GB1469879A - Layered tablets comprising microcapsules and a method of making them - Google Patents
Layered tablets comprising microcapsules and a method of making themInfo
- Publication number
- GB1469879A GB1469879A GB2922674A GB2922674A GB1469879A GB 1469879 A GB1469879 A GB 1469879A GB 2922674 A GB2922674 A GB 2922674A GB 2922674 A GB2922674 A GB 2922674A GB 1469879 A GB1469879 A GB 1469879A
- Authority
- GB
- United Kingdom
- Prior art keywords
- microcapsules
- layer
- external
- contain
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003094 microcapsule Substances 0.000 title abstract 7
- 239000007942 layered tablet Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 3
- UOTMYNBWXDUBNX-UHFFFAOYSA-N 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinolin-2-ium;chloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 UOTMYNBWXDUBNX-UHFFFAOYSA-N 0.000 abstract 2
- 229920002261 Corn starch Polymers 0.000 abstract 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 229960003207 papaverine hydrochloride Drugs 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- XNLFHCPVTULKIV-VAWYXSNFSA-N (e)-3-(4-methylphenyl)-1-phenylprop-2-en-1-one Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)C1=CC=CC=C1 XNLFHCPVTULKIV-VAWYXSNFSA-N 0.000 abstract 1
- AGUNEISBPXQOPA-XMUHMHRVSA-N 4-Chloromethandienone Chemical compound C1CC2=C(Cl)C(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 AGUNEISBPXQOPA-XMUHMHRVSA-N 0.000 abstract 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 235000019759 Maize starch Nutrition 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 235000012730 carminic acid Nutrition 0.000 abstract 1
- 239000004106 carminic acid Substances 0.000 abstract 1
- 229940080423 cochineal Drugs 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000008120 corn starch Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- -1 polyoxyethylene Polymers 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7325531A FR2236483B1 (enrdf_load_stackoverflow) | 1973-07-12 | 1973-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1469879A true GB1469879A (en) | 1977-04-06 |
Family
ID=9122459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2922674A Expired GB1469879A (en) | 1973-07-12 | 1974-07-11 | Layered tablets comprising microcapsules and a method of making them |
Country Status (11)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139589A (en) * | 1975-02-26 | 1979-02-13 | Monique Beringer | Process for the manufacture of a multi-zone tablet and tablet manufactured by this process |
| US4316884A (en) * | 1979-01-25 | 1982-02-23 | Adria Laboratories, Inc. | Sustained release pharmaceutical formulation |
| US4637905A (en) * | 1982-03-04 | 1987-01-20 | Batelle Development Corporation | Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones |
| US4532123A (en) * | 1982-03-04 | 1985-07-30 | Battelle Development Corporation | Dual Microcapsules and process for their preparation |
| US4415547A (en) * | 1982-06-14 | 1983-11-15 | Sterling Drug Inc. | Sustained-release pharmaceutical tablet and process for preparation thereof |
| DE3228533A1 (de) * | 1982-07-30 | 1984-02-02 | Council of Scientific and Industrial Research, 110001 New Delhi | Verfahren zur herstellung von medizinischen pillen und so hergestellen pillen |
| HU187215B (en) * | 1983-01-26 | 1985-11-28 | Egyt Gyogyszervegyeszeti Gyar | Method for producing pharmaceutical product of high actor content and prolonged effect |
| JPS604120A (ja) * | 1983-06-22 | 1985-01-10 | Shionogi & Co Ltd | 作用持続型ピナシジル製剤 |
| JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| JPS61501197A (ja) * | 1984-03-29 | 1986-06-19 | レツペル−プラステイク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 印刷物の積み降ろし装置 |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| EP0190833B1 (en) * | 1985-02-07 | 1991-03-27 | Takeda Chemical Industries, Ltd. | Method for producing microcapsule |
| US4863741A (en) * | 1985-03-25 | 1989-09-05 | Abbott Laboratories | Tablet composition for drug combinations |
