GB1493960A - Process for the isolation of a polyvalent proteinase inhibitor - Google Patents
Process for the isolation of a polyvalent proteinase inhibitorInfo
- Publication number
- GB1493960A GB1493960A GB6296/75A GB629675A GB1493960A GB 1493960 A GB1493960 A GB 1493960A GB 6296/75 A GB6296/75 A GB 6296/75A GB 629675 A GB629675 A GB 629675A GB 1493960 A GB1493960 A GB 1493960A
- Authority
- GB
- United Kingdom
- Prior art keywords
- inhibitor
- acid resins
- proteinase inhibitor
- isolation
- acrylamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- 239000011347 resin Substances 0.000 abstract 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000003463 adsorbent Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 229920006322 acrylamide copolymer Polymers 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 210000001557 animal structure Anatomy 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2406971A DE2406971B2 (de) | 1974-02-14 | 1974-02-14 | Verfahren zur Gewinnung eines polyvalenten Proteinasen-Inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1493960A true GB1493960A (en) | 1977-12-07 |
Family
ID=5907334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6296/75A Expired GB1493960A (en) | 1974-02-14 | 1975-02-14 | Process for the isolation of a polyvalent proteinase inhibitor |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS50111211A (it) |
| AT (1) | AT338414B (it) |
| BE (1) | BE825570A (it) |
| CH (1) | CH610909A5 (it) |
| DE (1) | DE2406971B2 (it) |
| DK (1) | DK145468B (it) |
| FR (1) | FR2261286B1 (it) |
| GB (1) | GB1493960A (it) |
| IE (1) | IE40600B1 (it) |
| IL (1) | IL46587A (it) |
| IT (1) | IT1043948B (it) |
| LU (1) | LU71826A1 (it) |
| NL (1) | NL7501488A (it) |
| SE (1) | SE7501654L (it) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2527222A1 (fr) * | 1982-05-19 | 1983-11-25 | Christine Fougnot | Procede de separation et de purification des proteases et des antiproteases de la coagulation sanguine, ainsi que du complexe protease/antiprotease |
-
1974
- 1974-02-14 DE DE2406971A patent/DE2406971B2/de not_active Ceased
-
1975
- 1975-02-07 NL NL7501488A patent/NL7501488A/xx not_active Application Discontinuation
- 1975-02-07 IL IL46587A patent/IL46587A/en unknown
- 1975-02-12 LU LU71826A patent/LU71826A1/xx unknown
- 1975-02-12 IT IT20216/75A patent/IT1043948B/it active
- 1975-02-13 CH CH174675A patent/CH610909A5/xx not_active IP Right Cessation
- 1975-02-13 AT AT107175A patent/AT338414B/de not_active IP Right Cessation
- 1975-02-13 DK DK52175AA patent/DK145468B/da not_active Application Discontinuation
- 1975-02-13 IE IE280/75A patent/IE40600B1/xx unknown
- 1975-02-13 JP JP50017517A patent/JPS50111211A/ja active Pending
- 1975-02-14 GB GB6296/75A patent/GB1493960A/en not_active Expired
- 1975-02-14 FR FR7504757A patent/FR2261286B1/fr not_active Expired
- 1975-02-14 SE SE7501654A patent/SE7501654L/ not_active Application Discontinuation
- 1975-02-14 BE BE153395A patent/BE825570A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7501488A (nl) | 1975-08-18 |
| JPS50111211A (it) | 1975-09-01 |
| CH610909A5 (en) | 1979-05-15 |
| ATA107175A (de) | 1976-12-15 |
| LU71826A1 (it) | 1976-12-31 |
| FR2261286A1 (it) | 1975-09-12 |
| IL46587A (en) | 1977-06-30 |
| BE825570A (fr) | 1975-08-14 |
| DE2406971B2 (de) | 1979-08-09 |
| IE40600B1 (en) | 1979-07-04 |
| IE40600L (en) | 1975-08-14 |
| DK52175A (it) | 1975-10-06 |
| AT338414B (de) | 1977-08-25 |
| IT1043948B (it) | 1980-02-29 |
| IL46587A0 (en) | 1975-04-25 |
| FR2261286B1 (it) | 1979-04-06 |
| DE2406971A1 (de) | 1975-08-21 |
| DK145468B (da) | 1982-11-22 |
| SE7501654L (it) | 1975-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |