ES8801660A1 - Un procedimiento para preparar derivados de penem - Google Patents
Un procedimiento para preparar derivados de penemInfo
- Publication number
- ES8801660A1 ES8801660A1 ES551562A ES551562A ES8801660A1 ES 8801660 A1 ES8801660 A1 ES 8801660A1 ES 551562 A ES551562 A ES 551562A ES 551562 A ES551562 A ES 551562A ES 8801660 A1 ES8801660 A1 ES 8801660A1
- Authority
- ES
- Spain
- Prior art keywords
- antibacterial
- thia
- azabicyclo
- hept
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- OTTZHAVKAVGASB-UHFFFAOYSA-N hept-2-ene Chemical class CCCCC=CC OTTZHAVKAVGASB-UHFFFAOYSA-N 0.000 title 1
- FJNCXZZQNBKEJT-UHFFFAOYSA-N 8beta-hydroxymarrubiin Natural products O1C(=O)C2(C)CCCC3(C)C2C1CC(C)(O)C3(O)CCC=1C=COC=1 FJNCXZZQNBKEJT-UHFFFAOYSA-N 0.000 abstract 1
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/90—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl and carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PENEM, DE FORMULA GENERAL (I), Y SUS SALES FISIOLOGICAMENTE TOLERABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ESTERIFICANTE QUE PUEDE CONVERTIRSE POR HIDROLISIS, FOTOLISIS, REDUCCION O POR LA ACCION DE ENZIMAS ESTERASAS, PARA DAR ACIDO LIBRE, CON UN AGENTE CAPAZ DE ACTIVAR EL GRUPO CARBOXI LIBRE DEL GRUPO FENOXI, PARA CONVERTIR DICHO GRUPO CARBOXI LIBRE EN UN ESTER ACTIVADO, LLEVANDOSE A EFECTO LA REACCION EN UN DISOLVENTE INERTE Y A UNA TEMPERATURA COMPRENDIDA ENTRE C40 Y 40 GRADOS. DE APLICACION COMO COMPUESTOS INTERMEDIOS PARA LA PREPARACION DE OTROS DERIVADOS DE PENEM
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848416565A GB8416565D0 (en) | 1984-06-29 | 1984-06-29 | Antibacterial derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES551562A0 ES551562A0 (es) | 1988-02-16 |
ES8801660A1 true ES8801660A1 (es) | 1988-02-16 |
Family
ID=10563160
Family Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544625A Expired ES8707963A1 (es) | 1984-06-29 | 1985-06-27 | Un procedimiento para preparar derivados de penem |
ES551562A Expired ES8801660A1 (es) | 1984-06-29 | 1986-02-01 | Un procedimiento para preparar derivados de penem |
ES551561A Expired ES9000004A1 (es) | 1984-06-29 | 1986-02-01 | Un procedimiento para preparar derivados de penem |
ES557090A Expired ES8707497A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557087A Expired ES8707495A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557091A Expired ES8707498A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557092A Expired ES8800898A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557089A Expired ES8707540A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de penem |
ES557088A Expired ES8707496A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557086A Expired ES8707539A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de penem |
ES557535A Expired ES8801661A1 (es) | 1984-06-29 | 1987-05-13 | Un procedimiento para preparar derivados de penem |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544625A Expired ES8707963A1 (es) | 1984-06-29 | 1985-06-27 | Un procedimiento para preparar derivados de penem |
Family Applications After (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES551561A Expired ES9000004A1 (es) | 1984-06-29 | 1986-02-01 | Un procedimiento para preparar derivados de penem |
ES557090A Expired ES8707497A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557087A Expired ES8707495A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557091A Expired ES8707498A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557092A Expired ES8800898A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557089A Expired ES8707540A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de penem |
ES557088A Expired ES8707496A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
ES557086A Expired ES8707539A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de penem |
ES557535A Expired ES8801661A1 (es) | 1984-06-29 | 1987-05-13 | Un procedimiento para preparar derivados de penem |
Country Status (17)
Country | Link |
---|---|
US (1) | US4795748A (es) |
EP (1) | EP0170028A1 (es) |
JP (1) | JPS6118760A (es) |
KR (1) | KR860000300A (es) |
AU (1) | AU583521B2 (es) |
DK (1) | DK296085A (es) |
ES (11) | ES8707963A1 (es) |
FI (1) | FI852554L (es) |
GB (2) | GB8416565D0 (es) |
GR (1) | GR851584B (es) |
HU (3) | HU196748B (es) |
IL (1) | IL75675A0 (es) |
NO (3) | NO852356L (es) |
NZ (1) | NZ212572A (es) |
PH (1) | PH22117A (es) |
PT (1) | PT80736B (es) |
ZA (1) | ZA854901B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2195627A (en) * | 1986-08-12 | 1988-04-13 | Hoechst Uk Ltd | Penem derivatives |
ES2058328T3 (es) * | 1987-02-11 | 1994-11-01 | Ciba Geigy Ag | Acidos beta-lactama carboxilicos biciclicos. |
AT392903B (de) * | 1987-10-08 | 1991-07-10 | Hoechst Ag | Pharmazeutische zubereitung enthaltend ein cephalosporin und ein penemantibiotikum |
SE535691C2 (sv) | 2011-03-08 | 2012-11-13 | Kat2Biz Ab | Reduktion av C-O-bindningar via katalytisk transfer hydrogenolys |
CA2887296C (en) * | 2012-10-12 | 2018-12-04 | Eli Lilly And Company | Chemical engines and methods for their use, especially in the injection of highly viscous fluids |
WO2018152018A1 (en) | 2017-02-17 | 2018-08-23 | Eli Lilly And Company | Processes and devices for delivery of fluid by chemical reaction |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
JPS5625110A (en) * | 1978-12-18 | 1981-03-10 | Bristol Myers Co | Antibacterial |
ES8305366A1 (es) * | 1981-07-08 | 1983-04-01 | Hoechst Uk Ltd | "procedimiento para la preparacion de derivados de penem". |
DE3274982D1 (en) * | 1981-07-08 | 1987-02-12 | Hoechst Uk Ltd | Antibacterial penem derivatives |
GR78890B (es) * | 1982-07-08 | 1984-10-02 | Hoechst Uk Ltd | |
GB2164334B (en) * | 1984-09-10 | 1988-08-03 | Hoechst Uk Ltd | Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess |
-
1984
- 1984-06-29 GB GB848416565A patent/GB8416565D0/en active Pending
-
1985
- 1985-06-11 NO NO852356A patent/NO852356L/no unknown
- 1985-06-19 EP EP85107547A patent/EP0170028A1/en not_active Withdrawn
- 1985-06-24 HU HU855309A patent/HU196748B/hu unknown
- 1985-06-24 HU HU855310A patent/HU196809B/hu unknown
- 1985-06-24 HU HU852470A patent/HU194890B/hu not_active IP Right Cessation
- 1985-06-27 NZ NZ212572A patent/NZ212572A/xx unknown
- 1985-06-27 GR GR851584A patent/GR851584B/el unknown
- 1985-06-27 FI FI852554A patent/FI852554L/fi not_active Application Discontinuation
- 1985-06-27 US US06/749,384 patent/US4795748A/en not_active Expired - Fee Related
- 1985-06-27 ES ES544625A patent/ES8707963A1/es not_active Expired
- 1985-06-27 PH PH32465A patent/PH22117A/en unknown
- 1985-06-28 JP JP60140707A patent/JPS6118760A/ja active Pending
- 1985-06-28 IL IL75675A patent/IL75675A0/xx unknown
- 1985-06-28 ZA ZA854901A patent/ZA854901B/xx unknown
- 1985-06-28 PT PT80736A patent/PT80736B/pt unknown
- 1985-06-28 KR KR1019850004633A patent/KR860000300A/ko not_active Application Discontinuation
- 1985-06-28 AU AU44408/85A patent/AU583521B2/en not_active Expired - Fee Related
- 1985-06-28 GB GB8516493A patent/GB2161161B/en not_active Expired
- 1985-06-28 DK DK296085A patent/DK296085A/da not_active Application Discontinuation
-
1986
- 1986-02-01 ES ES551562A patent/ES8801660A1/es not_active Expired
- 1986-02-01 ES ES551561A patent/ES9000004A1/es not_active Expired
- 1986-03-14 NO NO860975A patent/NO860975L/no unknown
- 1986-03-14 NO NO860974A patent/NO860974L/no unknown
- 1986-09-29 ES ES557090A patent/ES8707497A1/es not_active Expired
- 1986-09-29 ES ES557087A patent/ES8707495A1/es not_active Expired
- 1986-09-29 ES ES557091A patent/ES8707498A1/es not_active Expired
- 1986-09-29 ES ES557092A patent/ES8800898A1/es not_active Expired
- 1986-09-29 ES ES557089A patent/ES8707540A1/es not_active Expired
- 1986-09-29 ES ES557088A patent/ES8707496A1/es not_active Expired
- 1986-09-29 ES ES557086A patent/ES8707539A1/es not_active Expired
-
1987
- 1987-05-13 ES ES557535A patent/ES8801661A1/es not_active Expired
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU565898B2 (en) | 1,8-naphthyridine derivatives | |
ES8401468A1 (es) | Un procedimiento para preparar derivados de nicotinamida. | |
ES8305356A1 (es) | Un procedimiento para la produccion de un derivado de carbostirilo | |
ES8303411A1 (es) | Un procedimiento para la preparacion de derivados de tiofilina o teobromina. | |
ES8308556A1 (es) | Un procedimiento para la preparacion de nuevos derivados de octahidronaftaleno. | |
ES8801289A1 (es) | Un metodo para preparar derivados de cefem | |
MY102433A (en) | Heterocyclic compounds | |
EP0228845A3 (en) | N-containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same | |
ES8707525A1 (es) | Un procedimiento para la preparacion de nuevas isoindolinil-alquilpiperazinas | |
ES8801660A1 (es) | Un procedimiento para preparar derivados de penem | |
ES8800122A1 (es) | Un procedimiento para la preparacion de derivados de indeno y naftaleno. | |
ES8702433A1 (es) | Un procedimiento para la preparacion de un compuesto heterociclico sustituido con peptidos. | |
ES2000907A6 (es) | Procedimiento de preparar compuestos 2-oxaisocefen microbiologicamente activos | |
DE3377277D1 (en) | Fungicidally active compounds | |
GB9220876D0 (en) | Compounds useful in oleaginous compositions | |
TW282470B (es) | ||
ES475588A1 (es) | Procedimiento para la obtencion de derivados del acido inde-no -2,1-b- tiofen-2-oxamico | |
ES8707726A1 (es) | Un procedimiento para la obtencion de compuestos de 1-oxa-1-destia-cefalos-porina | |
ES8400084A1 (es) | Procedimiento para preparar n-alcoxisulfenicarbamatos. | |
AU557979B2 (en) | Thiazolidin-and hydrothiazin-derivatives | |
ES8705426A1 (es) | Un procedimiento para la preparacion de un derivado de piperazina. | |
ES459705A1 (es) | Procedimiento para la preparacion de derivados de hidracina-piridacina. | |
ES8504772A1 (es) | Un procedimiento para preparar un compuesto de 7-(4-piridil)-1,8-naftiridina. | |
ES8304990A1 (es) | Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos. | |
ES8702877A1 (es) | Un metodo para producir un derivado de acido benzoico. |