GB1449708A - N4-acylarabinonucleosides and the preparation thereof - Google Patents

N4-acylarabinonucleosides and the preparation thereof

Info

Publication number
GB1449708A
GB1449708A GB2367374A GB2367374A GB1449708A GB 1449708 A GB1449708 A GB 1449708A GB 2367374 A GB2367374 A GB 2367374A GB 2367374 A GB2367374 A GB 2367374A GB 1449708 A GB1449708 A GB 1449708A
Authority
GB
United Kingdom
Prior art keywords
acid anhydride
acyl
compounds
water
acylarabinonucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2367374A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of GB1449708A publication Critical patent/GB1449708A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
GB2367374A 1973-05-30 1974-05-28 N4-acylarabinonucleosides and the preparation thereof Expired GB1449708A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5970973A JPS535678B2 (zh) 1973-05-30 1973-05-30

Publications (1)

Publication Number Publication Date
GB1449708A true GB1449708A (en) 1976-09-15

Family

ID=13120999

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2367374A Expired GB1449708A (en) 1973-05-30 1974-05-28 N4-acylarabinonucleosides and the preparation thereof

Country Status (6)

Country Link
JP (1) JPS535678B2 (zh)
CH (1) CH582695A5 (zh)
DE (1) DE2426304A1 (zh)
FR (1) FR2231388B1 (zh)
GB (1) GB1449708A (zh)
HU (1) HU170244B (zh)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
US8716262B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8759510B2 (en) 2008-06-11 2014-06-24 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8859756B2 (en) 2010-03-31 2014-10-14 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
CN108409819A (zh) * 2018-04-25 2018-08-17 山东大学 一种新型阿糖胞苷前药DA-Ara纳米组装体的制备方法及应用
CN108610384A (zh) * 2018-05-31 2018-10-02 沈阳药科大学 基于肠道mct1载体蛋白设计的前药及其制备方法
CN108727449A (zh) * 2018-04-25 2018-11-02 山东大学 一种新型阿糖胞苷前药MA-Ara纳米组装体的制备方法及应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2614946A1 (de) * 1975-04-08 1976-10-14 Asahi Chemical Ind Neue nucleotidderivate
JPS51143683A (en) * 1975-06-06 1976-12-10 Yamasa Shoyu Co Ltd A process for preparing n4- acylarabinofuranosyl cytosines
JPS5840528B2 (ja) * 1975-12-31 1983-09-06 旭化成株式会社 Ｎ４− ベヘノイルシトシンアラビノシドノスイヨウカホウホウ
JPS552602A (en) * 1978-06-20 1980-01-10 Yamasa Shoyu Co Ltd 1-beta-d-arabinofranosylcytosine-5'-phosphoric acid oleyl ester
JPS5622724A (en) * 1979-08-02 1981-03-03 Asahi Chem Ind Co Ltd Pharmaceutical preparation of n4-acylcytosine arabinoside
DE3323621A1 (de) * 1982-07-08 1984-03-01 Yamasa Shoyu K.K., Choshi, Chiba Pharmazeutisches praeparat mit die antitumor-wirkung verstaerkender wirkung, ein solches praeparat enthaltende chemotherapeutische zusammensetzung und verwendung des praeparates zur unterstuetzung der antitumor-behandlung beim menschen und tier
JPS5925327A (ja) * 1982-07-31 1984-02-09 Hidematsu Hirai 抗腫瘍性複合体の製造方法
JPS6330879Y2 (zh) * 1985-08-30 1988-08-17
EP3453386A1 (en) * 2017-09-08 2019-03-13 Universite D'angers Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759510B2 (en) 2008-06-11 2014-06-24 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
US8716262B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8957045B2 (en) 2008-12-23 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidates
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8859756B2 (en) 2010-03-31 2014-10-14 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
CN108409819A (zh) * 2018-04-25 2018-08-17 山东大学 一种新型阿糖胞苷前药DA-Ara纳米组装体的制备方法及应用
CN108727449A (zh) * 2018-04-25 2018-11-02 山东大学 一种新型阿糖胞苷前药MA-Ara纳米组装体的制备方法及应用
CN108610384A (zh) * 2018-05-31 2018-10-02 沈阳药科大学 基于肠道mct1载体蛋白设计的前药及其制备方法
CN108610384B (zh) * 2018-05-31 2022-02-22 沈阳药科大学 基于肠道mct1载体蛋白设计的前药及其制备方法

Also Published As

Publication number Publication date
FR2231388B1 (zh) 1977-11-04
HU170244B (zh) 1977-05-28
JPS5018482A (zh) 1975-02-26
CH582695A5 (zh) 1976-12-15
JPS535678B2 (zh) 1978-03-01
FR2231388A1 (zh) 1974-12-27
DE2426304C2 (zh) 1988-03-17
DE2426304A1 (de) 1975-01-02

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930528