| US4874614A (en) * | 1985-03-25 | 1989-10-17 | Abbott Laboratories | Pharmaceutical tableting method |
| US5019302A (en) * | 1986-03-12 | 1991-05-28 | Washington University Technology Associates, Inc. | Method for granulation |
| US4710384A (en) * | 1986-07-28 | 1987-12-01 | Avner Rotman | Sustained release tablets made from microcapsules |
| FR2602423B1 (fr) * | 1986-08-08 | 1989-05-05 | Ethypharm Sa | Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede |
| US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
| JPH04230625A (ja) * | 1990-12-27 | 1992-08-19 | Standard Chem & Pharmaceut Corp Ltd | 噴霧乾燥したジクロフェナクナトリウムを含み腸溶性の被覆を有するマイクロカプセルからなる微分散した錠剤組成物の製造方法 |
| JPH0539288U (ja) * | 1991-10-31 | 1993-05-28 | 三栄源エフ・エフ・アイ株式会社 | 容器兼用食品 |
| CA2110313C (en) * | 1992-12-01 | 2004-10-26 | Edward John Roche | Pharmaceutical compositions containing a guanidinothiazole compound and antacids |
| TW333456B (en) * | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| US5593696A (en) * | 1994-11-21 | 1997-01-14 | Mcneil-Ppc, Inc. | Stabilized composition of famotidine and sucralfate for treatment of gastrointestinal disorders |
| US6663896B1 (en) | 2001-08-01 | 2003-12-16 | Alvin S. Blum | Delayed release aspirin for vascular obstruction prophylaxis |
| FR2831820B1 (fr) * | 2001-11-05 | 2004-08-20 | Ethypharm Sa | Comprime orodispersible presentant une grande homogeneite et son procede de preparation |
| DE10306468A1 (de) * | 2003-02-14 | 2004-09-02 | Henkel Kgaa | Aus Pulver und Mikrokapseln gepreßter Formkörper |
| KR101340946B1 (ko) * | 2004-08-04 | 2013-12-13 | 알자 코포레이션 | 오름차 0차 방출 패턴을 나타내는 약물의 서방성 조성물,상기 조성물을 제조하는 방법 |
| US20080286344A1 (en) * | 2007-05-16 | 2008-11-20 | Olivia Darmuzey | Solid form |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US462990A (en) * | 1891-11-10 | William oppenheimek | ||
| DE646035C (de) * | 1934-03-02 | 1937-06-07 | Fritz Weinmann Dr | Verfahren zur Herstellung von Arzneimitteltabletten aus mehreren Schichten |
| DE657259C (de) * | 1936-05-20 | 1938-03-01 | Ludwig Heumann & Co Chem Pharm | Pressling fuer pharmazeutische Zwecke |
| US3048526A (en) * | 1958-08-04 | 1962-08-07 | Wander Company | Medicinal tablet |
| US3096248A (en) * | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
| US3341416A (en) * | 1963-12-11 | 1967-09-12 | Ncr Co | Encapsulation of aspirin in ethylcellulose and its product |
| US3488418A (en) * | 1965-11-18 | 1970-01-06 | Sterling Drug Inc | Sustained relief analgesic composition |
| FR5788M (enrdf_load_stackoverflow) * | 1965-11-18 | 1968-03-18 |
-
1973
- 1973-07-12 FR FR7325531A patent/FR2236483B1/fr not_active Expired
-
1974
- 1974-07-09 NL NL7409295A patent/NL7409295A/xx not_active Application Discontinuation
- 1974-07-09 BE BE2053734A patent/BE817401A/xx not_active IP Right Cessation
- 1974-07-10 US US487042A patent/US3922338A/en not_active Expired - Lifetime
- 1974-07-11 GB GB2922674A patent/GB1469879A/en not_active Expired
- 1974-07-11 ES ES428171A patent/ES428171A1/es not_active Expired
- 1974-07-11 CA CA204,589A patent/CA1028622A/fr not_active Expired
- 1974-07-11 DE DE2433285A patent/DE2433285C2/de not_active Expired
- 1974-07-11 SE SE7409149A patent/SE419161B/xx unknown
- 1974-07-12 IT IT52093/74A patent/IT1016413B/it active
- 1974-07-12 JP JP8009474A patent/JPS5736893B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2236483B1 (enrdf_load_stackoverflow) | 1976-11-12 |
| DE2433285A1 (de) | 1975-01-30 |
| JPS5736893B2 (enrdf_load_stackoverflow) | 1982-08-06 |
| FR2236483A1 (enrdf_load_stackoverflow) | 1975-02-07 |
| SE7409149L (sv) | 1975-01-13 |
| SE419161B (sv) | 1981-07-20 |
| IT1016413B (it) | 1977-05-30 |
| DE2433285C2 (de) | 1985-02-07 |
| NL7409295A (nl) | 1975-01-14 |
| BE817401A (fr) | 1975-01-09 |
| CA1028622A (fr) | 1978-03-28 |
| ES428171A1 (es) | 1976-07-16 |
| JPS5036619A (enrdf_load_stackoverflow) | 1975-04-05 |
| AU7117574A (en) | 1976-01-15 |
| US3922338A (en) | 1975-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |