GB1478774A - Polycyclic antidepressants - Google Patents
Polycyclic antidepressantsInfo
- Publication number
- GB1478774A GB1478774A GB45404/75A GB4540475A GB1478774A GB 1478774 A GB1478774 A GB 1478774A GB 45404/75 A GB45404/75 A GB 45404/75A GB 4540475 A GB4540475 A GB 4540475A GB 1478774 A GB1478774 A GB 1478774A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- reacting
- compounds
- pyridine
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000935 antidepressant agent Substances 0.000 title abstract 2
- 229940005513 antidepressants Drugs 0.000 title abstract 2
- 125000003367 polycyclic group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 9
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- -1 p - toluenesulphonyl Chemical group 0.000 abstract 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 229910000102 alkali metal hydride Inorganic materials 0.000 abstract 1
- 150000008046 alkali metal hydrides Chemical class 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- SNVTZAIYUGUKNI-UHFFFAOYSA-N dibenzo[1,2-a:1',2'-e][7]annulen-11-one Chemical class C1=CC2=CC=CC=C2C(=O)C2=CC=CC=C21 SNVTZAIYUGUKNI-UHFFFAOYSA-N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52587774A | 1974-11-21 | 1974-11-21 | |
| US05/616,483 US3960956A (en) | 1974-11-21 | 1975-09-26 | Antidepressant 1,1a,6,10b-tetrahydrodibenzo(a,e)-cyclo-propa(c) cyclohepten-6-substituted oximes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1478774A true GB1478774A (en) | 1977-07-06 |
Family
ID=27061932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB45404/75A Expired GB1478774A (en) | 1974-11-21 | 1975-10-31 | Polycyclic antidepressants |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US3960956A (enExample) |
| JP (1) | JPS5848547B2 (enExample) |
| AR (1) | AR208572A1 (enExample) |
| AU (1) | AU503261B2 (enExample) |
| CA (1) | CA1074788A (enExample) |
| CH (1) | CH622775A5 (enExample) |
| DD (1) | DD122084A5 (enExample) |
| DE (1) | DE2551105A1 (enExample) |
| DK (1) | DK147281C (enExample) |
| ES (1) | ES442850A1 (enExample) |
| FI (1) | FI61876C (enExample) |
| FR (1) | FR2291744A1 (enExample) |
| GB (1) | GB1478774A (enExample) |
| HU (1) | HU173442B (enExample) |
| IL (1) | IL48501A (enExample) |
| LU (1) | LU73839A1 (enExample) |
| NL (1) | NL7513508A (enExample) |
| NO (1) | NO141440C (enExample) |
| PH (1) | PH12278A (enExample) |
| SE (1) | SE424318B (enExample) |
| YU (1) | YU36920B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2658938A1 (de) * | 1976-12-24 | 1978-07-06 | Hoechst Ag | Neue basisch substituierte 0-propyloxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3349128A (en) * | 1965-06-28 | 1967-10-24 | Colgate Palmolive Co | Production of omicron-(monoalkyl aminoalkyl) oximes of dibenzo-[a, d] cyclohepten-5-ones |
| US3574199A (en) * | 1968-06-28 | 1971-04-06 | Searle & Co | 6-(aminoalkyl- and aminoalkylidene)-1,1a,6,10b -tetrahydro-dibenzo(a,e)cyclopropa(c)cycloheptenes |
| US3901945A (en) * | 1972-09-28 | 1975-08-26 | Du Pont | 1,1a,6,10b-tetrahydrodibenzo (a,e) cyclopropa (c) cyclohepten-6-imines |
-
1975
- 1975-09-26 US US05/616,483 patent/US3960956A/en not_active Expired - Lifetime
- 1975-10-15 SE SE7511557A patent/SE424318B/xx not_active IP Right Cessation
- 1975-10-31 GB GB45404/75A patent/GB1478774A/en not_active Expired
- 1975-11-14 DE DE19752551105 patent/DE2551105A1/de not_active Withdrawn
- 1975-11-19 CA CA240,001A patent/CA1074788A/en not_active Expired
- 1975-11-19 NL NL7513508A patent/NL7513508A/xx not_active Application Discontinuation
- 1975-11-19 YU YU2933/75A patent/YU36920B/xx unknown
- 1975-11-19 FR FR7535306A patent/FR2291744A1/fr active Granted
- 1975-11-20 IL IL48501A patent/IL48501A/xx unknown
- 1975-11-20 ES ES442850A patent/ES442850A1/es not_active Expired
- 1975-11-20 AU AU86770/75A patent/AU503261B2/en not_active Expired
- 1975-11-20 AR AR261300A patent/AR208572A1/es active
- 1975-11-20 NO NO753902A patent/NO141440C/no unknown
- 1975-11-20 DD DD189589A patent/DD122084A5/xx unknown
- 1975-11-20 LU LU73839A patent/LU73839A1/xx unknown
- 1975-11-20 PH PH17781A patent/PH12278A/en unknown
- 1975-11-20 DK DK523775A patent/DK147281C/da active
- 1975-11-20 FI FI753273A patent/FI61876C/fi not_active IP Right Cessation
- 1975-11-21 JP JP50140103A patent/JPS5848547B2/ja not_active Expired
- 1975-11-21 CH CH1513075A patent/CH622775A5/de not_active IP Right Cessation
- 1975-11-21 HU HU75DU243A patent/HU173442B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5848547B2 (ja) | 1983-10-28 |
| DK147281C (da) | 1984-12-03 |
| NO141440B (no) | 1979-12-03 |
| FI61876C (fi) | 1982-10-11 |
| NO753902L (enExample) | 1976-05-24 |
| US3960956A (en) | 1976-06-01 |
| IL48501A (en) | 1978-08-31 |
| DD122084A5 (enExample) | 1976-09-12 |
| ES442850A1 (es) | 1977-08-16 |
| SE7511557L (sv) | 1976-05-24 |
| AR208572A1 (es) | 1977-02-15 |
| YU293375A (en) | 1982-02-25 |
| IL48501A0 (en) | 1976-01-30 |
| DK523775A (da) | 1976-05-22 |
| AU503261B2 (en) | 1979-08-30 |
| FR2291744A1 (fr) | 1976-06-18 |
| CA1074788A (en) | 1980-04-01 |
| FR2291744B1 (enExample) | 1979-06-15 |
| YU36920B (en) | 1984-08-31 |
| HU173442B (hu) | 1979-05-28 |
| LU73839A1 (enExample) | 1976-06-11 |
| FI61876B (fi) | 1982-06-30 |
| JPS51125270A (en) | 1976-11-01 |
| DE2551105A1 (de) | 1976-05-26 |
| AU8677075A (en) | 1977-05-26 |
| FI753273A7 (enExample) | 1976-05-22 |
| CH622775A5 (enExample) | 1981-04-30 |
| DK147281B (da) | 1984-06-04 |
| SE424318B (sv) | 1982-07-12 |
| NL7513508A (nl) | 1976-05-25 |
| PH12278A (en) | 1978-12-12 |
| NO141440C (no) | 1980-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |