GB1389194A - Antibiotics - Google Patents

Antibiotics

Info

Publication number
GB1389194A
GB1389194A GB353171A GB353171A GB1389194A GB 1389194 A GB1389194 A GB 1389194A GB 353171 A GB353171 A GB 353171A GB 353171 A GB353171 A GB 353171A GB 1389194 A GB1389194 A GB 1389194A
Authority
GB
United Kingdom
Prior art keywords
denotes
compounds
syn
isomer
rdurule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB353171A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB353171A priority Critical patent/GB1389194A/en
Priority to DE2264676*A priority patent/DE2264676A1/de
Priority to BE778630A priority patent/BE778630A/xx
Priority to AU38450/72A priority patent/AU474062B2/en
Priority to IE117/72A priority patent/IE36041B1/xx
Priority to ZA720568A priority patent/ZA72568B/xx
Priority to CH124072A priority patent/CH598261A5/xx
Priority to ES399267A priority patent/ES399267A1/es
Priority to BE778631A priority patent/BE778631A/xx
Priority to NL7201157A priority patent/NL7201157A/xx
Priority to NL7201156A priority patent/NL7201156A/xx
Priority to DE19722204060 priority patent/DE2204060A1/de
Priority to CA133,364A priority patent/CA1022924A/en
Priority to IL7238657A priority patent/IL38657A/xx
Priority to PL15316172A priority patent/PL102925B1/pl
Priority to DK38172A priority patent/DK143853C/da
Priority to DE19722204108 priority patent/DE2204108A1/de
Priority to AT70172A priority patent/AT326814B/de
Priority to AT70272*#A priority patent/AT327375B/de
Priority to JP7210416A priority patent/JPS5248996B1/ja
Priority to FR7203092A priority patent/FR2123544B1/fr
Priority to FR7203093A priority patent/FR2123545A1/fr
Priority claimed from KR7200155A external-priority patent/KR790000084B1/ko
Priority to KR7200155A priority patent/KR790000084B1/ko
Priority to US466780A priority patent/US3926957A/en
Priority to ES427859A priority patent/ES427859A1/es
Priority to AT671474A priority patent/AT345452B/de
Priority to SE7415536A priority patent/SE7415536L/xx
Priority to US05/554,014 priority patent/US4024134A/en
Publication of GB1389194A publication Critical patent/GB1389194A/en
Priority to CH774277A priority patent/CH621790A5/de
Priority to US05/951,761 priority patent/US4209616A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB353171A 1971-01-29 1971-01-29 Antibiotics Expired GB1389194A (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
GB353171A GB1389194A (en) 1971-01-29 1971-01-29 Antibiotics
DE19722204108 DE2204108A1 (de) 1971-01-29 1972-01-28 Cephalosporin- und Penicillin-Antibiotika
DK38172A DK143853C (da) 1971-01-29 1972-01-28 Analogifremgangsmaade til fremstilling af cephalosporinforbindelser eller utoxiske salte eller hydrater deraf
AU38450/72A AU474062B2 (en) 1971-01-29 1972-01-28 &- hydroxyiminoacylamido and & - acyloxyiminoacylamido penicillin and cephalosporin antibiotics
IE117/72A IE36041B1 (en) 1971-01-29 1972-01-28 Improvements in or relating to antibiotics
ZA720568A ZA72568B (en) 1971-01-29 1972-01-28 Improvements in or relating to antibiotics
CH124072A CH598261A5 (enrdf_load_stackoverflow) 1971-01-29 1972-01-28
ES399267A ES399267A1 (es) 1971-01-29 1972-01-28 Un procedimiento para la preparacion de cefalosporinas.
BE778631A BE778631A (enrdf_load_stackoverflow) 1971-01-29 1972-01-28
AT70172A AT326814B (de) 1971-01-29 1972-01-28 Verfahren zur herstellung von neuen cephalosporinen und penicillinen
NL7201156A NL7201156A (enrdf_load_stackoverflow) 1971-01-29 1972-01-28
DE19722204060 DE2204060A1 (de) 1971-01-29 1972-01-28 Cephalosporin- und Penicillin-Antibiotika
CA133,364A CA1022924A (en) 1971-01-29 1972-01-28 Preparation of syn alpha-hydroxylminoacylamido and alpha-acyloxylminoacylamido penicillins and cephalosporins
IL7238657A IL38657A (en) 1971-01-29 1972-01-28 Hydroxyimino-and -acyloxyimino-acylamido cephalosporins
PL15316172A PL102925B1 (pl) 1971-01-29 1972-01-28 Sposob wytwarzania nowych pochodnych cefalosporyny
DE2264676*A DE2264676A1 (de) 1971-01-29 1972-01-28 Penicillin-antibiotika
AT70272*#A AT327375B (de) 1971-01-29 1972-01-28 Verfahren zur herstellung von neuen cephalosporinen und penicillinen
NL7201157A NL7201157A (enrdf_load_stackoverflow) 1971-01-29 1972-01-28
BE778630A BE778630A (enrdf_load_stackoverflow) 1971-01-29 1972-01-28
JP7210416A JPS5248996B1 (enrdf_load_stackoverflow) 1971-01-29 1972-01-28
FR7203093A FR2123545A1 (en) 1971-01-29 1972-01-31 (2-hydroxy (or alkoxy)imino)acylamido penicillanic and - cephalosporanic acids - useful as antibiotics and intermediates
FR7203092A FR2123544B1 (enrdf_load_stackoverflow) 1971-01-29 1972-01-31
KR7200155A KR790000084B1 (en) 1971-01-29 1972-02-03 Process for preparation of antibiotics of cephalosphorin and penicillin series
US466780A US3926957A (en) 1971-01-29 1974-05-03 Penicillin antibiotics
ES427859A ES427859A1 (es) 1971-01-29 1974-07-01 Un procedimiento para la preparacion de compuestos de cefa-losporina.
AT671474A AT345452B (de) 1971-01-29 1974-08-16 Verfahren zur herstellung von neuen cephalosporinen
SE7415536A SE7415536L (enrdf_load_stackoverflow) 1971-01-29 1974-12-11
US05/554,014 US4024134A (en) 1971-01-29 1975-02-28 Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
CH774277A CH621790A5 (en) 1971-01-29 1977-06-24 Process for the preparation of a syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7beta-acylamidocephem-4-carboxylic acids
US05/951,761 US4209616A (en) 1971-01-29 1978-10-16 Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB353171A GB1389194A (en) 1971-01-29 1971-01-29 Antibiotics
GB4588571 1971-10-01
KR7200155A KR790000084B1 (en) 1971-01-29 1972-02-03 Process for preparation of antibiotics of cephalosphorin and penicillin series

Publications (1)

Publication Number Publication Date
GB1389194A true GB1389194A (en) 1975-04-03

Family

ID=27254286

Family Applications (1)

Application Number Title Priority Date Filing Date
GB353171A Expired GB1389194A (en) 1971-01-29 1971-01-29 Antibiotics

Country Status (9)

Country Link
AT (2) AT326814B (enrdf_load_stackoverflow)
AU (1) AU474062B2 (enrdf_load_stackoverflow)
BE (2) BE778630A (enrdf_load_stackoverflow)
CH (2) CH598261A5 (enrdf_load_stackoverflow)
DE (3) DE2204108A1 (enrdf_load_stackoverflow)
ES (2) ES399267A1 (enrdf_load_stackoverflow)
FR (1) FR2123544B1 (enrdf_load_stackoverflow)
GB (1) GB1389194A (enrdf_load_stackoverflow)
NL (2) NL7201156A (enrdf_load_stackoverflow)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409214A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4409215A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
US4503234A (en) * 1980-07-24 1985-03-05 Lonza Ltd. Production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acetic esters

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033950A (en) * 1971-05-14 1977-07-05 Glaxo Laboratories Limited 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US4064346A (en) * 1971-05-14 1977-12-20 Glaxo Laboratories Limited 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
GB1443950A (en) * 1972-10-25 1976-07-28 Glaxo Lab Ltd Acylamido-penam-carboxylic acids and their derivatives
US4079178A (en) * 1971-05-14 1978-03-14 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position
GB1447114A (en) * 1973-02-20 1976-08-25 Glaxo Lab Ltd Process for the preparation of 2-aryl-2-hydroxyiminoacetic acid
GB1472534A (en) * 1973-07-06 1977-05-04 Glaxo Lab Ltd 7beta-hydroxyiminoacylamido-cephalosporins
US4095021A (en) 1973-12-21 1978-06-13 Glaxo Laboratories Limited 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof
US4144392A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile
US4020058A (en) * 1974-10-03 1977-04-26 Glaxo Laboratories Limited Improvements in or relating to cephalosporin antibiotics
US4200746A (en) 1974-12-20 1980-04-29 Glaxo Laboratories, Ltd. Cephalosporins
SE432254B (sv) * 1975-02-04 1984-03-26 Fujisawa Pharmaceutical Co Analogiforfarande for framstellning av 3-substituerade 7-(alfa,alfa-disubstituerade acetamido)-3-cefem-4-karboxylsyror
GB1555471A (en) * 1975-06-19 1979-11-14 Glaxo Lab Ltd 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof
US4165430A (en) 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
FR2384779A1 (fr) * 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-chloro ou 3-methoxy 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2716677C2 (de) 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
FR2418233A2 (fr) * 1978-02-22 1979-09-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkylthio ou 3-acylamino 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
GB2173791B (en) * 1985-04-16 1989-07-05 Ici Plc Fungicidal cyano oximes
GB8927871D0 (en) * 1989-12-08 1990-02-14 Beecham Group Plc Novel compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1159449B (de) * 1961-03-22 1963-12-19 Gruenenthal Chemie Verfahren zur Herstellung von 6-Acylaminopenicillansaeuren und deren Salzen
SE311519B (enrdf_load_stackoverflow) * 1962-12-14 1969-06-16 Astra Ab
GB1208014A (en) * 1967-03-23 1970-10-07 Glaxo Lab Ltd Cephalosporins
GB1208015A (en) * 1967-03-23 1970-10-07 Glaxo Lab Ltd Cephalosporins

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409214A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4409215A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
US4423213A (en) 1979-11-19 1983-12-27 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4462999A (en) * 1979-11-19 1984-07-31 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
US4585860A (en) * 1979-11-19 1986-04-29 Fujisawa Pharmaceutical Co., Ltd. 7-acylamino-3-vinylcephalosporanic acid derivatives useful for treatment of infectious diseases in human beings and animals
US5594132A (en) * 1979-11-19 1997-01-14 Fujisawa Pharmaceutical Co., Ltd. 7-acylamino-3-substituted cephalosporanic acid derivatives
US4503234A (en) * 1980-07-24 1985-03-05 Lonza Ltd. Production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acetic esters
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives

Also Published As

Publication number Publication date
ES427859A1 (es) 1976-08-01
DE2204108A1 (de) 1972-08-24
AT327375B (de) 1976-01-26
FR2123544B1 (enrdf_load_stackoverflow) 1975-10-10
FR2123544A1 (enrdf_load_stackoverflow) 1972-09-08
AT326814B (de) 1975-12-29
AU474062B2 (en) 1976-07-15
ES399267A1 (es) 1975-06-16
CH598261A5 (enrdf_load_stackoverflow) 1978-04-28
ATA70272A (de) 1975-04-15
NL7201157A (enrdf_load_stackoverflow) 1972-08-01
DE2264676A1 (de) 1974-08-08
NL7201156A (enrdf_load_stackoverflow) 1972-08-01
AU3845072A (en) 1973-08-02
DE2204060A1 (de) 1972-08-10
CH621790A5 (en) 1981-02-27
ATA70172A (de) 1975-03-15
BE778631A (enrdf_load_stackoverflow) 1972-07-28
BE778630A (enrdf_load_stackoverflow) 1972-07-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee