IE40600L - Isolation of a polyvalent proteinase inhibitor from animal¹organs by means of ion exchange - Google Patents
Isolation of a polyvalent proteinase inhibitor from animal¹organs by means of ion exchangeInfo
- Publication number
- IE40600L IE40600L IE750280A IE28075A IE40600L IE 40600 L IE40600 L IE 40600L IE 750280 A IE750280 A IE 750280A IE 28075 A IE28075 A IE 28075A IE 40600 L IE40600 L IE 40600L
- Authority
- IE
- Ireland
- Prior art keywords
- inhibitor
- acid resins
- proteinase inhibitor
- isolation
- ion exchange
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The production of a polyvalent proteinase inhibitor from animal organs, in particular from lung, is carried out by adsorbing the inhibitor from its aqueous solutions by adsorption on an ion exchanger having functional sulphonate or phosphonate groups at pH 0.5 to 10.5 and eluting it with water or a salt solution at pH 1 to 13. A suitable adsorbent, in particular, is an ethenesulphonate/ acrylamide copolymer gel, as is obtained by copolymerisation of ethenesulphonic acid and acrylamide in the weight ratio 20:1 to 2:1 and subsequent crosslinking with 1 to 15 % formaldehyde. Further suitable adsorbents are polyphenolomega -sulphonic acid resins and also polystyrenesulphonic acid resins and polystyrene phosphonic acid resins. The inhibitor obtained by this process is suitable for therapeutic use on account of its high degree of purity. It can additionally be employed, for example, as a stabiliser for standardised protein preparations.
[GB1493960A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2406971A DE2406971B2 (en) | 1974-02-14 | 1974-02-14 | Process for obtaining a polyvalent proteinase inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40600L true IE40600L (en) | 1975-08-14 |
| IE40600B1 IE40600B1 (en) | 1979-07-04 |
Family
ID=5907334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE280/75A IE40600B1 (en) | 1974-02-14 | 1975-02-13 | Process for the isolation of apolyvalent proteinase inhibitor |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS50111211A (en) |
| AT (1) | AT338414B (en) |
| BE (1) | BE825570A (en) |
| CH (1) | CH610909A5 (en) |
| DE (1) | DE2406971B2 (en) |
| DK (1) | DK145468B (en) |
| FR (1) | FR2261286B1 (en) |
| GB (1) | GB1493960A (en) |
| IE (1) | IE40600B1 (en) |
| IL (1) | IL46587A (en) |
| IT (1) | IT1043948B (en) |
| LU (1) | LU71826A1 (en) |
| NL (1) | NL7501488A (en) |
| SE (1) | SE7501654L (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2527222A1 (en) * | 1982-05-19 | 1983-11-25 | Christine Fougnot | METHOD FOR SEPARATING AND PURIFYING PROTEASES AND ANTIPROTEASES OF BLOOD COAGULATION, AS WELL AS PROTEASE / ANTIPROTEASE COMPLEX |
-
1974
- 1974-02-14 DE DE2406971A patent/DE2406971B2/en not_active Ceased
-
1975
- 1975-02-07 NL NL7501488A patent/NL7501488A/en not_active Application Discontinuation
- 1975-02-07 IL IL46587A patent/IL46587A/en unknown
- 1975-02-12 IT IT20216/75A patent/IT1043948B/en active
- 1975-02-12 LU LU71826A patent/LU71826A1/xx unknown
- 1975-02-13 DK DK52175AA patent/DK145468B/en not_active Application Discontinuation
- 1975-02-13 CH CH174675A patent/CH610909A5/en not_active IP Right Cessation
- 1975-02-13 JP JP50017517A patent/JPS50111211A/ja active Pending
- 1975-02-13 IE IE280/75A patent/IE40600B1/en unknown
- 1975-02-13 AT AT107175A patent/AT338414B/en not_active IP Right Cessation
- 1975-02-14 FR FR7504757A patent/FR2261286B1/fr not_active Expired
- 1975-02-14 GB GB6296/75A patent/GB1493960A/en not_active Expired
- 1975-02-14 SE SE7501654A patent/SE7501654L/ not_active Application Discontinuation
- 1975-02-14 BE BE153395A patent/BE825570A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1493960A (en) | 1977-12-07 |
| DK145468B (en) | 1982-11-22 |
| SE7501654L (en) | 1975-08-15 |
| IL46587A (en) | 1977-06-30 |
| JPS50111211A (en) | 1975-09-01 |
| IT1043948B (en) | 1980-02-29 |
| DE2406971B2 (en) | 1979-08-09 |
| LU71826A1 (en) | 1976-12-31 |
| FR2261286B1 (en) | 1979-04-06 |
| CH610909A5 (en) | 1979-05-15 |
| NL7501488A (en) | 1975-08-18 |
| ATA107175A (en) | 1976-12-15 |
| BE825570A (en) | 1975-08-14 |
| DE2406971A1 (en) | 1975-08-21 |
| AT338414B (en) | 1977-08-25 |
| FR2261286A1 (en) | 1975-09-12 |
| IE40600B1 (en) | 1979-07-04 |
| IL46587A0 (en) | 1975-04-25 |
| DK52175A (en) | 1975-10-06 |
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