GB1508042A - Dihydroxycalciferols - Google Patents
DihydroxycalciferolsInfo
- Publication number
- GB1508042A GB1508042A GB24138/75A GB2413875A GB1508042A GB 1508042 A GB1508042 A GB 1508042A GB 24138/75 A GB24138/75 A GB 24138/75A GB 2413875 A GB2413875 A GB 2413875A GB 1508042 A GB1508042 A GB 1508042A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- groups
- isomers
- formula
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000006239 protecting group Chemical group 0.000 abstract 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 235000012239 silicon dioxide Nutrition 0.000 abstract 2
- 239000000377 silicon dioxide Substances 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000000746 allylic group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 229910052709 silver Inorganic materials 0.000 abstract 1
- 239000004332 silver Substances 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6866474A JPS539222B2 (en, 2012) | 1974-06-18 | 1974-06-18 | |
JP14133174A JPS5320989B2 (en, 2012) | 1974-12-09 | 1974-12-09 | |
JP14132974A JPS5168556A (en) | 1974-12-09 | 1974-12-09 | 1 arufua 244 jihidorokishikorekarushifuerooruno seizohoho |
JP49141332A JPS5168560A (en) | 1974-12-09 | 1974-12-09 | 1 arufua 244 jihidorokishikorekarushifuerooruno bunriho |
JP14133074A JPS5168557A (en) | 1974-12-09 | 1974-12-09 | 1 arufua 244 jihidorokishikorekarushifuerooruno seizoho |
JP14902074A JPS5176254A (en) | 1974-12-27 | 1974-12-27 | 1 arufua * 24 * s * jihidorokishikorekarushifueroorunoseizoho |
JP14901874A JPS5176253A (en) | 1974-12-27 | 1974-12-27 | 1 arufua *24 * r * jihidorokishikorekarushifueroorunoseizohoho |
JP14901774A JPS5176252A (en) | 1974-12-27 | 1974-12-27 | 1 arufua *24 * r * jihidorokishikorekarushifueroorunoseizoho |
JP14902174A JPS5176255A (en) | 1974-12-27 | 1974-12-27 | 1 arufua * 24 * s * jihidorokishikorekarushifueroorunoseizohoho |
JP14902274A JPS5176259A (en) | 1974-12-27 | 1974-12-27 | 244 benzoiruokishikoresuteroorujudotaino 24 iepimaanobunriho |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1508042A true GB1508042A (en) | 1978-04-19 |
Family
ID=27580092
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB24138/75A Expired GB1508042A (en) | 1974-06-18 | 1975-06-04 | Dihydroxycalciferols |
GB44013/76A Expired GB1508043A (en) | 1974-06-18 | 1975-06-04 | Trihydroxycholesta-5,7-dienes |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB44013/76A Expired GB1508043A (en) | 1974-06-18 | 1975-06-04 | Trihydroxycholesta-5,7-dienes |
Country Status (10)
Country | Link |
---|---|
US (1) | US4022891A (en, 2012) |
CA (1) | CA1051442A (en, 2012) |
CH (1) | CH618669A5 (en, 2012) |
DE (1) | DE2526981C3 (en, 2012) |
DK (1) | DK142410B (en, 2012) |
FR (1) | FR2275196A1 (en, 2012) |
GB (2) | GB1508042A (en, 2012) |
NL (1) | NL7507268A (en, 2012) |
NO (1) | NO145162C (en, 2012) |
SE (1) | SE413096B (en, 2012) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1088094B (it) * | 1976-10-14 | 1985-06-04 | Hoffmann La Roche | Derivati del pregnano |
JPS53147051A (en) * | 1977-05-24 | 1978-12-21 | Teijin Ltd | 1alpha-hydroxy-24-dehydro-vitamin d3 and its preparation |
JPS5822479B2 (ja) * | 1977-09-07 | 1983-05-09 | 帝人株式会社 | 1α−ヒドロキシ−24−オキソ−ビタミンD↓3およびその製造法 |
US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
LU80545A1 (de) * | 1978-11-17 | 1980-06-05 | Hoffmann La Roche | Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden |
US4335120A (en) * | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
US4230701A (en) * | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
JPS55136229A (en) * | 1979-04-10 | 1980-10-23 | Teijin Ltd | Adjustment of bone metabolism in warm-blooded animal and drug for it |
JPS5626820A (en) * | 1979-08-10 | 1981-03-16 | Chugai Pharmaceut Co Ltd | Immunosuppressing agent |
US4338250A (en) * | 1981-04-27 | 1982-07-06 | Wisconsin Alumni Research Foundation | 1-Hydroxylation process |
CA1272953A (en) | 1984-10-08 | 1990-08-21 | Yuji Makino | Pharmaceutical composition for external use containing active-type vitamin d.sub.3 |
JPH0749435B2 (ja) * | 1988-07-04 | 1995-05-31 | 帝人株式会社 | 1α,3β,24−トリヒドロキシ−△▲上5▼−ステロイド類の製造方法 |
US5532228A (en) * | 1990-02-06 | 1996-07-02 | Schering Aktiengesellschaft | Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents |
US6251883B1 (en) | 1991-01-08 | 2001-06-26 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2 |
DE69233074T2 (de) | 1991-01-08 | 2004-03-18 | Bone Care International Inc., Madison | Verfahren zur Herstellung von 1-alpha-24-dihydroxy-Vitamin D2 |
US6166000A (en) * | 1991-01-08 | 2000-12-26 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-Dihydroxy vitamin . D.sub2 |
US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
US5789397A (en) * | 1991-01-08 | 1998-08-04 | Bone Care International, Inc. | Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2 |
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
DK0614456T3 (da) * | 1992-08-28 | 1999-12-06 | Bone Care Int Inc | 1alfa,24(S)-dihydroxy-vitamin D2, dets fremstilling og anvendelse |
IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
US5869472A (en) * | 1994-07-18 | 1999-02-09 | Bone Care International, Inc. | Synthesis of 1α-hydroxy vitamin D |
US6362350B1 (en) | 1999-07-01 | 2002-03-26 | Wisconsin Alumni Research Foundation | Crystalline 1α, 24(S)-dihydroxyvitamin D2 and method of purification thereof |
US7129230B2 (en) | 2001-03-12 | 2006-10-31 | Nestec S.A. | Method and product for treating cancer in pets |
US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
TW200714580A (en) * | 2005-10-14 | 2007-04-16 | Formosa Lab Inc | Process for preparing vitamin D analogs |
JP5492099B2 (ja) * | 2008-03-12 | 2014-05-14 | シトクロマ インコーポレイテッド | 安定化1,25−ジヒドロキシビタミンd2及びその製造方法 |
KR102300311B1 (ko) | 2017-04-18 | 2021-09-10 | 연성정밀화학(주) | 타칼시톨의 제조방법 및 그를 위한 중간체 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3901928A (en) * | 1973-01-10 | 1975-08-26 | Robert Henry Hesse | 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds |
US3928397A (en) * | 1973-03-02 | 1975-12-23 | Eisai Co Ltd | New 5-cholestene derivatives and preparation thereof |
-
1975
- 1975-06-02 US US05/583,115 patent/US4022891A/en not_active Expired - Lifetime
- 1975-06-04 GB GB24138/75A patent/GB1508042A/en not_active Expired
- 1975-06-04 GB GB44013/76A patent/GB1508043A/en not_active Expired
- 1975-06-09 SE SE7506560A patent/SE413096B/xx not_active IP Right Cessation
- 1975-06-17 NO NO752150A patent/NO145162C/no unknown
- 1975-06-17 CA CA229,466A patent/CA1051442A/en not_active Expired
- 1975-06-17 DK DK273375AA patent/DK142410B/da not_active IP Right Cessation
- 1975-06-18 DE DE752526981A patent/DE2526981C3/de not_active Expired
- 1975-06-18 NL NL7507268A patent/NL7507268A/xx unknown
- 1975-06-18 FR FR7519074A patent/FR2275196A1/fr active Granted
- 1975-06-18 CH CH793875A patent/CH618669A5/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK142410B (da) | 1980-10-27 |
NO752150L (en, 2012) | 1975-12-19 |
DE2526981A1 (de) | 1976-01-15 |
GB1508043A (en) | 1978-04-19 |
CA1051442A (en) | 1979-03-27 |
US4022891A (en) | 1977-05-10 |
NO145162C (no) | 1982-01-27 |
FR2275196A1 (fr) | 1976-01-16 |
DK142410C (en, 2012) | 1981-03-23 |
NL7507268A (nl) | 1975-12-22 |
DE2526981B2 (de) | 1978-06-29 |
DE2526981C3 (de) | 1979-03-01 |
SE413096B (sv) | 1980-04-14 |
CH618669A5 (en, 2012) | 1980-08-15 |
FR2275196B1 (en, 2012) | 1978-10-06 |
NO145162B (no) | 1981-10-19 |
SE7506560L (sv) | 1975-12-19 |
DK273375A (en, 2012) | 1975-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 19950603 |