GB1453828A - Fluoro-substituted thiaxanthene derivatives - Google Patents
Fluoro-substituted thiaxanthene derivativesInfo
- Publication number
- GB1453828A GB1453828A GB5691072A GB5691072A GB1453828A GB 1453828 A GB1453828 A GB 1453828A GB 5691072 A GB5691072 A GB 5691072A GB 5691072 A GB5691072 A GB 5691072A GB 1453828 A GB1453828 A GB 1453828A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- nme
- reacting
- fluorothiaxanth
- ylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 6
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 2
- 101150065749 Churc1 gene Proteins 0.000 abstract 2
- 102100038239 Protein Churchill Human genes 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 2
- LFJMRGTVKNCAKR-UHFFFAOYSA-N 1-(3-chloropropyl)-4-(2-methoxyethyl)piperazine Chemical compound COCCN1CCN(CCCCl)CC1 LFJMRGTVKNCAKR-UHFFFAOYSA-N 0.000 abstract 1
- -1 2-dimethylsulphamoyl-6-fluorothiaxanth-9-ylidene Chemical group 0.000 abstract 1
- CIBQTAHLHLHRGX-UHFFFAOYSA-N 3-fluoro-9H-thioxanthene Chemical class FC=1C=CC=2CC3=CC=CC=C3SC=2C=1 CIBQTAHLHLHRGX-UHFFFAOYSA-N 0.000 abstract 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5691072A GB1453828A (en) | 1972-12-08 | 1972-12-08 | Fluoro-substituted thiaxanthene derivatives |
| CH1652873A CH590272A5 (enrdf_load_stackoverflow) | 1972-12-08 | 1973-11-23 | |
| NL7316035A NL7316035A (enrdf_load_stackoverflow) | 1972-12-08 | 1973-11-23 | |
| FI3618/73A FI57410C (fi) | 1972-12-08 | 1973-11-23 | Foerfarande foer framstaellning av nya neuroleptiskt aktiva 6-fluor-substituerade tiaxantenfoereningar och dessas salter |
| CH1585676A CH592085A5 (enrdf_load_stackoverflow) | 1972-12-08 | 1973-11-23 | |
| ZA738990A ZA738990B (en) | 1972-12-08 | 1973-11-26 | Heterocyclic organic compounds |
| AU62966/73A AU477427B2 (en) | 1972-12-08 | 1973-11-28 | 2-fluoro-substituted thiazanthene derivatives |
| DE2359359A DE2359359C3 (de) | 1972-12-08 | 1973-11-28 | Fluor-substituierte Thioxanthene, Verfahren zu ihrer Herstellung sowie diese enthaltende neuroleptische Mittel |
| AT1000373A AT332395B (de) | 1972-12-08 | 1973-11-29 | Verfahren zur herstellung von neuen fluor-substituierten thioxanthenen |
| IE2161/73A IE38554B1 (en) | 1972-12-08 | 1973-11-29 | Fluoro-substituted thiaxanthene derivatives |
| ES421098A ES421098A1 (es) | 1972-12-08 | 1973-12-03 | Un metodo para la preparacion de tiaxantenos fluor-susti- tuidos. |
| CS8429A CS176259B2 (enrdf_load_stackoverflow) | 1972-12-08 | 1973-12-06 | |
| JP48136256A JPS594436B2 (ja) | 1972-12-08 | 1973-12-07 | 複素環化合物の製法 |
| AR251406A AR202805A1 (es) | 1972-12-08 | 1973-12-07 | Metodo para la preparacion de tiaxantenos, fluor-substituidos |
| HUKE936A HU167778B (enrdf_load_stackoverflow) | 1972-12-08 | 1973-12-07 | |
| SE7316567A SE400287B (sv) | 1972-12-08 | 1973-12-07 | Forfarande for framstellning av fluorsubstituerade tiaxantenderivat |
| NO4693/73A NO138806C (no) | 1972-12-08 | 1973-12-07 | Analogifremgangsmaate for fremstilling av neuroleptisk aktive 6-fluor-substituert tiaxanten-derivater |
| CA187,713A CA1010870A (en) | 1972-12-08 | 1973-12-07 | Thiaxanthene derivative and method |
| PL1973178366A PL95266B1 (pl) | 1972-12-08 | 1973-12-07 | Sposob wytwarzania nowych pochodnych tiaksantenu |
| BE138618A BE808347A (fr) | 1972-12-08 | 1973-12-07 | Composes heterocycliques et methode de preparation de ceux-ci |
| FR7343766A FR2209573B1 (enrdf_load_stackoverflow) | 1972-12-08 | 1973-12-07 | |
| DK667273A DK145576C (da) | 1972-12-08 | 1973-12-10 | Analogifremgangsmaade til fremstilling af 6-fluor-substituerede thioxanthener eller syreadditionssalte deraf |
| AR256579A AR202672A1 (es) | 1972-12-08 | 1974-11-19 | Metodo para la preparacion de tiaxantenos fluorsustituidos |
| US05/593,559 US4044024A (en) | 1972-12-08 | 1975-07-07 | Thiaxanthene derivatives |
| US05/604,462 US4042695A (en) | 1972-12-08 | 1975-08-13 | Thiaxanthene derivatives, compositions thereof and methods of treating therewith |
| ES444294A ES444294A1 (es) | 1972-12-08 | 1976-01-14 | Un metodo para la preparacion de tiaxantenos fluor-substi- tuidos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5691072A GB1453828A (en) | 1972-12-08 | 1972-12-08 | Fluoro-substituted thiaxanthene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1453828A true GB1453828A (en) | 1976-10-27 |
Family
ID=10477876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5691072A Expired GB1453828A (en) | 1972-12-08 | 1972-12-08 | Fluoro-substituted thiaxanthene derivatives |
Country Status (19)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002902A1 (en) * | 1977-12-29 | 1979-07-11 | Kefalas A/S | Methylthiofluorothioxanthene derivative, its preparation and compositions containing it |
| US6127385A (en) * | 1999-03-04 | 2000-10-03 | Pharmaquest Limited | Method of treating depression using l-threo-methylphenidate |
| US6395752B1 (en) * | 1999-03-04 | 2002-05-28 | Pharmaquest Limited | Method of treating depression using 1-threo-methylphenidate |
| EP2301545A1 (en) * | 2007-01-05 | 2011-03-30 | BKG Pharma ApS | Thioxanthene derivatives for use in the treatment of infectious diseases |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5173489A (en) * | 1986-04-10 | 1992-12-22 | The Dupont Merck Pharmaceutical Co. | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers |
| GB8628903D0 (en) * | 1986-12-03 | 1987-01-07 | Lunbeck A S H | Neuroleptic compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE585338A (enrdf_load_stackoverflow) * | 1958-12-04 | |||
| FR1463787A (fr) * | 1963-10-14 | 1966-07-22 | Pfizer & Co C | Composés de phosphonium aminoalcoyl-trisubstitués, dérivés de tels composés, et procédés pour leur préparation |
-
1972
- 1972-12-08 GB GB5691072A patent/GB1453828A/en not_active Expired
-
1973
- 1973-11-23 CH CH1652873A patent/CH590272A5/xx not_active IP Right Cessation
- 1973-11-23 NL NL7316035A patent/NL7316035A/xx not_active Application Discontinuation
- 1973-11-23 CH CH1585676A patent/CH592085A5/xx not_active IP Right Cessation
- 1973-11-23 FI FI3618/73A patent/FI57410C/fi active
- 1973-11-26 ZA ZA738990A patent/ZA738990B/xx unknown
- 1973-11-28 DE DE2359359A patent/DE2359359C3/de not_active Expired
- 1973-11-29 AT AT1000373A patent/AT332395B/de not_active IP Right Cessation
- 1973-11-29 IE IE2161/73A patent/IE38554B1/xx unknown
- 1973-12-03 ES ES421098A patent/ES421098A1/es not_active Expired
- 1973-12-06 CS CS8429A patent/CS176259B2/cs unknown
- 1973-12-07 AR AR251406A patent/AR202805A1/es active
- 1973-12-07 FR FR7343766A patent/FR2209573B1/fr not_active Expired
- 1973-12-07 SE SE7316567A patent/SE400287B/xx unknown
- 1973-12-07 JP JP48136256A patent/JPS594436B2/ja not_active Expired
- 1973-12-07 BE BE138618A patent/BE808347A/xx not_active IP Right Cessation
- 1973-12-07 NO NO4693/73A patent/NO138806C/no unknown
- 1973-12-07 HU HUKE936A patent/HU167778B/hu unknown
- 1973-12-07 PL PL1973178366A patent/PL95266B1/pl unknown
- 1973-12-10 DK DK667273A patent/DK145576C/da active
-
1974
- 1974-11-19 AR AR256579A patent/AR202672A1/es active
-
1976
- 1976-01-14 ES ES444294A patent/ES444294A1/es not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002902A1 (en) * | 1977-12-29 | 1979-07-11 | Kefalas A/S | Methylthiofluorothioxanthene derivative, its preparation and compositions containing it |
| US4235916A (en) * | 1977-12-29 | 1980-11-25 | Kefalas A/S | 2-Methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and salts thereof, neuroleptic compositions and method of use |
| US6127385A (en) * | 1999-03-04 | 2000-10-03 | Pharmaquest Limited | Method of treating depression using l-threo-methylphenidate |
| US6395752B1 (en) * | 1999-03-04 | 2002-05-28 | Pharmaquest Limited | Method of treating depression using 1-threo-methylphenidate |
| EP2301545A1 (en) * | 2007-01-05 | 2011-03-30 | BKG Pharma ApS | Thioxanthene derivatives for use in the treatment of infectious diseases |
| AU2008203743B2 (en) * | 2007-01-05 | 2012-07-12 | Bkg Pharma Aps | Thioxanthene derivates useful to treat infectious diseases |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |