GB1497266A - Aryloxy-and arylthio-alkanoates having cholesterol-reducing properties - Google Patents
Aryloxy-and arylthio-alkanoates having cholesterol-reducing propertiesInfo
- Publication number
- GB1497266A GB1497266A GB55755/74A GB5575574A GB1497266A GB 1497266 A GB1497266 A GB 1497266A GB 55755/74 A GB55755/74 A GB 55755/74A GB 5575574 A GB5575574 A GB 5575574A GB 1497266 A GB1497266 A GB 1497266A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- hydrogen
- carbon atoms
- alkoxycarbonyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 benzylthio group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 abstract 1
- 101100188552 Arabidopsis thaliana OCT3 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003312 cholesterol blood level Effects 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Testing Resistance To Weather, Investigating Materials By Mechanical Methods (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1814473A CH605557A5 (en) | 1973-12-27 | 1973-12-27 | Phenoxy- and phenylthio-alkanes |
| CH1814573A CH601169A5 (en) | 1973-12-27 | 1973-12-27 | Phenoxy- and phenylthio-alkanes |
| CH435574A CH605642A5 (en) | 1974-03-28 | 1974-03-28 | Phenoxy- and phenylthio-alkanes |
| CH1330274A CH616909A5 (en) | 1974-10-03 | 1974-10-03 | Process for the preparation of aromatically substituted olefins |
| CH1532974A CH617417A5 (enrdf_load_stackoverflow) | 1973-12-27 | 1974-11-18 | |
| CH1533074A CH617420A5 (en) | 1974-11-18 | 1974-11-18 | Process for the preparation of novel pivaloyloxymethyl esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1497266A true GB1497266A (en) | 1978-01-05 |
Family
ID=27543738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55755/74A Expired GB1497266A (en) | 1973-12-27 | 1974-12-24 | Aryloxy-and arylthio-alkanoates having cholesterol-reducing properties |
Country Status (11)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211551A (en) * | 1976-11-15 | 1980-07-08 | Siegfried Ag | Herbicide |
| US4214095A (en) * | 1979-01-25 | 1980-07-22 | Siegfried Aktiengesellschaft | Chlorobenzyl phenoxy alkoxylates |
| FR2481702A1 (fr) * | 1980-04-30 | 1981-11-06 | Anvar | Phenoxyacetates substitues d'amines cycliques, procede d'obtention, applications a titre de medicaments et compositions pharmaceutiques les contenant |
| DE3037391A1 (de) * | 1980-10-03 | 1982-05-19 | King Consult GmbH, 5000 Köln | Ester von 7-hydroxyalkyl-1,3-dimethylxanthinen, verfahren zu ihrer herstellung und ihre verwendung als lipidsenkende mittel |
| DE3264994D1 (en) * | 1981-03-11 | 1985-09-05 | Merckle Kg Chem Pharm L | Process for the preparation of phenoxyalcanecarbonic-acid esters of hydroxyethyl theophyline |
| JPS59172440A (ja) * | 1983-03-23 | 1984-09-29 | Nippon Tokushu Noyaku Seizo Kk | 置換フエノキシプロピオン酸エステル及びその中間体、それらの製法並びに除草剤 |
| DE3891219T1 (de) * | 1988-01-22 | 1990-02-01 | Kh Nii Endokrinologii I Chimii | P-chlorphenoxysobuttersaeureundezylester und arzneimittel auf dessen grundlage zur behandlung der hyperlipidaemie |
| DE102011006425A1 (de) | 2010-03-31 | 2011-10-06 | Awd.Pharma Gmbh & Co. Kg | Pharmazeutische Zubereitung und deren Verwendung |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB860303A (en) * | 1958-06-20 | 1961-02-01 | Ici Ltd | Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª |
| GB1064252A (en) * | 1963-09-19 | 1967-04-05 | Ici Ltd | Amides and pharmaceutical compositions containing them |
| FR1498459A (enrdf_load_stackoverflow) | 1965-07-30 | 1968-01-08 | ||
| GB1121722A (en) * | 1966-03-31 | 1968-07-31 | Ici Ltd | New carboxylic acid derivatives |
| GB1140748A (en) * | 1966-06-23 | 1969-01-22 | Ici Ltd | New carboxylic acid derivatives |
| DE2149070C3 (de) * | 1971-10-01 | 1978-03-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Phenoxyalkylcarbonsäurederivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel |
| GB1422679A (en) * | 1972-11-16 | 1976-01-28 | Funai Pharmaceutical Ind Ltd | Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same |
| DE2308826C3 (de) * | 1973-02-22 | 1980-03-27 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | Phenoxyalkancarbonsäureester von Oxyalkyltheophyllinen, Verfahren zu ihrer Herstellung und Arzneimittel |
-
1974
- 1974-12-17 NL NL7416412A patent/NL7416412A/xx not_active Application Discontinuation
- 1974-12-20 DK DK670274A patent/DK157005C/da not_active IP Right Cessation
- 1974-12-20 SE SE7416163A patent/SE426582B/xx not_active IP Right Cessation
- 1974-12-23 DE DE2463001A patent/DE2463001C2/de not_active Expired
- 1974-12-23 DE DE2461069A patent/DE2461069C3/de not_active Expired
- 1974-12-23 IE IE2658/74A patent/IE42425B1/en unknown
- 1974-12-24 LU LU71561A patent/LU71561A1/xx unknown
- 1974-12-24 GB GB55755/74A patent/GB1497266A/en not_active Expired
- 1974-12-25 SU SU742090104A patent/SU612619A3/ru active
- 1974-12-27 JP JP49149036A patent/JPS5934695B2/ja not_active Expired
- 1974-12-27 BE BE151969A patent/BE823904A/xx not_active IP Right Cessation
- 1974-12-27 FR FR7443033A patent/FR2255891B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5934695B2 (ja) | 1984-08-24 |
| BE823904A (fr) | 1975-06-27 |
| SE7416163L (enrdf_load_stackoverflow) | 1975-06-30 |
| JPS50105621A (enrdf_load_stackoverflow) | 1975-08-20 |
| AU7690274A (en) | 1976-07-01 |
| SU612619A3 (ru) | 1978-06-25 |
| DE2461069C3 (de) | 1981-07-23 |
| LU71561A1 (enrdf_load_stackoverflow) | 1975-08-20 |
| DE2463001C2 (enrdf_load_stackoverflow) | 1988-11-24 |
| DE2461069B2 (de) | 1980-10-02 |
| FR2255891B1 (enrdf_load_stackoverflow) | 1978-11-10 |
| DE2461069A1 (de) | 1975-07-17 |
| DK157005B (da) | 1989-10-30 |
| SE426582B (sv) | 1983-01-31 |
| FR2255891A1 (enrdf_load_stackoverflow) | 1975-07-25 |
| DK157005C (da) | 1990-03-26 |
| IE42425B1 (en) | 1980-08-13 |
| IE42425L (en) | 1975-06-27 |
| NL7416412A (nl) | 1975-07-01 |
| DK670274A (enrdf_load_stackoverflow) | 1975-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |