GB1391838A - Rearrangement of 6-acylamidopenicillanic acid sulphoxides and production of cephalexin or hetacephalexin - Google Patents

Rearrangement of 6-acylamidopenicillanic acid sulphoxides and production of cephalexin or hetacephalexin

Info

Publication number
GB1391838A
GB1391838A GB2216472A GB2216472A GB1391838A GB 1391838 A GB1391838 A GB 1391838A GB 2216472 A GB2216472 A GB 2216472A GB 2216472 A GB2216472 A GB 2216472A GB 1391838 A GB1391838 A GB 1391838A
Authority
GB
United Kingdom
Prior art keywords
acid
hetacephalexin
cephalexin
alkyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2216472A
Other languages
English (en)
Inventor
J Rubinfeld
R Lemiuex
R Raap
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB1391838A publication Critical patent/GB1391838A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/08—Preparation by forming the ring or condensed ring systems
    • C07D501/10—Preparation by forming the ring or condensed ring systems from compounds containing the penicillin ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
GB2216472A 1971-05-11 1972-05-11 Rearrangement of 6-acylamidopenicillanic acid sulphoxides and production of cephalexin or hetacephalexin Expired GB1391838A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00143683A US3843637A (en) 1971-05-11 1971-05-11 Process for rearranging 6-acylamidopenicillanic acid-1-oxides to 7-acyla mido-3-methyl-ceph-3-em-4-carboxylic acids

Publications (1)

Publication Number Publication Date
GB1391838A true GB1391838A (en) 1975-04-23

Family

ID=22505135

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2216472A Expired GB1391838A (en) 1971-05-11 1972-05-11 Rearrangement of 6-acylamidopenicillanic acid sulphoxides and production of cephalexin or hetacephalexin

Country Status (27)

Country Link
US (1) US3843637A (no)
JP (3) JPS565229B1 (no)
AR (3) AR194364A1 (no)
AT (1) AT325201B (no)
AU (1) AU461358B2 (no)
BE (1) BE783222A (no)
CA (1) CA986096A (no)
CH (1) CH578007A5 (no)
CS (3) CS190399B2 (no)
DD (1) DD99584A5 (no)
DE (1) DE2222953A1 (no)
DK (1) DK140845B (no)
ES (3) ES402672A1 (no)
FI (1) FI58925C (no)
FR (1) FR2143667B1 (no)
GB (1) GB1391838A (no)
HU (2) HU166186B (no)
IE (1) IE36353B1 (no)
IL (1) IL39382A (no)
NL (1) NL7206193A (no)
NO (3) NO146202C (no)
PH (1) PH13518A (no)
PL (3) PL94780B1 (no)
SE (3) SE411045B (no)
SU (2) SU626704A3 (no)
YU (3) YU122672A (no)
ZA (1) ZA723119B (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182709A (en) * 1976-01-15 1980-01-08 Glaxo Group Limited Manufacture of semi-synthetic penicillin antibiotics

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2143211B1 (no) * 1971-06-24 1975-10-31 Fujisawa Pharmaceutical Co
JPS536158B2 (no) * 1972-03-23 1978-03-04
US3960851A (en) * 1972-05-15 1976-06-01 Eli Lilly And Company Preparation of desacetoxy-cephalosporin sulfoxides from penicillin sulfoxides
GB1441587A (en) * 1972-07-14 1976-07-07 Glaxo Lab Ltd Cephalosporin compounds
GB1442785A (en) * 1972-12-09 1976-07-14 Nikken Chemicals Co Ltd Desacetoxy ceaphalosporanic acids
GB1465893A (en) * 1973-02-09 1977-03-02 Gist Brocades Nv I-carboxypropenyl-4-iminothio-azetidine-2-one derivatives methods for their preparation and use
US4010156A (en) * 1973-04-19 1977-03-01 American Home Products Corporation Process for the rearrangement of penicillins to cephalosporins and intermediate compounds thereof
JPS5084591A (no) * 1973-11-29 1975-07-08
US3953440A (en) * 1974-12-13 1976-04-27 Eli Lilly And Company Deacetoxycephalosporins via penicillin sulfoxide rearrangement
US4061862A (en) * 1975-10-06 1977-12-06 Bristol-Myers Company Derivatives of 7-(cyclized)phenylglycyl-3-triazolo-thio methyl cephalosporin
US4091213A (en) * 1975-12-12 1978-05-23 Bristol-Myers Company 7-Cyclizedamino-3-heterothiomethyl cephalosporin derivatives
NO2451643T3 (no) 2009-07-08 2018-01-20

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH565809A5 (no) * 1969-03-11 1975-08-29 Glaxo Lab Ltd

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182709A (en) * 1976-01-15 1980-01-08 Glaxo Group Limited Manufacture of semi-synthetic penicillin antibiotics

Also Published As

Publication number Publication date
CS190400B2 (en) 1979-05-31
YU174979A (en) 1983-01-21
FR2143667B1 (no) 1977-01-28
SE414177B (sv) 1980-07-14
SE414176B (sv) 1980-07-14
NO146241B (no) 1982-05-18
AR200720A1 (es) 1974-12-13
AR194364A1 (es) 1973-07-13
BE783222A (fr) 1972-11-09
ZA723119B (en) 1973-05-30
YU174879A (en) 1983-02-28
CS190399B2 (en) 1979-05-31
NO146203B (no) 1982-05-10
FI58925C (fi) 1981-05-11
PH13518A (en) 1980-06-03
NO146241C (no) 1982-08-25
FR2143667A1 (no) 1973-02-09
AR197310A1 (es) 1974-03-29
NL7206193A (no) 1972-11-14
JPS565758B2 (no) 1981-02-06
PL85195B1 (no) 1976-04-30
YU122672A (en) 1982-02-28
PL94780B1 (pl) 1977-08-31
CA986096A (en) 1976-03-23
IL39382A0 (en) 1972-07-26
JPS565759B2 (no) 1981-02-06
AT325201B (de) 1975-10-10
DK140845B (da) 1979-11-26
NO146203C (no) 1982-08-18
CS190367B2 (en) 1979-05-31
DD99584A5 (no) 1973-08-12
NO146202C (no) 1982-08-18
FI58925B (fi) 1981-01-30
SU626704A3 (ru) 1978-09-30
SE7414727L (no) 1974-11-22
HU166186B (no) 1975-02-28
HU165177B (no) 1974-07-27
ES402672A1 (es) 1975-10-16
JPS55108875A (en) 1980-08-21
CH578007A5 (no) 1976-07-30
AU4187672A (en) 1973-11-08
PL94030B1 (no) 1977-07-30
ES430117A1 (es) 1976-10-16
DE2222953A1 (de) 1973-03-01
AU461358B2 (en) 1975-05-22
ES430116A1 (es) 1976-10-16
SU662013A3 (ru) 1979-05-05
SE411045B (sv) 1979-11-26
IE36353L (en) 1972-11-11
US3843637A (en) 1974-10-22
SE7414728L (no) 1974-11-22
JPS565229B1 (no) 1981-02-04
DK140845C (no) 1980-05-12
NO146202B (no) 1982-05-10
IE36353B1 (en) 1976-10-13
IL39382A (en) 1975-07-28
JPS55108876A (en) 1980-08-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee