GB906860A - Improvements relating to blood coagulation test reagents - Google Patents

Improvements relating to blood coagulation test reagents

Info

Publication number
GB906860A
GB906860A GB1183761A GB1183761A GB906860A GB 906860 A GB906860 A GB 906860A GB 1183761 A GB1183761 A GB 1183761A GB 1183761 A GB1183761 A GB 1183761A GB 906860 A GB906860 A GB 906860A
Authority
GB
United Kingdom
Prior art keywords
plasma
serum
species
blood
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1183761A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KENNETH WILLIAM ERNEST DENSON
Original Assignee
KENNETH WILLIAM ERNEST DENSON
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KENNETH WILLIAM ERNEST DENSON filed Critical KENNETH WILLIAM ERNEST DENSON
Priority to GB1183761A priority Critical patent/GB906860A/en
Publication of GB906860A publication Critical patent/GB906860A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Abstract

A substrate plasma, useful in the assay of blood coagulation factors in human beings and other species, is prepared by treating blood plasma from a first species of animal with an adsorbent (as hereinafter disclosed) to remove therefrom all but a small residual amount of one or more blood coagulation factors and adding to the treated plasma a small proportion of a serum from a second species of animal containing antiobodies immunologically specific for the said coagulation factors to remove the small residual amount of the said factor or factors from the plasma. The serum is obtained by injecting an animal of the second species with a concentrate containing the said one or more coagulation factors which has been prepared from the blood plasma or serum of an animal of the first species, drawing blood from the animal after an interval of time in which the antibodies have developed and separating the serum from the blood so obtained. The concentrate is prepared by treating plasma or serum from the first species with an adsorbent to adsorb one or more coagulation factors therefrom, separating the adsorbent from the plasma or serum, eluting the adsorbed factors and concentrating the eluate to obtain a concentrate of said coagulation factors. Specified adsorbents are calcium phosphate, barium sulphate, asbestos and an ion exchange cellulose derivative. Aqueous solution of sodium citrate may be used for elution. The substrate plasma mixed with thromboplastin, calcium chloride and a barbitone buffer is lyophilised for storage and is reconstituted with distilled water for use.
GB1183761A 1961-03-30 1961-03-30 Improvements relating to blood coagulation test reagents Expired GB906860A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1183761A GB906860A (en) 1961-03-30 1961-03-30 Improvements relating to blood coagulation test reagents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1183761A GB906860A (en) 1961-03-30 1961-03-30 Improvements relating to blood coagulation test reagents

Publications (1)

Publication Number Publication Date
GB906860A true GB906860A (en) 1962-09-26

Family

ID=9993621

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1183761A Expired GB906860A (en) 1961-03-30 1961-03-30 Improvements relating to blood coagulation test reagents

Country Status (1)

Country Link
GB (1) GB906860A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005243A2 (en) * 1978-04-27 1979-11-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Control plasma, its preparation, its use in oral anticoagulant therapy control and testkit containing this control plasma
WO2012104418A3 (en) * 2011-02-04 2012-10-04 Octapharma Ag Method for inactivation/removal of coagulation factors by precipitation
US11604026B2 (en) 2019-03-14 2023-03-14 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11634257B2 (en) 2017-10-09 2023-04-25 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005243A2 (en) * 1978-04-27 1979-11-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Control plasma, its preparation, its use in oral anticoagulant therapy control and testkit containing this control plasma
EP0005243A3 (en) * 1978-04-27 1980-03-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Control plasma, its preparation, its use in oral anticoagulant therapy control and testkit containing this control plasma
US4271122A (en) * 1978-04-27 1981-06-02 Hoffmann-La Roche Inc. Control plasma
US10640548B2 (en) 2011-02-04 2020-05-05 Octapharma Ag Method for inactivation/removal of coagulation factors by precipitation
US9901597B2 (en) 2011-02-04 2018-02-27 Octapharma Ag Method for inactivation/removal of coagulation factors by precipitation
EP2670429B1 (en) 2011-02-04 2018-04-04 Octapharma AG Method for inactivation/removal of coagulation factors by precipitation
WO2012104418A3 (en) * 2011-02-04 2012-10-04 Octapharma Ag Method for inactivation/removal of coagulation factors by precipitation
US11634257B2 (en) 2017-10-09 2023-04-25 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
US11604026B2 (en) 2019-03-14 2023-03-14 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11609043B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Lyophilization container fill fixture, system and method of use
US11609042B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
US11740019B2 (en) 2019-03-14 2023-08-29 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11747082B2 (en) 2019-03-14 2023-09-05 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
US11815311B2 (en) 2019-03-14 2023-11-14 Terumo Bct Biotechnologies, Llc Lyophilization container fill fixture, system and method of use

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