JPS5018482A - - Google Patents

Info

Publication number
JPS5018482A
JPS5018482A JP48059709A JP5970973A JPS5018482A JP S5018482 A JPS5018482 A JP S5018482A JP 48059709 A JP48059709 A JP 48059709A JP 5970973 A JP5970973 A JP 5970973A JP S5018482 A JPS5018482 A JP S5018482A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP48059709A
Other languages
Japanese (ja)
Other versions
JPS535678B2 (zh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to JP5970973A priority Critical patent/JPS535678B2/ja
Priority to GB2367374A priority patent/GB1449708A/en
Priority to DE19742426304 priority patent/DE2426304A1/de
Priority to HUAA772A priority patent/HU170244B/hu
Priority to FR7418862A priority patent/FR2231388B1/fr
Priority to CH738274A priority patent/CH582695A5/xx
Publication of JPS5018482A publication Critical patent/JPS5018482A/ja
Publication of JPS535678B2 publication Critical patent/JPS535678B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP5970973A 1973-05-30 1973-05-30 Expired JPS535678B2 (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP5970973A JPS535678B2 (zh) 1973-05-30 1973-05-30
GB2367374A GB1449708A (en) 1973-05-30 1974-05-28 N4-acylarabinonucleosides and the preparation thereof
DE19742426304 DE2426304A1 (de) 1973-05-30 1974-05-29 N-acyl-l-beta-d-arabinofuranosylcytosin-derivate, verfahren zu ihrer herstellung und arzneimittel
HUAA772A HU170244B (zh) 1973-05-30 1974-05-29
FR7418862A FR2231388B1 (zh) 1973-05-30 1974-05-30
CH738274A CH582695A5 (zh) 1973-05-30 1974-05-30

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5970973A JPS535678B2 (zh) 1973-05-30 1973-05-30

Publications (2)

Publication Number Publication Date
JPS5018482A true JPS5018482A (zh) 1975-02-26
JPS535678B2 JPS535678B2 (zh) 1978-03-01

Family

ID=13120999

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5970973A Expired JPS535678B2 (zh) 1973-05-30 1973-05-30

Country Status (6)

Country Link
JP (1) JPS535678B2 (zh)
CH (1) CH582695A5 (zh)
DE (1) DE2426304A1 (zh)
FR (1) FR2231388B1 (zh)
GB (1) GB1449708A (zh)
HU (1) HU170244B (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51143683A (en) * 1975-06-06 1976-12-10 Yamasa Shoyu Co Ltd A process for preparing n4- acylarabinofuranosyl cytosines
JPS5283910A (en) * 1975-12-31 1977-07-13 Asahi Chem Ind Co Ltd Solubilization of n4-behenoycytosine -behenoycytosine arabinoside
JPS5925327A (ja) * 1982-07-31 1984-02-09 Hidematsu Hirai 抗腫瘍性複合体の製造方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2614946A1 (de) * 1975-04-08 1976-10-14 Asahi Chemical Ind Neue nucleotidderivate
JPS552602A (en) * 1978-06-20 1980-01-10 Yamasa Shoyu Co Ltd 1-beta-d-arabinofranosylcytosine-5'-phosphoric acid oleyl ester
JPS5622724A (en) * 1979-08-02 1981-03-03 Asahi Chem Ind Co Ltd Pharmaceutical preparation of n4-acylcytosine arabinoside
DE3323621A1 (de) * 1982-07-08 1984-03-01 Yamasa Shoyu K.K., Choshi, Chiba Pharmazeutisches praeparat mit die antitumor-wirkung verstaerkender wirkung, ein solches praeparat enthaltende chemotherapeutische zusammensetzung und verwendung des praeparates zur unterstuetzung der antitumor-behandlung beim menschen und tier
JPS6330879Y2 (zh) * 1985-08-30 1988-08-17
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
CN102325783A (zh) 2008-12-23 2012-01-18 法莫赛特股份有限公司 嘌呤核苷的合成
WO2010075549A2 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside phosphoramidates
SI3290428T1 (sl) 2010-03-31 2022-01-31 Gilead Pharmasset Llc Tableta, ki obsega kristalinični (S)-izopropil 2-(((S)-(((2R,3R,4R,5R) -5-(2,4-diokso-3,4-dihidropirimidin-1(2H)-il)-4-fluoro-3-hidroksi-4- metiltetrahidrofuran-2-il)metoksi)(fenoksi)fosforil)amino)propanoat
EP3453386A1 (en) * 2017-09-08 2019-03-13 Universite D'angers Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof
CN108409819A (zh) * 2018-04-25 2018-08-17 山东大学 一种新型阿糖胞苷前药DA-Ara纳米组装体的制备方法及应用
CN108727449A (zh) * 2018-04-25 2018-11-02 山东大学 一种新型阿糖胞苷前药MA-Ara纳米组装体的制备方法及应用
CN108610384B (zh) * 2018-05-31 2022-02-22 沈阳药科大学 基于肠道mct1载体蛋白设计的前药及其制备方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51143683A (en) * 1975-06-06 1976-12-10 Yamasa Shoyu Co Ltd A process for preparing n4- acylarabinofuranosyl cytosines
JPS5341157B2 (zh) * 1975-06-06 1978-10-31
JPS5283910A (en) * 1975-12-31 1977-07-13 Asahi Chem Ind Co Ltd Solubilization of n4-behenoycytosine -behenoycytosine arabinoside
JPS5840528B2 (ja) * 1975-12-31 1983-09-06 旭化成株式会社 Ｎ４− ベヘノイルシトシンアラビノシドノスイヨウカホウホウ
JPS5925327A (ja) * 1982-07-31 1984-02-09 Hidematsu Hirai 抗腫瘍性複合体の製造方法
JPH0449524B2 (zh) * 1982-07-31 1992-08-11 Hidematsu Hirai

Also Published As

Publication number Publication date
FR2231388B1 (zh) 1977-11-04
HU170244B (zh) 1977-05-28
GB1449708A (en) 1976-09-15
CH582695A5 (zh) 1976-12-15
JPS535678B2 (zh) 1978-03-01
FR2231388A1 (zh) 1974-12-27
DE2426304C2 (zh) 1988-03-17
DE2426304A1 (de) 1975-01-02

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