 1975-11-24 SE SE7513185A patent/SE421209B/xx not_active IP Right Cessation
- 1975-11-24 CH CH604478A patent/CH613455A5/xx not_active IP Right Cessation
- 1975-11-24 CH CH1517275A patent/CH613454A5/xx not_active IP Right Cessation
- 1975-11-24 ZA ZA757344A patent/ZA757344B/xx unknown
- 1975-11-25 IE IE2565/75A patent/IE42564B1/en unknown
- 1975-11-25 AR AR261340A patent/AR221203A1/es active
- 1975-11-25 BE BE6045266A patent/BE835932A/xx not_active IP Right Cessation
- 1975-11-25 DD DD189666A patent/DD123343A5/xx unknown
- 1975-11-25 FR FR7535900A patent/FR2292479A1/fr active Granted
- 1975-11-25 JP JP50141080A patent/JPS6044314B2/ja not_active Expired
- 1975-11-25 YU YU02983/75A patent/YU298375A/xx unknown
- 1975-11-25 RO RO7584018A patent/RO69912A/ro unknown
- 1975-11-26 BG BG031601A patent/BG29573A3/xx unknown
- 1975-11-26 HU HU75LI00000284A patent/HU172493B/hu unknown
- 1975-11-26 ES ES443011A patent/ES443011A1/es not_active Expired
- 1975-11-26 NL NLAANVRAGE7513833,A patent/NL186088C/xx not_active IP Right Cessation
- 1975-11-26 PL PL1975184991A patent/PL100135B1/pl unknown
- 1975-11-26 AT AT898275A patent/AT351547B/de not_active IP Right Cessation
- 1975-11-26 CS CS757991A patent/CS236753B2/cs unknown
-
1976
- 1976-10-07 SU SU762406250A patent/SU626702A3/ru active
-
1977
- 1977-02-22 PH PH19480A patent/PH24534A/en unknown
-
1978
- 1978-11-27 SE SE7812194A patent/SE429045B/sv not_active IP Right Cessation
-
1981
- 1981-09-24 KE KE3163A patent/KE3163A/xx unknown
- 1981-11-26 HK HK586/81A patent/HK58681A/xx unknown
-
1982
- 1982-12-30 MY MY149/82A patent/MY8200149A/xx unknown
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0354781A3 (en) * | 1988-08-11 | 1991-04-03 | Lilly Industries Limited | Benzodiazepine compounds and their use as pharmaceuticals |
EP0454436A1 (en) * | 1990-04-25 | 1991-10-30 | Lilly Industries Limited | Pharmaceutical compounds |
AU668159B2 (en) * | 1992-05-29 | 1996-04-26 | Lilly Industries Limited | Pharmaceutical compounds |
RU2125574C1 (ru) * | 1992-05-29 | 1999-01-27 | Лилли Индастриз Лимитед | Тиенобензодиазепины или их фармацевтически приемлемые соли, способ их получения и фармацевтическая композиция |
US6455521B1 (en) | 1997-09-02 | 2002-09-24 | Mitsubishi Pharma Corporation | Condensed thiophene compounds and pharmaceutical use thereof |
EP1016664A4 (en) * | 1997-09-02 | 2001-01-24 | Yoshitomi Pharmaceutical | CONDENSED THIOPHENE COMPOUNDS AND THEIR USE IN MEDICINE |
US6271225B1 (en) | 1997-09-02 | 2001-08-07 | Welfide Corporation | Fused thiophene compounds and medicinal use thereof |
RU2185383C1 (ru) * | 2001-05-22 | 2002-07-20 | Институт молекулярной генетики РАН | ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН |
WO2004000847A1 (en) * | 2002-06-20 | 2003-12-31 | Adamed Sp. Z O.O. | A process for the preparation of olanzapine and an intermediate therefor |
EP1669359A1 (en) * | 2002-06-20 | 2006-06-14 | Adamed SP. Z O.O. | A process for the preparation of olanzapine and an intermediate therefor |
HRP20041075B1 (hr) * | 2002-06-20 | 2008-05-31 | Adamed Sp.Z.O.O. | Postupak priprave olanzapina i njegovog intermedijera |
CN100338069C (zh) * | 2002-06-20 | 2007-09-19 | 阿达梅德公司 | 制备奥氮平及其中间体的方法 |
WO2004006933A2 (en) | 2002-07-15 | 2004-01-22 | Krka, D.D., Novo Mesto | Crystal forms of olanzapine and processes for their preparation |
WO2004065390A1 (en) * | 2003-01-17 | 2004-08-05 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of olanzapine |
EA007950B1 (ru) * | 2003-01-17 | 2007-02-27 | Крка, Товарна Здравил, Д.Д., Ново Место | Способ и промежуточные соединения для получения оланзапина |
DE10301923B3 (de) * | 2003-01-17 | 2004-09-16 | Krka Tovarna Zdravil, D.D. | Verfahren und Zwischenprodukte zur Herstellung von Olanzapin |
US7498433B2 (en) | 2003-01-17 | 2009-03-03 | Krka, Tovarna Zdravil, D.D. | Process and intermediates for the preparation of olanzapine |
WO2005070939A1 (en) * | 2004-01-27 | 2005-08-04 | Synthon B.V. | Synthesis of olanzapine and intermediates thereof |
WO2005090359A2 (en) | 2004-03-18 | 2005-09-29 | Lek Pharmaceuticals D.D. | Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2, 3-b][1,5]benzodiazepine and salts thereof |
WO2011009831A1 (en) | 2009-07-20 | 2011-01-27 | Lek Pharmaceuticals D.D. | Process for the purification of olanzapine |
EP2292624A1 (en) | 2009-07-20 | 2011-03-09 | LEK Pharmaceuticals d.d. | Process for the purification of olanzapine |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH11652A (en) | Arloxphenylpropylamines derivatives | |
ZA755418B (en) | Diazepine derivatives | |
IL46341A (en) | -aryl-4-substituted piperidino-alkanol derivatives | |
KE3163A (en) | Benzodiazepine derivatives | |
PH12312A (en) | Thienothiazine derivatives | |
GB1519811A (en) | Thienothaiazine derivatives | |
AU1038176A (en) | 4-arylpiperidine derivatives | |
AU7921975A (en) | Hexahydro-alpha-carboline derivatives | |
GB1521320A (en) | Quinolisidine derivatives | |
ZA753315B (en) | Oxacyclohexane derivatives | |
AU502405B2 (en) | Benzodiazepine derivatives | |
ZA751899B (en) | Benzo-bicyclononene derivatives | |
ZA753299B (en) | Amidino-hydrazone derivatives | |
ZA751280B (en) | Benzodiazepines | |
GB1486646A (en) | Thieno-pyridine derivatives | |
JPS51115457A (en) | 166methyll9 alphaa halosteroid derivatives | |
AU499054B2 (en) | Benzodiazepine derivatives | |
GB1482503A (en) | Benzodiazepine derivatives | |
KE3004A (en) | Benzodiazepine derivatives | |
ZA751281B (en) | Benzodiazepines | |
ZA753363B (en) | Benzazine derivatives | |
HK28879A (en) | 2-aminomethylphenol derivatives | |
ZA752916B (en) | Benzodiazepines | |
HK43378A (en) | Hexahydrodibenzofuran-3-one derivatives | |
AU490569B2 (en) | Benzodiazepine derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 19951123 |